Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease
Type 2 diabetes mellitus (T2DM) is closely related to the occurrence and progress of Parkinson's disease (PD), in which neurotoxicity caused by hyperglycemia and cerebral insulin resistance may play important roles, and the specific mechanism is not certain. Chronic hyperglycemia may lead to th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2023-06-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://cjcnn.org/index.php/cjcnn/article/view/2712 |
| _version_ | 1827859656095039488 |
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| author | WANG Min QIN Jie LI Lan⁃xin LI Xin CHEN Lei |
| author_facet | WANG Min QIN Jie LI Lan⁃xin LI Xin CHEN Lei |
| author_sort | WANG Min |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is closely related to the occurrence and progress of Parkinson's disease (PD), in which neurotoxicity caused by hyperglycemia and cerebral insulin resistance may play important roles, and the specific mechanism is not certain. Chronic hyperglycemia may lead to the injury of substantia nigra dopaminergic neuron by promoting oxidative stress, neuroinflammation, the formation of advanced glycation end products and endogenous neurotoxin. Moreover, insulin resistance may be involved in several pathways. This article mainly reviews the mechanism of T2DM increasing the risk of PD and provides guidance for the prevention and treatment of PD in patients with T2DM. |
| first_indexed | 2024-03-12T13:11:29Z |
| format | Article |
| id | doaj.art-9f61eb4d7cec4fa3b5da4047256e2b18 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-03-12T13:11:29Z |
| publishDate | 2023-06-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-9f61eb4d7cec4fa3b5da4047256e2b182023-08-28T01:29:02ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312023-06-0123656657010.3969/j.issn.1672⁃6731.2023.06.0162666Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's diseaseWANG Min0QIN Jie1LI Lan⁃xin2LI Xin3CHEN Lei4Grade 2020, Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin 300070, ChinaDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin 300350, ChinaGrade 2021, Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin 300070, ChinaDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin 300350, ChinaDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin 300350, ChinaType 2 diabetes mellitus (T2DM) is closely related to the occurrence and progress of Parkinson's disease (PD), in which neurotoxicity caused by hyperglycemia and cerebral insulin resistance may play important roles, and the specific mechanism is not certain. Chronic hyperglycemia may lead to the injury of substantia nigra dopaminergic neuron by promoting oxidative stress, neuroinflammation, the formation of advanced glycation end products and endogenous neurotoxin. Moreover, insulin resistance may be involved in several pathways. This article mainly reviews the mechanism of T2DM increasing the risk of PD and provides guidance for the prevention and treatment of PD in patients with T2DM.http://cjcnn.org/index.php/cjcnn/article/view/2712parkinson's diseasediabetes mellitus, type 2hyperglycemiainsulin resistancereview |
| spellingShingle | WANG Min QIN Jie LI Lan⁃xin LI Xin CHEN Lei Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease Chinese Journal of Contemporary Neurology and Neurosurgery parkinson's disease diabetes mellitus, type 2 hyperglycemia insulin resistance review |
| title | Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease |
| title_full | Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease |
| title_fullStr | Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease |
| title_full_unstemmed | Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease |
| title_short | Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease |
| title_sort | advance on mechanism of type 2 diabetes mellitus increasing the risk of parkinson s disease |
| topic | parkinson's disease diabetes mellitus, type 2 hyperglycemia insulin resistance review |
| url | http://cjcnn.org/index.php/cjcnn/article/view/2712 |
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