A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban
A 22-year-old woman was admitted to the hospital with complaints of headache and vomiting. Radiological examinations revealed cerebral sinus venous thromboses, pulmonary thromboembolism, and cavities in the left upper lung. Pulmonary tuberculosis was diagnosed based on sputum and gastric aspirate cu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007122001587 |
| _version_ | 1811199271454638080 |
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| author | Koichi Nishino Takashi Akimoto Hideyuki Mitsuoka Yutaka Terajima Yuta Arai Yoshihiro Masui Tomoyasu Mimori Kengo Koike Kazuhisa Takahashi Mitsuaki Sekiya |
| author_facet | Koichi Nishino Takashi Akimoto Hideyuki Mitsuoka Yutaka Terajima Yuta Arai Yoshihiro Masui Tomoyasu Mimori Kengo Koike Kazuhisa Takahashi Mitsuaki Sekiya |
| author_sort | Koichi Nishino |
| collection | DOAJ |
| description | A 22-year-old woman was admitted to the hospital with complaints of headache and vomiting. Radiological examinations revealed cerebral sinus venous thromboses, pulmonary thromboembolism, and cavities in the left upper lung. Pulmonary tuberculosis was diagnosed based on sputum and gastric aspirate culture. Heparin followed by warfarin was administered. Anti-tuberculosis agents including rifampicin were also initiated. Since the effect of warfarin did not reach the therapeutic level because of interaction with rifampicin, edoxaban was administered and thromboses were ameliorated. This report illustrates rare thrombotic complications in a TB-induced hypercoagulable state and the potential benefits and safety of edoxaban in combination with rifampicin. |
| first_indexed | 2024-04-12T01:45:05Z |
| format | Article |
| id | doaj.art-9f5fde132e76406f8452f64cd3839e44 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-12T01:45:05Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-9f5fde132e76406f8452f64cd3839e442022-12-22T03:53:05ZengElsevierRespiratory Medicine Case Reports2213-00712022-01-0139101736A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with EdoxabanKoichi Nishino0Takashi Akimoto1Hideyuki Mitsuoka2Yutaka Terajima3Yuta Arai4Yoshihiro Masui5Tomoyasu Mimori6Kengo Koike7Kazuhisa Takahashi8Mitsuaki Sekiya9Department of Respiratory Medicine, Saiseikai Kawaguchi General Hospital, Japan; Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Japan; Corresponding author. Department of respiratory medicine, Saiseikai Kawaguchi General Hospital, 5-11-5, Nishi-kawaguchi, Japan.Department of Respiratory Medicine, Saiseikai Kawaguchi General Hospital, Japan; Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, JapanDepartment of Neurosurgery, Saiseikai Kawaguchi General Hospital, JapanDepartment of Cardiology, Saiseikai Kazo Hospital, JapanDepartment of Respiratory Medicine, Saiseikai Kawaguchi General Hospital, Japan; Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, JapanDepartment of Respiratory Medicine, Saiseikai Kawaguchi General Hospital, Japan; Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, JapanDepartment of Respiratory Medicine, Saiseikai Kawaguchi General Hospital, Japan; Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, JapanDepartment of Respiratory Medicine, Saiseikai Kawaguchi General Hospital, Japan; Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, JapanDivision of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, JapanDepartment of Respiratory Medicine, Saiseikai Kawaguchi General Hospital, Japan; Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, JapanA 22-year-old woman was admitted to the hospital with complaints of headache and vomiting. Radiological examinations revealed cerebral sinus venous thromboses, pulmonary thromboembolism, and cavities in the left upper lung. Pulmonary tuberculosis was diagnosed based on sputum and gastric aspirate culture. Heparin followed by warfarin was administered. Anti-tuberculosis agents including rifampicin were also initiated. Since the effect of warfarin did not reach the therapeutic level because of interaction with rifampicin, edoxaban was administered and thromboses were ameliorated. This report illustrates rare thrombotic complications in a TB-induced hypercoagulable state and the potential benefits and safety of edoxaban in combination with rifampicin.http://www.sciencedirect.com/science/article/pii/S2213007122001587Cerebral venous sinus thrombosisPulmonary thromboembolismPulmonary tuberculosisVenous thrombosisDirect oral anticoagulantEdoxaban |
| spellingShingle | Koichi Nishino Takashi Akimoto Hideyuki Mitsuoka Yutaka Terajima Yuta Arai Yoshihiro Masui Tomoyasu Mimori Kengo Koike Kazuhisa Takahashi Mitsuaki Sekiya A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban Respiratory Medicine Case Reports Cerebral venous sinus thrombosis Pulmonary thromboembolism Pulmonary tuberculosis Venous thrombosis Direct oral anticoagulant Edoxaban |
| title | A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban |
| title_full | A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban |
| title_fullStr | A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban |
| title_full_unstemmed | A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban |
| title_short | A Case of Tuberculosis-related Cerebral Venous Sinus Thrombosis and Pulmonary Thromboembolism Successfully Treated with Edoxaban |
| title_sort | case of tuberculosis related cerebral venous sinus thrombosis and pulmonary thromboembolism successfully treated with edoxaban |
| topic | Cerebral venous sinus thrombosis Pulmonary thromboembolism Pulmonary tuberculosis Venous thrombosis Direct oral anticoagulant Edoxaban |
| url | http://www.sciencedirect.com/science/article/pii/S2213007122001587 |
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