REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and z...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14143-9 |
| _version_ | 1830299793754161152 |
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| author | Shin-Haw Lee Sina Hadipour-Lakmehsari Harsha R. Murthy Natalie Gibb Tetsuaki Miyake Allen C. T. Teng Jake Cosme Jessica C. Yu Mark Moon SangHyun Lim Victoria Wong Peter Liu Filio Billia Rodrigo Fernandez-Gonzalez Igor Stagljar Parveen Sharma Thomas Kislinger Ian C. Scott Anthony O. Gramolini |
| author_facet | Shin-Haw Lee Sina Hadipour-Lakmehsari Harsha R. Murthy Natalie Gibb Tetsuaki Miyake Allen C. T. Teng Jake Cosme Jessica C. Yu Mark Moon SangHyun Lim Victoria Wong Peter Liu Filio Billia Rodrigo Fernandez-Gonzalez Igor Stagljar Parveen Sharma Thomas Kislinger Ian C. Scott Anthony O. Gramolini |
| author_sort | Shin-Haw Lee |
| collection | DOAJ |
| description | The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and zebrafish models. |
| first_indexed | 2024-12-19T08:15:24Z |
| format | Article |
| id | doaj.art-9f62361bf8a34f7da79df62e9762126b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:15:24Z |
| publishDate | 2020-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9f62361bf8a34f7da79df62e9762126b2022-12-21T20:29:30ZengNature PortfolioNature Communications2041-17232020-02-0111112010.1038/s41467-019-14143-9REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defectsShin-Haw Lee0Sina Hadipour-Lakmehsari1Harsha R. Murthy2Natalie Gibb3Tetsuaki Miyake4Allen C. T. Teng5Jake Cosme6Jessica C. Yu7Mark Moon8SangHyun Lim9Victoria Wong10Peter Liu11Filio Billia12Rodrigo Fernandez-Gonzalez13Igor Stagljar14Parveen Sharma15Thomas Kislinger16Ian C. Scott17Anthony O. Gramolini18Translational Biology and Engineering Program, Ted Rogers Centre for Heart ResearchTranslational Biology and Engineering Program, Ted Rogers Centre for Heart ResearchProgram in Developmental and Stem Cell Biology, The Hospital for Sick ChildrenProgram in Developmental and Stem Cell Biology, The Hospital for Sick ChildrenDepartment of Physiology, Faculty of Medicine, University of TorontoTranslational Biology and Engineering Program, Ted Rogers Centre for Heart ResearchTranslational Biology and Engineering Program, Ted Rogers Centre for Heart ResearchTranslational Biology and Engineering Program, Ted Rogers Centre for Heart ResearchDepartment of Physiology, Faculty of Medicine, University of TorontoDonnelly Centre, University of TorontoDonnelly Centre, University of TorontoOttawa Heart InstituteToronto General Research Institute, University Health NetworkTranslational Biology and Engineering Program, Ted Rogers Centre for Heart ResearchDonnelly Centre, University of TorontoDepartment of Physiology, Faculty of Medicine, University of TorontoDepartment of Medical Biophysics, University of TorontoProgram in Developmental and Stem Cell Biology, The Hospital for Sick ChildrenTranslational Biology and Engineering Program, Ted Rogers Centre for Heart ResearchThe sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and zebrafish models.https://doi.org/10.1038/s41467-019-14143-9 |
| spellingShingle | Shin-Haw Lee Sina Hadipour-Lakmehsari Harsha R. Murthy Natalie Gibb Tetsuaki Miyake Allen C. T. Teng Jake Cosme Jessica C. Yu Mark Moon SangHyun Lim Victoria Wong Peter Liu Filio Billia Rodrigo Fernandez-Gonzalez Igor Stagljar Parveen Sharma Thomas Kislinger Ian C. Scott Anthony O. Gramolini REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects Nature Communications |
| title | REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects |
| title_full | REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects |
| title_fullStr | REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects |
| title_full_unstemmed | REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects |
| title_short | REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects |
| title_sort | reep5 depletion causes sarco endoplasmic reticulum vacuolization and cardiac functional defects |
| url | https://doi.org/10.1038/s41467-019-14143-9 |
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