PTEN regulates hematopoietic lineage plasticity via PU.1-dependent chromatin accessibility

PTEN regulates hematopoietic lineage plasticity via PU.1-dependent chromatin accessibility

Summary: PTEN loss in fetal liver hematopoietic stem cells (HSCs) leads to alterations in myeloid, T-, and B-lineage potentials and T-lineage acute lymphoblastic leukemia (T-ALL) development. To explore the mechanism underlying PTEN-regulated hematopoietic lineage choices, we carry out integrated as...

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Bibliographic Details
Main Authors: Zihan Xu, Libing He, Yilin Wu, Lu Yang, Cheng Li, Hong Wu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009786

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