Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study
Introduction: Periodontal diseases are inflammatory in nature involving interplay between the bacterial plaque and the microorganisms, with the response of the host playing a pivotal role in either attenuating or eliminating the disease. Rheumatoid Arthritis (RA) is also a chronic inflammatory di...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2017-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/9792/24412_CE(RA1)_F(T)_PF1(RB_SS)_PFA(RB_SS).pdf |
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| author | Shankar Gittaboyina Rekha Rani Koduganti Srisaila Datta Aedula Veerendra Nath Reddy Panthula Surya Prasanna Jammula Rajashree Dasari Himabindu Gireddy Manasa Ambati |
| author_facet | Shankar Gittaboyina Rekha Rani Koduganti Srisaila Datta Aedula Veerendra Nath Reddy Panthula Surya Prasanna Jammula Rajashree Dasari Himabindu Gireddy Manasa Ambati |
| author_sort | Shankar Gittaboyina |
| collection | DOAJ |
| description | Introduction: Periodontal diseases are inflammatory in nature
involving interplay between the bacterial plaque and the microorganisms, with the response of the host playing a pivotal role
in either attenuating or eliminating the disease. Rheumatoid
Arthritis (RA) is also a chronic inflammatory disease which
shares common risk factors with periodontitis. Porphyromonas
Gingivalis and Pentraxin 3 (an acute inflammatory protein) have
been observed to be associated with both the diseases.
Aim: This study was done to determine if there was any association between Pophyromonas Gingivalis and Pentraxin 3 levels
in patients with RA and Chronic Periodontitis in comparison
with Healthy controls.
Materials and Methods: This observational study was conducted on 90 subjects (42 Males and 48 Females) aged between
30-60 years. The subjects were selected from the out patient
ward of a tertiary referral care hospital. The selected subjects
were equally divided into three groups. Group I: Comprising
of 30 patients with RA and chronic periodontitis who were in
turn, subdivided into Group I- A (n=15) –Patients just diagnosed
with RA and Group I- B (n=15) Patients under medications
for more than three months. Group II: Patients with Chronic
Periodontitis (n=30) and Group III: Healthy Controls (n=30)
Intergroup comparison for continuous data was done by Oneway analysis of variance test followed by Bonferroni’s post-hoc
test. Intragroup comparison for continuous data was done by
paired t-test.
Results: Intergroup comparison between Group I and Group
II did not show any statistical difference pertaining to the
clinical parameters except for the Gingival Index (GI) which was
found to be higher in Group II (Mean= 2.07) when compared
to Group I (Mean=1.59). Intragroup comparison between Group
IA and Group IB was statistically significant for GI, Plaque
Index (PI), and Clinical Attachment Levels (CAL). Intragroup
comparison between Group I-A and Group I-B showed that
both Porphyromonas gingivalis and Pentraxin 3 Levels were
higher in Group I- A.
Conclusion: In this study, it was observed that there was a
positive association between Porphyromonas gingivalis and
Pentraxin 3 levels in patients with rheumatoid arthritis and
periodontitis. |
| first_indexed | 2024-12-22T09:45:52Z |
| format | Article |
| id | doaj.art-9f5aa9d4470c469492aa4647ed4a31e9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T09:45:52Z |
| publishDate | 2017-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-9f5aa9d4470c469492aa4647ed4a31e92022-12-21T18:30:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-05-01115ZC09ZC1210.7860/JCDR/2017/24412.9792Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational StudyShankar Gittaboyina0Rekha Rani Koduganti1Srisaila Datta Aedula2Veerendra Nath Reddy Panthula3Surya Prasanna Jammula4Rajashree Dasari5Himabindu Gireddy6Manasa Ambati7Postgraduate Student, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Professor and Head, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Professor and Head, Department of Rheumatology, KIMS, Secunderabad, Hyderabad, Telangana, India.Professor, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Professor, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Reader, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Reader, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Senior Lecturer, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Introduction: Periodontal diseases are inflammatory in nature involving interplay between the bacterial plaque and the microorganisms, with the response of the host playing a pivotal role in either attenuating or eliminating the disease. Rheumatoid Arthritis (RA) is also a chronic inflammatory disease which shares common risk factors with periodontitis. Porphyromonas Gingivalis and Pentraxin 3 (an acute inflammatory protein) have been observed to be associated with both the diseases. Aim: This study was done to determine if there was any association between Pophyromonas Gingivalis and Pentraxin 3 levels in patients with RA and Chronic Periodontitis in comparison with Healthy controls. Materials and Methods: This observational study was conducted on 90 subjects (42 Males and 48 Females) aged between 30-60 years. The subjects were selected from the out patient ward of a tertiary referral care hospital. The selected subjects were equally divided into three groups. Group I: Comprising of 30 patients with RA and chronic periodontitis who were in turn, subdivided into Group I- A (n=15) –Patients just diagnosed with RA and Group I- B (n=15) Patients under medications for more than three months. Group II: Patients with Chronic Periodontitis (n=30) and Group III: Healthy Controls (n=30) Intergroup comparison for continuous data was done by Oneway analysis of variance test followed by Bonferroni’s post-hoc test. Intragroup comparison for continuous data was done by paired t-test. Results: Intergroup comparison between Group I and Group II did not show any statistical difference pertaining to the clinical parameters except for the Gingival Index (GI) which was found to be higher in Group II (Mean= 2.07) when compared to Group I (Mean=1.59). Intragroup comparison between Group IA and Group IB was statistically significant for GI, Plaque Index (PI), and Clinical Attachment Levels (CAL). Intragroup comparison between Group I-A and Group I-B showed that both Porphyromonas gingivalis and Pentraxin 3 Levels were higher in Group I- A. Conclusion: In this study, it was observed that there was a positive association between Porphyromonas gingivalis and Pentraxin 3 levels in patients with rheumatoid arthritis and periodontitis.https://jcdr.net/articles/PDF/9792/24412_CE(RA1)_F(T)_PF1(RB_SS)_PFA(RB_SS).pdfclinical parameterspolymerase chain reactionquantikine enzyme linked immunosorbent assay |
| spellingShingle | Shankar Gittaboyina Rekha Rani Koduganti Srisaila Datta Aedula Veerendra Nath Reddy Panthula Surya Prasanna Jammula Rajashree Dasari Himabindu Gireddy Manasa Ambati Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study Journal of Clinical and Diagnostic Research clinical parameters polymerase chain reaction quantikine enzyme linked immunosorbent assay |
| title | Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study |
| title_full | Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study |
| title_fullStr | Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study |
| title_full_unstemmed | Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study |
| title_short | Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study |
| title_sort | estimation of pentraxin 3 and porphyromonas gingivalis levels in patients with rheumatoid arthritis and periodontitis an observational study |
| topic | clinical parameters polymerase chain reaction quantikine enzyme linked immunosorbent assay |
| url | https://jcdr.net/articles/PDF/9792/24412_CE(RA1)_F(T)_PF1(RB_SS)_PFA(RB_SS).pdf |
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