Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients
Abstract Background Neuropsychiatric manifestations of lupus (NPSLE) are considered one of the major and most devastating lupus manifestations. The aim of this study was to assess the neuropsychiatric manifestations in systemic lupus erythematosus (SLE) patients and estimate the effectiveness of bra...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | Middle East Current Psychiatry |
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| Online Access: | https://doi.org/10.1186/s43045-023-00303-7 |
| _version_ | 1827956988312551424 |
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| author | Dina A. Shahin Khaled M. F. Hegazy Mohammed Elsherif Nagy A. Sayed-Ahmed Mohamed Elwasify Eman Helmy Ahmed Abdel Khalek Abdel Razek Samar Tharwat |
| author_facet | Dina A. Shahin Khaled M. F. Hegazy Mohammed Elsherif Nagy A. Sayed-Ahmed Mohamed Elwasify Eman Helmy Ahmed Abdel Khalek Abdel Razek Samar Tharwat |
| author_sort | Dina A. Shahin |
| collection | DOAJ |
| description | Abstract Background Neuropsychiatric manifestations of lupus (NPSLE) are considered one of the major and most devastating lupus manifestations. The aim of this study was to assess the neuropsychiatric manifestations in systemic lupus erythematosus (SLE) patients and estimate the effectiveness of brain magnetic resonance spectroscopy (MRS) and anti-ribosomal P antibody test in early detection of NPSLE. This cross-sectional study was carried out on 50 SLE patients. Demographic, clinical, and therapeutic data were assessed. All patients were subjected to thorough rheumatological and neuropsychiatric evaluation. Serologic tests included antinuclear antibodies, anti-double-stranded DNA, and anti-ribosomal P protein antibodies. Radiologic evaluation included brain MRS. Results The mean age was 26.9 ± 98.9 years; the median disease duration was 18 (0–108) months. Headache was the most common neurological symptom (40%). Depression was not detected in 29 patients (58%), mild in 15 patients (30%), and moderate in 6 patients (12%). Anti-ribosomal P antibody titer was significantly elevated in patients with active in comparison with those with inactive lupus disease (p = 0.026). Brain MRS showed a statistically significant reduction in N-acetylaspartate creatine ratio (NAA/Cr) among patients with active lupus disease (p = 0.015) with a statistically significant increase in choline creatine ratio (Cho/Cr) among patients with inactive lupus disease (p = 0.049). There was a statistically significant negative correlation between the level of NAA/Cr and anti-ribosomal P antibody titer among patients with active lupus disease (p < 0.001). Conclusions Headache is the most common neurological manifestation among SLE patients. Anti-ribosomal P antibody titer is elevated in active SLE patients. The changes of NAA/Cr and Cho/Cr in brain MRS can be of help to differentiate between the active and inactive SLE. |
| first_indexed | 2024-04-09T15:13:07Z |
| format | Article |
| id | doaj.art-9f5ff8c3a17549f5b5a4f5a5ccdab526 |
| institution | Directory Open Access Journal |
| issn | 2090-5416 |
| language | English |
| last_indexed | 2024-04-09T15:13:07Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Current Psychiatry |
| spelling | doaj.art-9f5ff8c3a17549f5b5a4f5a5ccdab5262023-04-30T11:05:59ZengSpringerOpenMiddle East Current Psychiatry2090-54162023-04-0130111010.1186/s43045-023-00303-7Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patientsDina A. Shahin0Khaled M. F. Hegazy1Mohammed Elsherif2Nagy A. Sayed-Ahmed3Mohamed Elwasify4Eman Helmy5Ahmed Abdel Khalek Abdel Razek6Samar Tharwat7Rheumatology and Immunology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura UniversityRheumatology and Immunology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura UniversityDepartment of Neurology, Faculty of Medicine, Mansoura UniversityMansoura Nephrology and Dialysis Unit (MNDU), Internal Medicine Department, Faculty of Medicine, Mansoura UniversityDepartment of Psychiatry, Faculty of Medicine, Mansoura UniversityDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Mansoura UniversityRheumatology and Immunology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura UniversityAbstract Background Neuropsychiatric manifestations of lupus (NPSLE) are considered one of the major and most devastating lupus manifestations. The aim of this study was to assess the neuropsychiatric manifestations in systemic lupus erythematosus (SLE) patients and estimate the effectiveness of brain magnetic resonance spectroscopy (MRS) and anti-ribosomal P antibody test in early detection of NPSLE. This cross-sectional study was carried out on 50 SLE patients. Demographic, clinical, and therapeutic data were assessed. All patients were subjected to thorough rheumatological and neuropsychiatric evaluation. Serologic tests included antinuclear antibodies, anti-double-stranded DNA, and anti-ribosomal P protein antibodies. Radiologic evaluation included brain MRS. Results The mean age was 26.9 ± 98.9 years; the median disease duration was 18 (0–108) months. Headache was the most common neurological symptom (40%). Depression was not detected in 29 patients (58%), mild in 15 patients (30%), and moderate in 6 patients (12%). Anti-ribosomal P antibody titer was significantly elevated in patients with active in comparison with those with inactive lupus disease (p = 0.026). Brain MRS showed a statistically significant reduction in N-acetylaspartate creatine ratio (NAA/Cr) among patients with active lupus disease (p = 0.015) with a statistically significant increase in choline creatine ratio (Cho/Cr) among patients with inactive lupus disease (p = 0.049). There was a statistically significant negative correlation between the level of NAA/Cr and anti-ribosomal P antibody titer among patients with active lupus disease (p < 0.001). Conclusions Headache is the most common neurological manifestation among SLE patients. Anti-ribosomal P antibody titer is elevated in active SLE patients. The changes of NAA/Cr and Cho/Cr in brain MRS can be of help to differentiate between the active and inactive SLE.https://doi.org/10.1186/s43045-023-00303-7Systemic lupus erythematosusNeuropsychiatric lupusAnti-ribosomal P antibodiesMRS |
| spellingShingle | Dina A. Shahin Khaled M. F. Hegazy Mohammed Elsherif Nagy A. Sayed-Ahmed Mohamed Elwasify Eman Helmy Ahmed Abdel Khalek Abdel Razek Samar Tharwat Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients Middle East Current Psychiatry Systemic lupus erythematosus Neuropsychiatric lupus Anti-ribosomal P antibodies MRS |
| title | Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients |
| title_full | Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients |
| title_fullStr | Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients |
| title_full_unstemmed | Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients |
| title_short | Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients |
| title_sort | neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients |
| topic | Systemic lupus erythematosus Neuropsychiatric lupus Anti-ribosomal P antibodies MRS |
| url | https://doi.org/10.1186/s43045-023-00303-7 |
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