Brain gamma rhythm and potential treatment of neurodegenerative disease
In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz), and their induction and modulation by physic...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Journal of Neurorestoratology |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/JNR.2020.9040002 |
| _version_ | 1797710181127159808 |
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| author | Jianhua Zhao Ailin Du Chengbiao Lu |
| author_facet | Jianhua Zhao Ailin Du Chengbiao Lu |
| author_sort | Jianhua Zhao |
| collection | DOAJ |
| description | In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz), and their induction and modulation by physical stimulation, such as light and sound, and pharmacological stimulation with agents such as agonists of the kainite subunit ionotropic glutamate receptor, metabotropic glutamate receptor, metabotropic cholinergic receptor, and nicotinic cholinergic receptor. Recent findings demonstrate that boosting gamma oscillations in specific brain areas appears to be able to restore cognitive function and reduce relative pathology in neurodegenerative diseases, such as Alzheimer’s disease. Thus, exploration of strategies to enhance or restore impaired gamma oscillations may be a new and effective method to improve the conditions in these devastating diseases. |
| first_indexed | 2024-03-12T06:48:29Z |
| format | Article |
| id | doaj.art-9f578906953b4acab4dbf91a8e7b57fb |
| institution | Directory Open Access Journal |
| issn | 2324-2426 |
| language | English |
| last_indexed | 2024-03-12T06:48:29Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Neurorestoratology |
| spelling | doaj.art-9f578906953b4acab4dbf91a8e7b57fb2023-09-03T00:27:30ZengElsevierJournal of Neurorestoratology2324-24262020-03-0181263110.26599/JNR.2020.9040002Brain gamma rhythm and potential treatment of neurodegenerative diseaseJianhua Zhao0Ailin Du1Chengbiao Lu2<institution content-type="dept">Department of Neurology</institution>, <institution>First Affiliated Hospital of Xinxiang Medical University</institution>, <city>Weihui</city> <postal-code>453100</postal-code>, <state>Henan</state>, <country>China</country>;<institution content-type="dept">Henan International Joint Laboratory for Non-invasive Brain Modulation / Key Laboratory for Brain Research of Henan Province</institution>, <institution>Xinxiang Medical University</institution>, <city>Xinxiang</city> <postal-code>453003</postal-code>, <state>Henan</state>, <country>China</country>;<institution>Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia / Henan Key Laboratory of Neurorestoratology</institution>, <city>Weihui</city> <postal-code>453100</postal-code>, <state>Henan</state>, <country>China</country>;In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz), and their induction and modulation by physical stimulation, such as light and sound, and pharmacological stimulation with agents such as agonists of the kainite subunit ionotropic glutamate receptor, metabotropic glutamate receptor, metabotropic cholinergic receptor, and nicotinic cholinergic receptor. Recent findings demonstrate that boosting gamma oscillations in specific brain areas appears to be able to restore cognitive function and reduce relative pathology in neurodegenerative diseases, such as Alzheimer’s disease. Thus, exploration of strategies to enhance or restore impaired gamma oscillations may be a new and effective method to improve the conditions in these devastating diseases.https://www.sciopen.com/article/10.26599/JNR.2020.9040002brain network oscillationgamma oscillationcognitive functionneurodegenerative disease |
| spellingShingle | Jianhua Zhao Ailin Du Chengbiao Lu Brain gamma rhythm and potential treatment of neurodegenerative disease Journal of Neurorestoratology brain network oscillation gamma oscillation cognitive function neurodegenerative disease |
| title | Brain gamma rhythm and potential treatment of neurodegenerative disease |
| title_full | Brain gamma rhythm and potential treatment of neurodegenerative disease |
| title_fullStr | Brain gamma rhythm and potential treatment of neurodegenerative disease |
| title_full_unstemmed | Brain gamma rhythm and potential treatment of neurodegenerative disease |
| title_short | Brain gamma rhythm and potential treatment of neurodegenerative disease |
| title_sort | brain gamma rhythm and potential treatment of neurodegenerative disease |
| topic | brain network oscillation gamma oscillation cognitive function neurodegenerative disease |
| url | https://www.sciopen.com/article/10.26599/JNR.2020.9040002 |
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