Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation

Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation

The human 2-oxoglutarate dehydrogenase complex (hOGDHc) is a key enzyme in the tricarboxylic acid cycle and is one of the main regulators of mitochondrial metabolism through NADH and reactive oxygen species levels. Evidence was obtained for formation of a hybrid complex between the hOGDHc and its ho...

Full description

Bibliographic Details
Main Authors: Oliver Ozohanics, Xu Zhang, Natalia S. Nemeria, Attila Ambrus, Frank Jordan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
2-oxoglutarate dehydrogenase
2-oxoadipate dehydrogenase
dihydrolipoyl succinyltransferase
protein–protein interactions
chemical cross-linking mass spectrometry
molecular dynamics simulations
Online Access:https://www.mdpi.com/1422-0067/24/5/4555

Internet

https://www.mdpi.com/1422-0067/24/5/4555

Similar Items