Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study
Introduction: Periodontal diseases are inflammatory in nature involving interplay between the bacterial plaque and the microorganisms, with the response of the host playing a pivotal role in either attenuating or eliminating the disease. Rheumatoid Arthritis (RA) is also a chronic inflammatory di...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9792/24412_CE(RA1)_F(T)_PF1(RB_SS)_PFA(RB_SS).pdf |
| Summary: | Introduction: Periodontal diseases are inflammatory in nature
involving interplay between the bacterial plaque and the microorganisms, with the response of the host playing a pivotal role
in either attenuating or eliminating the disease. Rheumatoid
Arthritis (RA) is also a chronic inflammatory disease which
shares common risk factors with periodontitis. Porphyromonas
Gingivalis and Pentraxin 3 (an acute inflammatory protein) have
been observed to be associated with both the diseases.
Aim: This study was done to determine if there was any association between Pophyromonas Gingivalis and Pentraxin 3 levels
in patients with RA and Chronic Periodontitis in comparison
with Healthy controls.
Materials and Methods: This observational study was conducted on 90 subjects (42 Males and 48 Females) aged between
30-60 years. The subjects were selected from the out patient
ward of a tertiary referral care hospital. The selected subjects
were equally divided into three groups. Group I: Comprising
of 30 patients with RA and chronic periodontitis who were in
turn, subdivided into Group I- A (n=15) –Patients just diagnosed
with RA and Group I- B (n=15) Patients under medications
for more than three months. Group II: Patients with Chronic
Periodontitis (n=30) and Group III: Healthy Controls (n=30)
Intergroup comparison for continuous data was done by Oneway analysis of variance test followed by Bonferroni’s post-hoc
test. Intragroup comparison for continuous data was done by
paired t-test.
Results: Intergroup comparison between Group I and Group
II did not show any statistical difference pertaining to the
clinical parameters except for the Gingival Index (GI) which was
found to be higher in Group II (Mean= 2.07) when compared
to Group I (Mean=1.59). Intragroup comparison between Group
IA and Group IB was statistically significant for GI, Plaque
Index (PI), and Clinical Attachment Levels (CAL). Intragroup
comparison between Group I-A and Group I-B showed that
both Porphyromonas gingivalis and Pentraxin 3 Levels were
higher in Group I- A.
Conclusion: In this study, it was observed that there was a
positive association between Porphyromonas gingivalis and
Pentraxin 3 levels in patients with rheumatoid arthritis and
periodontitis. |
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| ISSN: | 2249-782X 0973-709X |