Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome
Peyman Izadpanah,1 Fatemeh Asadian,2 Ali Jangjou3 1Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3Emergency Medicine Department, Shiraz Unive...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/association-of-serum-renalase-levels-and-renalase-rs10887800-polymorph-peer-reviewed-article-DMSO |
| _version_ | 1828045810557779968 |
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| author | Izadpanah P Asadian F Jangjou A |
| author_facet | Izadpanah P Asadian F Jangjou A |
| author_sort | Izadpanah P |
| collection | DOAJ |
| description | Peyman Izadpanah,1 Fatemeh Asadian,2 Ali Jangjou3 1Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3Emergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranCorrespondence: Ali JangjouEmergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranTel +98-9173157555Email ali_jangjou@ymail.comPurpose: An increased risk of cardiovascular mortality and morbidity has been linked with metabolic syndrome (MetS), described as the secondary risk reduction target. These patients are predisposed to high complication levels such as unstable angina-pectoris (USAP) by MetS. As with the role of renalase in the regulation of blood pressure (BP), the study was carried out to determine the levels of renalase circulation in patients with USAP and MetS (USAP+MetS), as well as the association of renalase gene (RNLS) rs10887800 polymorphism and USAP and MetS susceptibility.Patients and Methods: A total of 134 patients with USAP+MetS and 134 control subjects were recruited in this case-control study.Results: Renalase was found to have a significantly higher level in USAP+MetS patients (23.28 ± 4.09 μg/dL) than in healthy ones (20.81 ± 2.73 μg/dL) (P < 0.001). Also, it was shown that renalase sensitivity and specificity values for the early diagnosis of USAP and MetS seemed to be 53.7% and 76.9, respectively. Moreover, the value for renalase area under curve (AUC) was 0.654 (95% CI: 0.58– 0.72). The frequency of rs10887800 AG and GG genotypes of RNLS gene was significantly higher in USAP+MetS patients than in control subjects, suggesting that this genotype might be a risk factor against USAP+MetS (OR = 2.114 [95% CI 1.113– 4.016]; P = 0.022) and (OR = 2.057 [95% CI 1.011– 4.186]; P = 0.047), respectively.Conclusion: The present results showed that renalase serum levels increased in USAP and MetS patients. Moreover, the RNLS rs10887800 was reported to be associated with a higher risk of USAP+MetS.Keywords: cardiovascular diseases, metabolic syndrome, polymorphism, renalase, rs10887800, unstable angina pectoris |
| first_indexed | 2024-04-10T18:17:08Z |
| format | Article |
| id | doaj.art-9f6668e371de42eabf5bcb8c21f319d1 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:17:08Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-9f6668e371de42eabf5bcb8c21f319d12023-02-02T08:31:43ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-09-01Volume 133249325957039Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic SyndromeIzadpanah PAsadian FJangjou APeyman Izadpanah,1 Fatemeh Asadian,2 Ali Jangjou3 1Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3Emergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranCorrespondence: Ali JangjouEmergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranTel +98-9173157555Email ali_jangjou@ymail.comPurpose: An increased risk of cardiovascular mortality and morbidity has been linked with metabolic syndrome (MetS), described as the secondary risk reduction target. These patients are predisposed to high complication levels such as unstable angina-pectoris (USAP) by MetS. As with the role of renalase in the regulation of blood pressure (BP), the study was carried out to determine the levels of renalase circulation in patients with USAP and MetS (USAP+MetS), as well as the association of renalase gene (RNLS) rs10887800 polymorphism and USAP and MetS susceptibility.Patients and Methods: A total of 134 patients with USAP+MetS and 134 control subjects were recruited in this case-control study.Results: Renalase was found to have a significantly higher level in USAP+MetS patients (23.28 ± 4.09 μg/dL) than in healthy ones (20.81 ± 2.73 μg/dL) (P < 0.001). Also, it was shown that renalase sensitivity and specificity values for the early diagnosis of USAP and MetS seemed to be 53.7% and 76.9, respectively. Moreover, the value for renalase area under curve (AUC) was 0.654 (95% CI: 0.58– 0.72). The frequency of rs10887800 AG and GG genotypes of RNLS gene was significantly higher in USAP+MetS patients than in control subjects, suggesting that this genotype might be a risk factor against USAP+MetS (OR = 2.114 [95% CI 1.113– 4.016]; P = 0.022) and (OR = 2.057 [95% CI 1.011– 4.186]; P = 0.047), respectively.Conclusion: The present results showed that renalase serum levels increased in USAP and MetS patients. Moreover, the RNLS rs10887800 was reported to be associated with a higher risk of USAP+MetS.Keywords: cardiovascular diseases, metabolic syndrome, polymorphism, renalase, rs10887800, unstable angina pectorishttps://www.dovepress.com/association-of-serum-renalase-levels-and-renalase-rs10887800-polymorph-peer-reviewed-article-DMSOcardiovascular diseasesmetabolic syndromepolymorphismrenalasers10887800unstable angina pectoris |
| spellingShingle | Izadpanah P Asadian F Jangjou A Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome Diabetes, Metabolic Syndrome and Obesity cardiovascular diseases metabolic syndrome polymorphism renalase rs10887800 unstable angina pectoris |
| title | Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome |
| title_full | Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome |
| title_fullStr | Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome |
| title_full_unstemmed | Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome |
| title_short | Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome |
| title_sort | association of serum renalase levels and renalase rs10887800 polymorphism with unstable angina pectoris patients having metabolic syndrome |
| topic | cardiovascular diseases metabolic syndrome polymorphism renalase rs10887800 unstable angina pectoris |
| url | https://www.dovepress.com/association-of-serum-renalase-levels-and-renalase-rs10887800-polymorph-peer-reviewed-article-DMSO |
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