Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this t...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2017-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/23/10/17-0834_article |
| _version_ | 1818979462258098176 |
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| author | Andrey Maryandyshev Emanuele Pontali Simon Tiberi Onno Akkerman Shashank Ganatra Tsetan Dorji Sadutshang Jan-Willem Alffenaar Rohit Amale Jai Mullerpattan Sonam Topgyal Zarir Farokh Udwadia Rosella Centis Lia D’Ambrosio Giovanni Sotgiu Giovanni Battista Migliori |
| author_facet | Andrey Maryandyshev Emanuele Pontali Simon Tiberi Onno Akkerman Shashank Ganatra Tsetan Dorji Sadutshang Jan-Willem Alffenaar Rohit Amale Jai Mullerpattan Sonam Topgyal Zarir Farokh Udwadia Rosella Centis Lia D’Ambrosio Giovanni Sotgiu Giovanni Battista Migliori |
| author_sort | Andrey Maryandyshev |
| collection | DOAJ |
| description | We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options. |
| first_indexed | 2024-12-20T16:59:55Z |
| format | Article |
| id | doaj.art-9f6c72ec93884d30a3be4f41e4120837 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-20T16:59:55Z |
| publishDate | 2017-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-9f6c72ec93884d30a3be4f41e41208372022-12-21T19:32:35ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592017-10-0123101718172110.3201/eid2310.170834Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant TuberculosisAndrey MaryandyshevEmanuele PontaliSimon TiberiOnno AkkermanShashank GanatraTsetan Dorji SadutshangJan-Willem AlffenaarRohit AmaleJai MullerpattanSonam TopgyalZarir Farokh UdwadiaRosella CentisLia D’AmbrosioGiovanni SotgiuGiovanni Battista MiglioriWe report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.https://wwwnc.cdc.gov/eid/article/23/10/17-0834_articleMDR-TBXDR-TBbedaquilinedelamanidcombination treatmenteffectiveness |
| spellingShingle | Andrey Maryandyshev Emanuele Pontali Simon Tiberi Onno Akkerman Shashank Ganatra Tsetan Dorji Sadutshang Jan-Willem Alffenaar Rohit Amale Jai Mullerpattan Sonam Topgyal Zarir Farokh Udwadia Rosella Centis Lia D’Ambrosio Giovanni Sotgiu Giovanni Battista Migliori Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis Emerging Infectious Diseases MDR-TB XDR-TB bedaquiline delamanid combination treatment effectiveness |
| title | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_full | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_fullStr | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_full_unstemmed | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_short | Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis |
| title_sort | bedaquiline and delamanid combination treatment of 5 patients with pulmonary extensively drug resistant tuberculosis |
| topic | MDR-TB XDR-TB bedaquiline delamanid combination treatment effectiveness |
| url | https://wwwnc.cdc.gov/eid/article/23/10/17-0834_article |
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