Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma
Epithelial ovarian carcinoma is the most predominant type of ovarian carcinoma, the deadliest gynecologic malignancy. It is typically diagnosed late when the cancer has already metastasized. Transcoelomic metastasis is the most predominant mechanism of dissemination from epithelial ovarian carcinoma...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-11-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/10/11/444 |
| _version_ | 1797727865824870400 |
|---|---|
| author | Maria V. Barbolina |
| author_facet | Maria V. Barbolina |
| author_sort | Maria V. Barbolina |
| collection | DOAJ |
| description | Epithelial ovarian carcinoma is the most predominant type of ovarian carcinoma, the deadliest gynecologic malignancy. It is typically diagnosed late when the cancer has already metastasized. Transcoelomic metastasis is the most predominant mechanism of dissemination from epithelial ovarian carcinoma, although both hematogenously and lymphogenously spread metastases also occur. In this review, we describe molecular mechanisms known to regulate organ-specific metastasis from epithelial ovarian carcinoma. We begin by discussing the sites colonized by metastatic ovarian carcinoma and rank them in the order of prevalence. Next, we review the mechanisms regulating the transcoelomic metastasis. Within this chapter, we specifically focus on the mechanisms that were demonstrated to regulate peritoneal adhesion—one of the first steps in the transcoelomic metastatic cascade. Furthermore, we describe mechanisms of the transcoelomic metastasis known to regulate colonization of specific sites within the peritoneal cavity, including the omentum. Mechanisms underlying hematogenous and lymphogenous metastatic spread are less comprehensively studied in ovarian cancer, and we summarize mechanisms that were identified to date. Lastly, we discuss the outcomes of the clinical trials that attempted to target some of the mechanisms described in this review. |
| first_indexed | 2024-03-12T11:05:41Z |
| format | Article |
| id | doaj.art-9f5b67ce68b344b9b56840d9d3b32605 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T11:05:41Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9f5b67ce68b344b9b56840d9d3b326052023-09-02T03:57:51ZengMDPI AGCancers2072-66942018-11-01101144410.3390/cancers10110444cancers10110444Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian CarcinomaMaria V. Barbolina0Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USAEpithelial ovarian carcinoma is the most predominant type of ovarian carcinoma, the deadliest gynecologic malignancy. It is typically diagnosed late when the cancer has already metastasized. Transcoelomic metastasis is the most predominant mechanism of dissemination from epithelial ovarian carcinoma, although both hematogenously and lymphogenously spread metastases also occur. In this review, we describe molecular mechanisms known to regulate organ-specific metastasis from epithelial ovarian carcinoma. We begin by discussing the sites colonized by metastatic ovarian carcinoma and rank them in the order of prevalence. Next, we review the mechanisms regulating the transcoelomic metastasis. Within this chapter, we specifically focus on the mechanisms that were demonstrated to regulate peritoneal adhesion—one of the first steps in the transcoelomic metastatic cascade. Furthermore, we describe mechanisms of the transcoelomic metastasis known to regulate colonization of specific sites within the peritoneal cavity, including the omentum. Mechanisms underlying hematogenous and lymphogenous metastatic spread are less comprehensively studied in ovarian cancer, and we summarize mechanisms that were identified to date. Lastly, we discuss the outcomes of the clinical trials that attempted to target some of the mechanisms described in this review.https://www.mdpi.com/2072-6694/10/11/444ovarian cancerorgan-specific metastasesperitoneal adhesionmesotheliumomentumperitoneal walllymph nodeliverlunggene expression |
| spellingShingle | Maria V. Barbolina Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma Cancers ovarian cancer organ-specific metastases peritoneal adhesion mesothelium omentum peritoneal wall lymph node liver lung gene expression |
| title | Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma |
| title_full | Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma |
| title_fullStr | Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma |
| title_full_unstemmed | Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma |
| title_short | Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma |
| title_sort | molecular mechanisms regulating organ specific metastases in epithelial ovarian carcinoma |
| topic | ovarian cancer organ-specific metastases peritoneal adhesion mesothelium omentum peritoneal wall lymph node liver lung gene expression |
| url | https://www.mdpi.com/2072-6694/10/11/444 |
| work_keys_str_mv | AT mariavbarbolina molecularmechanismsregulatingorganspecificmetastasesinepithelialovariancarcinoma |