Phosphoinositide-mediated oligomerization of a defensin induces cell lysis
Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells. Many CAPs act at the plasma membrane of cells leading to membrane destabilization and permeabilization. In...
Main Authors: | Ivan KH Poon, Amy A Baxter, Fung T Lay, Grant D Mills, Christopher G Adda, Jennifer AE Payne, Thanh Kha Phan, Gemma F Ryan, Julie A White, Prem K Veneer, Nicole L van der Weerden, Marilyn A Anderson, Marc Kvansakul, Mark D Hulett |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-04-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/01808 |
Similar Items
-
Regulation of phosphoinositide metabolism in Apicomplexan parasites
by: Angela Arabiotorre, et al.
Published: (2023-09-01) -
Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption
by: Scott A. Williams, et al.
Published: (2023-03-01) -
Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration
by: Guneet K. Bindra, et al.
Published: (2022-02-01) -
Phospholipids/
by: Hawthorne, J. N., et al.
Published: (1982) -
Bacterial flagellar capping proteins adopt diverse oligomeric states
by: Sandra Postel, et al.
Published: (2016-09-01)