Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status
Bay leaf (<i>Laurus nobilis</i> L.) has been shown to possesses various biological activities such as wound healing activity, antioxidant activity, antibacterial activity, antiviral activity, immunostimulant activity, anticholinergic activity, antifungal activity, insect repellant activi...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/2/259 |
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| author | Ion Brinza Razvan Stefan Boiangiu Monica Hancianu Oana Cioanca Ilkay Erdogan Orhan Lucian Hritcu |
| author_facet | Ion Brinza Razvan Stefan Boiangiu Monica Hancianu Oana Cioanca Ilkay Erdogan Orhan Lucian Hritcu |
| author_sort | Ion Brinza |
| collection | DOAJ |
| description | Bay leaf (<i>Laurus nobilis</i> L.) has been shown to possesses various biological activities such as wound healing activity, antioxidant activity, antibacterial activity, antiviral activity, immunostimulant activity, anticholinergic activity, antifungal activity, insect repellant activity, anticonvulsant activity, antimutagenic activity, and analgesic and anti-inflammatory activity. The present study aimed to investigate whether the bay leaf incense (BL) elicits the memory formation via the action on the cholinergic system using a scopolamine (Sco)-induced rat model. Rats were exposed to BL over 5 min in a smoking chamber apparatus once daily for 22 days, whereas memory impairment was induced by Sco (0.7 mg/kg), a muscarinic receptor antagonist, delivered 30 min before each behavioral test. The phytochemical composition of BL was achieved by gas chromatograph–mass spectrometry (GCMS). Behavioral effects in rats were assessed by Y-maze, radial arm maze (RAM), and novel object recognition (NOR) paradigms. Additionally, the acetylcholinesterase (AChE) activity and the oxidative stress markers in the rat hippocampus were also evaluated. Exposure to BL significantly ameliorated Sco-induced cognitive impairment and oxidative stress in the rat hippocampus. The obtained results suggested that BL-induced ameliorative cognitive effects are mediated by enhancement of the cholinergic system and antioxidant activities. |
| first_indexed | 2024-03-09T05:10:17Z |
| format | Article |
| id | doaj.art-9f6d754a370f4793854e7003ebe322a7 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T05:10:17Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-9f6d754a370f4793854e7003ebe322a72023-12-03T12:50:49ZengMDPI AGAntioxidants2076-39212021-02-0110225910.3390/antiox10020259Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant StatusIon Brinza0Razvan Stefan Boiangiu1Monica Hancianu2Oana Cioanca3Ilkay Erdogan Orhan4Lucian Hritcu5Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, RomaniaDepartment of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, TurkeyDepartment of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, RomaniaBay leaf (<i>Laurus nobilis</i> L.) has been shown to possesses various biological activities such as wound healing activity, antioxidant activity, antibacterial activity, antiviral activity, immunostimulant activity, anticholinergic activity, antifungal activity, insect repellant activity, anticonvulsant activity, antimutagenic activity, and analgesic and anti-inflammatory activity. The present study aimed to investigate whether the bay leaf incense (BL) elicits the memory formation via the action on the cholinergic system using a scopolamine (Sco)-induced rat model. Rats were exposed to BL over 5 min in a smoking chamber apparatus once daily for 22 days, whereas memory impairment was induced by Sco (0.7 mg/kg), a muscarinic receptor antagonist, delivered 30 min before each behavioral test. The phytochemical composition of BL was achieved by gas chromatograph–mass spectrometry (GCMS). Behavioral effects in rats were assessed by Y-maze, radial arm maze (RAM), and novel object recognition (NOR) paradigms. Additionally, the acetylcholinesterase (AChE) activity and the oxidative stress markers in the rat hippocampus were also evaluated. Exposure to BL significantly ameliorated Sco-induced cognitive impairment and oxidative stress in the rat hippocampus. The obtained results suggested that BL-induced ameliorative cognitive effects are mediated by enhancement of the cholinergic system and antioxidant activities.https://www.mdpi.com/2076-3921/10/2/259<i>Laurus nobilis</i>bay leafincensescopolaminecholinergic systemmemory |
| spellingShingle | Ion Brinza Razvan Stefan Boiangiu Monica Hancianu Oana Cioanca Ilkay Erdogan Orhan Lucian Hritcu Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status Antioxidants <i>Laurus nobilis</i> bay leaf incense scopolamine cholinergic system memory |
| title | Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status |
| title_full | Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status |
| title_fullStr | Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status |
| title_full_unstemmed | Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status |
| title_short | Bay Leaf (<i>Laurus Nobilis</i> L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status |
| title_sort | bay leaf i laurus nobilis i l incense improved scopolamine induced amnesic rats by restoring cholinergic dysfunction and brain antioxidant status |
| topic | <i>Laurus nobilis</i> bay leaf incense scopolamine cholinergic system memory |
| url | https://www.mdpi.com/2076-3921/10/2/259 |
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