Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis
Background: Several studies indicate, particularly in the case of [18F]PSMA-1007, a relatively high rate of detection of ganglia in PSMA PET imaging. Ganglia are an integral part of the sympathetic portion of the autonomous nervous system. To date, no studies have directly compared [68Ga]Ga-PSMA-11...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/10/2787 |
| _version_ | 1797600722622087168 |
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| author | Emil Novruzov Dominik Schmitt Katalin Mattes-György Markus Beu Yuriko Mori Mardjan Dabir Jan Philipp Radtke Günter Niegisch Peter Albers Lars Schimmöller Gerald Antoch Christina Antke Frederik L. Giesel Eduards Mamlins |
| author_facet | Emil Novruzov Dominik Schmitt Katalin Mattes-György Markus Beu Yuriko Mori Mardjan Dabir Jan Philipp Radtke Günter Niegisch Peter Albers Lars Schimmöller Gerald Antoch Christina Antke Frederik L. Giesel Eduards Mamlins |
| author_sort | Emil Novruzov |
| collection | DOAJ |
| description | Background: Several studies indicate, particularly in the case of [18F]PSMA-1007, a relatively high rate of detection of ganglia in PSMA PET imaging. Ganglia are an integral part of the sympathetic portion of the autonomous nervous system. To date, no studies have directly compared [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 ganglionic uptake intra-individually and analyzed the underlying molecular and physical mechanisms of different detection rates. With this monocentric retrospective study, we sought to evaluate the intra-individual physiological ganglion uptake of these different PSMA ligands in evidence-based imaging for prostate cancer. Methods: Our cohort consists of 19 male patients (median age 72 ± 9 with a range of 56–85) with biochemical recurrence of prostate cancer who underwent both [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 PET/CT in our clinic on the same scanner per standard care between March 2015 and March 2022. Tracer uptake was quantified according to maximum standardized uptake value (SUV<sub>max</sub>) for both [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 PET/CT scans. Ganglia-to-background ratios (GBRs) were determined to quantify the image contrast through dividing the SUV<sub>max</sub> of the ganglia by the background value (SUV<sub>max</sub> of blood pool in the descending aorta, fatty tissue, and skeletal muscle in gluteal region). We used descriptive analyses for demographics and tumor characteristics and performed two-way repeated-measures ANOVA (analysis of variance) for SUV metrics including GBR measurements. Results: In total, we examined 101 ganglia with [<sup>18</sup>F]PSMA-1007 scanning, localized mostly in pairs as stellate, coeliac, and sacral, of which 76 were also detected with [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT scanning. There was no statistically significant difference in PSMA uptake in terms of SUV<sub>max</sub> between [<sup>18</sup>F]PSMA-1007 and [<sup>68</sup>Ga]Ga-PSMA-11 (<i>p</i> value: 0.052). In contrast, the comparison of GBRs revealed a higher detectability rate of ganglia with [<sup>18</sup>F]PSMA-1007 imaging (<i>p</i> < 0.001). Furthermore, a separate comparison of ganglia with respect to their anatomical location also demonstrated statistically significant differences both within and between [<sup>18</sup>F]PSMA-1007 and [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT scans. Conclusion: Given the impression of more accentuated [<sup>18</sup>F]PSMA-1007 uptake in ganglia compared with <sup>68</sup>Ga-labelled counterparts, our study demonstrated that the better detectability of ganglia is not due to more intense [<sup>18</sup>F]PSMA-1007 uptake by these small structures but to much more favorable physical properties of the radionuclide <sup>18</sup>F. The most relevant limitations of our study are its retrospective design and the small patient cohort. |
| first_indexed | 2024-03-11T03:51:55Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T03:51:55Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9f6b3eb2a8334bf98f2f5a9a8a4632c32023-11-18T00:48:58ZengMDPI AGCancers2072-66942023-05-011510278710.3390/cancers15102787Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric AnalysisEmil Novruzov0Dominik Schmitt1Katalin Mattes-György2Markus Beu3Yuriko Mori4Mardjan Dabir5Jan Philipp Radtke6Günter Niegisch7Peter Albers8Lars Schimmöller9Gerald Antoch10Christina Antke11Frederik L. Giesel12Eduards Mamlins13Department of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Urology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Urology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Urology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, GermanyBackground: Several studies indicate, particularly in the case of [18F]PSMA-1007, a relatively high rate of detection of ganglia in PSMA PET imaging. Ganglia are an integral part of the sympathetic portion of the autonomous nervous system. To date, no studies have directly compared [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 ganglionic uptake intra-individually and analyzed the underlying molecular and physical mechanisms of different detection rates. With this monocentric retrospective study, we sought to evaluate the intra-individual physiological ganglion uptake of these different PSMA ligands in evidence-based imaging for prostate cancer. Methods: Our cohort consists of 19 male patients (median age 72 ± 9 with a range of 56–85) with biochemical recurrence of prostate cancer who underwent both [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 PET/CT in our clinic on the same scanner per standard care between March 2015 and March 2022. Tracer uptake was quantified according to maximum standardized uptake value (SUV<sub>max</sub>) for both [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 PET/CT scans. Ganglia-to-background ratios (GBRs) were determined to quantify the image contrast through dividing the SUV<sub>max</sub> of the ganglia by the background value (SUV<sub>max</sub> of blood pool in the descending aorta, fatty tissue, and skeletal muscle in gluteal region). We used descriptive analyses for demographics and tumor characteristics and performed two-way repeated-measures ANOVA (analysis of variance) for SUV metrics including GBR measurements. Results: In total, we examined 101 ganglia with [<sup>18</sup>F]PSMA-1007 scanning, localized mostly in pairs as stellate, coeliac, and sacral, of which 76 were also detected with [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT scanning. There was no statistically significant difference in PSMA uptake in terms of SUV<sub>max</sub> between [<sup>18</sup>F]PSMA-1007 and [<sup>68</sup>Ga]Ga-PSMA-11 (<i>p</i> value: 0.052). In contrast, the comparison of GBRs revealed a higher detectability rate of ganglia with [<sup>18</sup>F]PSMA-1007 imaging (<i>p</i> < 0.001). Furthermore, a separate comparison of ganglia with respect to their anatomical location also demonstrated statistically significant differences both within and between [<sup>18</sup>F]PSMA-1007 and [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT scans. Conclusion: Given the impression of more accentuated [<sup>18</sup>F]PSMA-1007 uptake in ganglia compared with <sup>68</sup>Ga-labelled counterparts, our study demonstrated that the better detectability of ganglia is not due to more intense [<sup>18</sup>F]PSMA-1007 uptake by these small structures but to much more favorable physical properties of the radionuclide <sup>18</sup>F. The most relevant limitations of our study are its retrospective design and the small patient cohort.https://www.mdpi.com/2072-6694/15/10/2787PSMA uptakeganglionganglia[<sup>18</sup>F]PSMA-1007[<sup>68</sup>Ga]Ga-PSMA-11PET |
| spellingShingle | Emil Novruzov Dominik Schmitt Katalin Mattes-György Markus Beu Yuriko Mori Mardjan Dabir Jan Philipp Radtke Günter Niegisch Peter Albers Lars Schimmöller Gerald Antoch Christina Antke Frederik L. Giesel Eduards Mamlins Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis Cancers PSMA uptake ganglion ganglia [<sup>18</sup>F]PSMA-1007 [<sup>68</sup>Ga]Ga-PSMA-11 PET |
| title | Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis |
| title_full | Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis |
| title_fullStr | Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis |
| title_full_unstemmed | Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis |
| title_short | Intra-Individual Comparison of Physiologic [<sup>68</sup>Ga]Ga-PSMA-11 and [<sup>18</sup>F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: A Retrospective, Monocentric Analysis |
| title_sort | intra individual comparison of physiologic sup 68 sup ga ga psma 11 and sup 18 sup f psma 1007 uptake in ganglia in patients with prostate cancer a retrospective monocentric analysis |
| topic | PSMA uptake ganglion ganglia [<sup>18</sup>F]PSMA-1007 [<sup>68</sup>Ga]Ga-PSMA-11 PET |
| url | https://www.mdpi.com/2072-6694/15/10/2787 |
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