Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation
Combined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling and increasingly relevant therapeutic possibility for an ever-growing number of patients who would benefit from both durable renal replacement and cure of the underlying cause of their ren...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351717/full |
| _version_ | 1797294281894920192 |
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| author | Daniel L. Eisenson Hayato Iwase Weili Chen Yu Hisadome Wanxing Cui Michelle R. Santillan Alexander C. Schulick Du Gu Amanda Maxwell Kristy Koenig Zhaoli Sun Daniel Warren Kazuhiko Yamada |
| author_facet | Daniel L. Eisenson Hayato Iwase Weili Chen Yu Hisadome Wanxing Cui Michelle R. Santillan Alexander C. Schulick Du Gu Amanda Maxwell Kristy Koenig Zhaoli Sun Daniel Warren Kazuhiko Yamada |
| author_sort | Daniel L. Eisenson |
| collection | DOAJ |
| description | Combined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling and increasingly relevant therapeutic possibility for an ever-growing number of patients who would benefit from both durable renal replacement and cure of the underlying cause of their renal insufficiency: diabetes. Here we briefly review immune barriers to islet transplantation, highlight preclinical progress in the field, and summarize our experience with combined islet and kidney xenotransplantation, including both challenges with islet-kidney composite grafts as well as our recent success with sequential kidney followed by islet xenotransplantation in a pig-to-baboon model. |
| first_indexed | 2024-03-07T21:27:59Z |
| format | Article |
| id | doaj.art-9f62dea3c4f8441f8ad8dce9a809b9d7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T21:27:59Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9f62dea3c4f8441f8ad8dce9a809b9d72024-02-27T04:23:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13517171351717Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantationDaniel L. Eisenson0Hayato Iwase1Weili Chen2Yu Hisadome3Wanxing Cui4Michelle R. Santillan5Alexander C. Schulick6Du Gu7Amanda Maxwell8Kristy Koenig9Zhaoli Sun10Daniel Warren11Kazuhiko Yamada12Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesCell Therapy and Manufacturing, Medstar Georgetown University Hospital, Washington DC, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesResearch Animal Resources, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesCombined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling and increasingly relevant therapeutic possibility for an ever-growing number of patients who would benefit from both durable renal replacement and cure of the underlying cause of their renal insufficiency: diabetes. Here we briefly review immune barriers to islet transplantation, highlight preclinical progress in the field, and summarize our experience with combined islet and kidney xenotransplantation, including both challenges with islet-kidney composite grafts as well as our recent success with sequential kidney followed by islet xenotransplantation in a pig-to-baboon model.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351717/fullislet xenotransplantationislet-kidneyxenogeneic immune responsetolerancexenotransplantation |
| spellingShingle | Daniel L. Eisenson Hayato Iwase Weili Chen Yu Hisadome Wanxing Cui Michelle R. Santillan Alexander C. Schulick Du Gu Amanda Maxwell Kristy Koenig Zhaoli Sun Daniel Warren Kazuhiko Yamada Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation Frontiers in Immunology islet xenotransplantation islet-kidney xenogeneic immune response tolerance xenotransplantation |
| title | Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation |
| title_full | Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation |
| title_fullStr | Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation |
| title_full_unstemmed | Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation |
| title_short | Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation |
| title_sort | combined islet and kidney xenotransplantation for diabetic nephropathy an update in ongoing research for a clinically relevant application of porcine islet transplantation |
| topic | islet xenotransplantation islet-kidney xenogeneic immune response tolerance xenotransplantation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351717/full |
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