In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

Proteasome-catalyzed peptide splicing (PCPS) of cancer-driving antigens could generate attractive neoepitopes to be targeted by T cell receptor (TCR)-based adoptive T cell therapy. Based on a spliced peptide prediction algorithm, TCRs were generated against putative KRASG12V- and RAC2P29L-derived ne...

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Bibliographic Details
Main Authors: Gerald Willimsky, Christin Beier, Lena Immisch, George Papafotiou, Vivian Scheuplein, Andrean Goede, Hermann-Georg Holzhütter, Thomas Blankenstein, Peter M Kloetzel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
TCR gene therapy
proteasome processing
spliced epitopes
Online Access:https://elifesciences.org/articles/62019

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