Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction
Abstract Aims Evidence on the association between ambient temperature and the onset of acute heart failure (AHF) is scarce and mixed. We sought to investigate the incidence of AHF admissions based on ambient temperature change, with particular interest in detecting the difference between AHF with pr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.14010 |
| _version_ | 1797794304417071104 |
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| author | Takahiro Jimba Shun Kohsaka Masao Yamasaki Toshiaki Otsuka Kazumasa Harada Yasuyuki Shiraishi Shinji Koba Makoto Takei Takashi Kohno Kenichi Matsushita Tetsuro Miyazaki Satoshi Kodera Shigeto Tsukamoto Kiyoshi Iida Akito Shindo Daisuke Kitano Takeshi Yamamoto Ken Nagao Morimasa Takayama Tokyo CCU Network Scientific Committee |
| author_facet | Takahiro Jimba Shun Kohsaka Masao Yamasaki Toshiaki Otsuka Kazumasa Harada Yasuyuki Shiraishi Shinji Koba Makoto Takei Takashi Kohno Kenichi Matsushita Tetsuro Miyazaki Satoshi Kodera Shigeto Tsukamoto Kiyoshi Iida Akito Shindo Daisuke Kitano Takeshi Yamamoto Ken Nagao Morimasa Takayama Tokyo CCU Network Scientific Committee |
| author_sort | Takahiro Jimba |
| collection | DOAJ |
| description | Abstract Aims Evidence on the association between ambient temperature and the onset of acute heart failure (AHF) is scarce and mixed. We sought to investigate the incidence of AHF admissions based on ambient temperature change, with particular interest in detecting the difference between AHF with preserved (HFpEF), mildly reduced (HFmrEF), and reduced ejection fraction (HFrEF). Methods and results Individualized AHF admission data from January 2015 to December 2016 were obtained from a multicentre registry (Tokyo CCU Network Database). The primary event was the daily number of admissions. A linear regression model, using the lowest ambient temperature as the explanatory variable, was selected for the best‐estimate model. We also applied the cubic spline model using five knots according to the percentiles of the distribution of the lowest ambient temperature. We divided the entire population into HFpEF + HFmrEF and HFrEF for comparison. In addition, the in‐hospital treatment and mortality rates were obtained according to the interquartile ranges (IQRs) of the lowest ambient temperature (IQR1 <5.5°C; IQR25.5–13.3°C; IQR3 13.3–19.7°C; and IQR4 >19.7°C). The number of admissions for HFpEF, HFmrEF and HFrEF were 2736 (36%), 1539 (20%), and 3354 (44%), respectively. The lowest ambient temperature on the admission day was inversely correlated with the admission frequency for both HFpEF + HFmrEF and HFrEF patients, with a stronger correlation in patients with HFpEF + HFmrEF (R2 = 0.25 vs. 0.05, P < 0.001). In the sensitivity analysis, the decrease in the ambient temperature was associated with the greatest incremental increases in HFpEF, followed by HFmrEF and HFrEF patients (3.5% vs. 2.8% vs. 1.5% per −1°C, P < 0.001), with marked increase in admissions of hypertensive patients (systolic blood pressure >140 mmHg vs. 140–100 mmHg vs. <100 mmHg, 3.0% vs. 2.0% vs. 0.8% per −1°C, P for interaction <0.001). A mediator analysis indicated the presence of the mediator effect of systolic blood pressure. The in‐hospital mortality rate (7.5%) did not significantly change according to ambient temperature (P = 0.62). Conclusions Lower ambient temperature was associated with higher frequency of AHF admissions, and the effect was more pronounced in HFpEF and HFmrEF patients than in those with HFrEF. |
| first_indexed | 2024-03-13T03:00:47Z |
| format | Article |
| id | doaj.art-9f5fb655b7b94f7a98c932d0abaa8061 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-03-13T03:00:47Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-9f5fb655b7b94f7a98c932d0abaa80612023-06-27T14:49:57ZengWileyESC Heart Failure2055-58222022-10-01952899290810.1002/ehf2.14010Association of ambient temperature and acute heart failure with preserved and reduced ejection fractionTakahiro Jimba0Shun Kohsaka1Masao Yamasaki2Toshiaki Otsuka3Kazumasa Harada4Yasuyuki Shiraishi5Shinji Koba6Makoto Takei7Takashi Kohno8Kenichi Matsushita9Tetsuro Miyazaki10Satoshi Kodera11Shigeto Tsukamoto12Kiyoshi Iida13Akito Shindo14Daisuke Kitano15Takeshi Yamamoto16Ken Nagao17Morimasa Takayama18Tokyo CCU Network Scientific CommitteeTokyo CCU Network Scientific Committee/NTT Medical Center Tokyo Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee/NTT Medical Center Tokyo Tokyo JapanTokyo CCU Network Scientific Committee/Nippon Medical School Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanTokyo CCU Network Scientific Committee Tokyo JapanAbstract Aims Evidence on the association between ambient temperature and the onset of acute heart failure (AHF) is scarce and mixed. We sought to investigate the incidence of AHF admissions based on ambient temperature change, with particular interest in detecting the difference between AHF with preserved (HFpEF), mildly reduced (HFmrEF), and reduced ejection fraction (HFrEF). Methods and results Individualized AHF admission data from January 2015 to December 2016 were obtained from a multicentre registry (Tokyo CCU Network Database). The primary event was the daily number of admissions. A linear regression model, using the lowest ambient temperature as the explanatory variable, was selected for the best‐estimate model. We also applied the cubic spline model using five knots according to the percentiles of the distribution of the lowest ambient temperature. We divided the entire population into HFpEF + HFmrEF and HFrEF for comparison. In addition, the in‐hospital treatment and mortality rates were obtained according to the interquartile ranges (IQRs) of the lowest ambient temperature (IQR1 <5.5°C; IQR25.5–13.3°C; IQR3 13.3–19.7°C; and IQR4 >19.7°C). The number of admissions for HFpEF, HFmrEF and HFrEF were 2736 (36%), 1539 (20%), and 3354 (44%), respectively. The lowest ambient temperature on the admission day was inversely correlated with the admission frequency for both HFpEF + HFmrEF and HFrEF patients, with a stronger correlation in patients with HFpEF + HFmrEF (R2 = 0.25 vs. 0.05, P < 0.001). In the sensitivity analysis, the decrease in the ambient temperature was associated with the greatest incremental increases in HFpEF, followed by HFmrEF and HFrEF patients (3.5% vs. 2.8% vs. 1.5% per −1°C, P < 0.001), with marked increase in admissions of hypertensive patients (systolic blood pressure >140 mmHg vs. 140–100 mmHg vs. <100 mmHg, 3.0% vs. 2.0% vs. 0.8% per −1°C, P for interaction <0.001). A mediator analysis indicated the presence of the mediator effect of systolic blood pressure. The in‐hospital mortality rate (7.5%) did not significantly change according to ambient temperature (P = 0.62). Conclusions Lower ambient temperature was associated with higher frequency of AHF admissions, and the effect was more pronounced in HFpEF and HFmrEF patients than in those with HFrEF.https://doi.org/10.1002/ehf2.14010Acute heart failureAmbient temperatureHeart failure with preserved ejection fractionHeart failure with reduced ejection fractionHypertension |
| spellingShingle | Takahiro Jimba Shun Kohsaka Masao Yamasaki Toshiaki Otsuka Kazumasa Harada Yasuyuki Shiraishi Shinji Koba Makoto Takei Takashi Kohno Kenichi Matsushita Tetsuro Miyazaki Satoshi Kodera Shigeto Tsukamoto Kiyoshi Iida Akito Shindo Daisuke Kitano Takeshi Yamamoto Ken Nagao Morimasa Takayama Tokyo CCU Network Scientific Committee Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction ESC Heart Failure Acute heart failure Ambient temperature Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Hypertension |
| title | Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction |
| title_full | Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction |
| title_fullStr | Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction |
| title_full_unstemmed | Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction |
| title_short | Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction |
| title_sort | association of ambient temperature and acute heart failure with preserved and reduced ejection fraction |
| topic | Acute heart failure Ambient temperature Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Hypertension |
| url | https://doi.org/10.1002/ehf2.14010 |
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