Serum amyloid A in cats with renal azotemia
Background and Aim: The concentration of the feline acute-phase protein serum amyloid A (SAA) increases in cats with acute inflammatory diseases. However, it is unclear whether SAA concentration increases in cats with azotemic kidney disease or whether it can aid in differentiating acute kidney inju...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Veterinary World
2023-08-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | https://www.veterinaryworld.org/Vol.16/August-2023/13.pdf |
| _version_ | 1797740737769504768 |
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| author | Laura Degenhardt Roswitha Dorsch Katrin Hartmann René Dörfelt |
| author_facet | Laura Degenhardt Roswitha Dorsch Katrin Hartmann René Dörfelt |
| author_sort | Laura Degenhardt |
| collection | DOAJ |
| description | Background and Aim: The concentration of the feline acute-phase protein serum amyloid A (SAA) increases in cats with acute inflammatory diseases. However, it is unclear whether SAA concentration increases in cats with azotemic kidney disease or whether it can aid in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). Similarly, whether SAA concentration can be used as a prognostic marker is also unclear. Therefore, this study aimed to evaluate the SAA concentrations in cats with azotemic kidney disease and determine whether SAA concentrations can be used to differentiate between AKI, CKD, and “acute on CKD” (AoC). In addition, we evaluated whether SAA concentration could serve as a prognostic parameter. Moreover, we determined the correlations between SAA concentration and temperature; creatinine, urea, and albumin concentrations; leukocyte count; and urine protein/creatinine (UP/C).
Materials and Methods: Forty-eight client-owned azotemic cats (creatinine >250 μmol/L) were included in this prospective study. Cats with pre- and post-renal azotemia were excluded from the study. The causes of azotemia were differentiated into AKI, CKD, and AoC. The SAA concentrations were analyzed through turbidimetric immunoassay at the time of admission. Data were analyzed using the Mann-Whitney U, Kruskal-Wallis, Chi-Square, Fisher’s exact, and Spearman correlation tests. p ≤ 0.05 was considered statistically significant.
Results: Serum amyloid A concentration increased in 5/12 cats with AKI, 7/22 cats with CKD, and 9/14 cats with AoC (p = 0.234). The median SAA concentration in cats with AKI, CKD, and AoC whose SAA concentration was ≥5 mg/L was 174 mg/L (10-281 mg/L), 125 mg/L (6-269 mg/L), and 143 mg/L (7-316 mg/L), respectively (p = 0.697), with no significant differences observed between the groups. The median SAA concentration did not differ significantly between survivors (125 mg/L, 10-316 mg/L) and non-survivors (149 mg/L, 6-281 mg/L; p = 0.915) with SAA concentration ≥5 mg/L.
Conclusion: Serum amyloid A concentration increased in 44% of the cats with azotemia. However, it cannot be used to differentiate AKI from CKD or as a prognostic marker. Serum amyloid A concentration was correlated with neutrophil count, albumin concentration, and UP/C, and the presence of comorbidities may influence SAA concentration. |
| first_indexed | 2024-03-12T14:16:44Z |
| format | Article |
| id | doaj.art-9f5e213cb7374a828f36bffe7983ddee |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-03-12T14:16:44Z |
| publishDate | 2023-08-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-9f5e213cb7374a828f36bffe7983ddee2023-08-20T10:45:43ZengVeterinary WorldVeterinary World0972-89882231-09162023-08-011681673168110.14202/vetworld.2023.1673-1681Serum amyloid A in cats with renal azotemiaLaura Degenhardt0Roswitha Dorsch1https://orcid.org/0000-0002-7508-5411Katrin Hartmann2https://orcid.org/0000-0002-5256-863XRené Dörfelt3https://orcid.org/0000-0003-1831-377XLMU Small Animal Clinic, Center for Clinical Veterinary Medicine, LMU München, Veterinärstraße 13, 80539, Munich, Germany. LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, LMU München, Veterinärstraße 13, 80539, Munich, Germany. LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, LMU München, Veterinärstraße 13, 80539, Munich, Germany. LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, LMU München, Veterinärstraße 13, 80539, Munich, Germany.Background and Aim: The concentration of the feline acute-phase protein serum amyloid A (SAA) increases in cats with acute inflammatory diseases. However, it is unclear whether SAA concentration increases in cats with azotemic kidney disease or whether it can aid in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). Similarly, whether SAA concentration can be used as a prognostic marker is also unclear. Therefore, this study aimed to evaluate the SAA concentrations in cats with azotemic kidney disease and determine whether SAA concentrations can be used to differentiate between AKI, CKD, and “acute on CKD” (AoC). In addition, we evaluated whether SAA concentration could serve as a prognostic parameter. Moreover, we determined the correlations between SAA concentration and temperature; creatinine, urea, and albumin concentrations; leukocyte count; and urine protein/creatinine (UP/C). Materials and Methods: Forty-eight client-owned azotemic cats (creatinine >250 μmol/L) were included in this prospective study. Cats with pre- and post-renal azotemia were excluded from the study. The causes of azotemia were differentiated into AKI, CKD, and AoC. The SAA concentrations were analyzed through turbidimetric immunoassay at the time of admission. Data were analyzed using the Mann-Whitney U, Kruskal-Wallis, Chi-Square, Fisher’s exact, and Spearman correlation tests. p ≤ 0.05 was considered statistically significant. Results: Serum amyloid A concentration increased in 5/12 cats with AKI, 7/22 cats with CKD, and 9/14 cats with AoC (p = 0.234). The median SAA concentration in cats with AKI, CKD, and AoC whose SAA concentration was ≥5 mg/L was 174 mg/L (10-281 mg/L), 125 mg/L (6-269 mg/L), and 143 mg/L (7-316 mg/L), respectively (p = 0.697), with no significant differences observed between the groups. The median SAA concentration did not differ significantly between survivors (125 mg/L, 10-316 mg/L) and non-survivors (149 mg/L, 6-281 mg/L; p = 0.915) with SAA concentration ≥5 mg/L. Conclusion: Serum amyloid A concentration increased in 44% of the cats with azotemia. However, it cannot be used to differentiate AKI from CKD or as a prognostic marker. Serum amyloid A concentration was correlated with neutrophil count, albumin concentration, and UP/C, and the presence of comorbidities may influence SAA concentration.https://www.veterinaryworld.org/Vol.16/August-2023/13.pdfacute kidney injuryacute-phase proteinchronic kidney diseaseinternational renal interest society gradinguremia. |
| spellingShingle | Laura Degenhardt Roswitha Dorsch Katrin Hartmann René Dörfelt Serum amyloid A in cats with renal azotemia Veterinary World acute kidney injury acute-phase protein chronic kidney disease international renal interest society grading uremia. |
| title | Serum amyloid A in cats with renal azotemia |
| title_full | Serum amyloid A in cats with renal azotemia |
| title_fullStr | Serum amyloid A in cats with renal azotemia |
| title_full_unstemmed | Serum amyloid A in cats with renal azotemia |
| title_short | Serum amyloid A in cats with renal azotemia |
| title_sort | serum amyloid a in cats with renal azotemia |
| topic | acute kidney injury acute-phase protein chronic kidney disease international renal interest society grading uremia. |
| url | https://www.veterinaryworld.org/Vol.16/August-2023/13.pdf |
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