Symposium 16: Clinical presentation. Diagnostic difficulties
Autoimmune diabetes is the type of DM characterized by autoimmune destruction of the beta cell by the cellular immune system in genetically predisposed people (mainly HLA polymorphisms) and with an environmental trigger that is generally not well known. From a clinical point of view, it has traditi...
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| Format: | Article |
| Language: | Spanish |
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Sello Editorial Lugones
2022-09-01
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| Series: | Revista de la Sociedad Argentina de Diabetes |
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| Online Access: | https://revistasad.com/index.php/diabetes/article/view/633 |
| _version_ | 1811309197521846272 |
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| author | Alejandro De Dios |
| author_facet | Alejandro De Dios |
| author_sort | Alejandro De Dios |
| collection | DOAJ |
| description | Autoimmune diabetes is the type of DM characterized by autoimmune destruction of the beta cell by the cellular immune system in genetically predisposed people (mainly HLA polymorphisms) and with an environmental trigger that is generally not well known.
From a clinical point of view, it has traditionally been considered a type of DM that begins in childhood and adolescence, with a high genetic predisposition, aggressive destruction of the beta cell mass, rapid fall in insulin secretion, and presentation in ketosis or ketoacidosis. However, immune-mediated DM in adults is currently the most frequent form of presentation of autoimmune DM (even more than in the childhood and youth stage). In this case, it does not behave as such a homogeneous group of presentation since, although some (the smallest percentage) may debut in ketoacidosis, the vast majority present with progressive hyperglycemia that in many circumstances can simulate forms of presentation of T2DM. This is because in these cases, not only is genetic predisposition linked to HLA polymorphisms, but also to other polymorphisms that determine beta cell secretion failure and even overweight/obesity can play a determining role in the pathophysiology of the disease. Immune-mediated DM in adults. |
| first_indexed | 2024-04-13T09:38:02Z |
| format | Article |
| id | doaj.art-9f672e0207984e4886367c14582f6be8 |
| institution | Directory Open Access Journal |
| issn | 0325-5247 2346-9420 |
| language | Spanish |
| last_indexed | 2024-04-13T09:38:02Z |
| publishDate | 2022-09-01 |
| publisher | Sello Editorial Lugones |
| record_format | Article |
| series | Revista de la Sociedad Argentina de Diabetes |
| spelling | doaj.art-9f672e0207984e4886367c14582f6be82022-12-22T02:52:02ZspaSello Editorial LugonesRevista de la Sociedad Argentina de Diabetes0325-52472346-94202022-09-01563Sup949410.47196/diab.v56i3Sup.633547Symposium 16: Clinical presentation. Diagnostic difficultiesAlejandro De Dios0Hospital de Clínicas Gral. José de San Martín, Ciudad Autónoma de Buenos Aires, ArgentinaAutoimmune diabetes is the type of DM characterized by autoimmune destruction of the beta cell by the cellular immune system in genetically predisposed people (mainly HLA polymorphisms) and with an environmental trigger that is generally not well known. From a clinical point of view, it has traditionally been considered a type of DM that begins in childhood and adolescence, with a high genetic predisposition, aggressive destruction of the beta cell mass, rapid fall in insulin secretion, and presentation in ketosis or ketoacidosis. However, immune-mediated DM in adults is currently the most frequent form of presentation of autoimmune DM (even more than in the childhood and youth stage). In this case, it does not behave as such a homogeneous group of presentation since, although some (the smallest percentage) may debut in ketoacidosis, the vast majority present with progressive hyperglycemia that in many circumstances can simulate forms of presentation of T2DM. This is because in these cases, not only is genetic predisposition linked to HLA polymorphisms, but also to other polymorphisms that determine beta cell secretion failure and even overweight/obesity can play a determining role in the pathophysiology of the disease. Immune-mediated DM in adults.https://revistasad.com/index.php/diabetes/article/view/633diabetes inmunomediada |
| spellingShingle | Alejandro De Dios Symposium 16: Clinical presentation. Diagnostic difficulties Revista de la Sociedad Argentina de Diabetes diabetes inmunomediada |
| title | Symposium 16: Clinical presentation. Diagnostic difficulties |
| title_full | Symposium 16: Clinical presentation. Diagnostic difficulties |
| title_fullStr | Symposium 16: Clinical presentation. Diagnostic difficulties |
| title_full_unstemmed | Symposium 16: Clinical presentation. Diagnostic difficulties |
| title_short | Symposium 16: Clinical presentation. Diagnostic difficulties |
| title_sort | symposium 16 clinical presentation diagnostic difficulties |
| topic | diabetes inmunomediada |
| url | https://revistasad.com/index.php/diabetes/article/view/633 |
| work_keys_str_mv | AT alejandrodedios symposium16clinicalpresentationdiagnosticdifficulties |