Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction
Abstract Background Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-inflammatory activation. We aimed to investigate the hematopoietic-inflammatory activation and the outcome in categorized patients with primary myocardial inf...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-09-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-023-01035-9 |
| _version_ | 1797556524525027328 |
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| author | Yao Lu Jingjing Meng Mingkai Yun Marcus Hacker Xiang Li Xiaoli Zhang |
| author_facet | Yao Lu Jingjing Meng Mingkai Yun Marcus Hacker Xiang Li Xiaoli Zhang |
| author_sort | Yao Lu |
| collection | DOAJ |
| description | Abstract Background Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-inflammatory activation. We aimed to investigate the hematopoietic-inflammatory activation and the outcome in categorized patients with primary myocardial infarction (PMI) versus RMI as well as chronic stable angina (CSA) by 18F-FDG PET. Results A total of 105 patients (88 males; 60.1 ± 9.7 years) were included. Target-to-background ratio of bone marrow (TBRBM) was highest in the PMI group (n = 45), intermediate in the RMI group (n = 30), and lowest in the CSA group (n = 30) (P < 0.001). RMI group exhibited larger scar, significantly reduced left ventricular ejection fraction, and enlarged end systolic volume in comparison with the PMI and CSA groups, respectively (P < 0.05). Additionally, there was a significantly positive correlation between TBRBM and TBRaorta (P < 0.001). The cumulative major adverse cardiac events free survival of patients in the RMI group was lower than that in the PMI and CSA groups during a median follow-up of 16.6 months (P = 0.026). Conclusions RMI conferred relatively decreased hematopoietic-inflammatory activation compared with PMI. Patients with RMI presented subsequent enlarged myocardial scar, worsened cardiac dysfunction, aggravated remodeling, and worse outcomes than that in PMI patients. |
| first_indexed | 2024-03-10T17:03:05Z |
| format | Article |
| id | doaj.art-9f644ce84d5240eb9ead0958368f5b1f |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-03-10T17:03:05Z |
| publishDate | 2023-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-9f644ce84d5240eb9ead0958368f5b1f2023-11-20T10:53:33ZengSpringerOpenEJNMMI Research2191-219X2023-09-011311910.1186/s13550-023-01035-9Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarctionYao Lu0Jingjing Meng1Mingkai Yun2Marcus Hacker3Xiang Li4Xiaoli Zhang5Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical UniversityDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of ViennaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of ViennaDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Background Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-inflammatory activation. We aimed to investigate the hematopoietic-inflammatory activation and the outcome in categorized patients with primary myocardial infarction (PMI) versus RMI as well as chronic stable angina (CSA) by 18F-FDG PET. Results A total of 105 patients (88 males; 60.1 ± 9.7 years) were included. Target-to-background ratio of bone marrow (TBRBM) was highest in the PMI group (n = 45), intermediate in the RMI group (n = 30), and lowest in the CSA group (n = 30) (P < 0.001). RMI group exhibited larger scar, significantly reduced left ventricular ejection fraction, and enlarged end systolic volume in comparison with the PMI and CSA groups, respectively (P < 0.05). Additionally, there was a significantly positive correlation between TBRBM and TBRaorta (P < 0.001). The cumulative major adverse cardiac events free survival of patients in the RMI group was lower than that in the PMI and CSA groups during a median follow-up of 16.6 months (P = 0.026). Conclusions RMI conferred relatively decreased hematopoietic-inflammatory activation compared with PMI. Patients with RMI presented subsequent enlarged myocardial scar, worsened cardiac dysfunction, aggravated remodeling, and worse outcomes than that in PMI patients.https://doi.org/10.1186/s13550-023-01035-9Recurrent myocardial infarctionBone marrowHematopoiesisPositron emission tomography |
| spellingShingle | Yao Lu Jingjing Meng Mingkai Yun Marcus Hacker Xiang Li Xiaoli Zhang Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction EJNMMI Research Recurrent myocardial infarction Bone marrow Hematopoiesis Positron emission tomography |
| title | Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction |
| title_full | Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction |
| title_fullStr | Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction |
| title_full_unstemmed | Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction |
| title_short | Reduced hematopoietic-inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction |
| title_sort | reduced hematopoietic inflammatory response and worse outcomes in patients with recurrent myocardial infarction in comparison with primary myocardial infarction |
| topic | Recurrent myocardial infarction Bone marrow Hematopoiesis Positron emission tomography |
| url | https://doi.org/10.1186/s13550-023-01035-9 |
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