Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming
Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is also characterized by impaired blood flow through the utero-placental circulation and relative placental ischemia, whic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00134/full |
| _version_ | 1818496008110211072 |
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| author | Carlos Alonso Escudero James M Roberts Leslie eMyatt Igor eFeoktistov |
| author_facet | Carlos Alonso Escudero James M Roberts Leslie eMyatt Igor eFeoktistov |
| author_sort | Carlos Alonso Escudero |
| collection | DOAJ |
| description | Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is also characterized by impaired blood flow through the utero-placental circulation and relative placental ischemia, which in turn, may generate feto-placental endothelial dysfunction. Endothelial dysfunction in offspring born from preeclamptic pregnancies has been associated with an increased risk of cardiovascular disease, including hypertension, later in life. Interestingly, diminished endothelial function, manifested by low angiogenic capacity, leads to hypertension in animal studies. Recently, we have shown that the adenosine receptor A2A/nitric oxide/vascular endothelial growth factor axis is reduced in human umbilical vein endothelial cells derived from preeclamptic pregnancies, an effect correlated with gestational age at onset of preeclampsia. We and others suggested that impaired vascular function might be associated with high cardiovascular risk in offspring exposed to pregnancy diseases. However, we are not aware of any studies that examine impaired adenosine-mediated angiogenesis as a possible link to hypertension in offspring born from preeclamptic pregnancies. In this review, we present evidence supporting the hypothesis that reduced adenosine-mediated angiogenesis during preeclamptic pregnancies might be associated with development of hypertension in the offspring. |
| first_indexed | 2024-12-10T18:27:48Z |
| format | Article |
| id | doaj.art-9f6e1cbf270c4f6cb65616aa859b3629 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T18:27:48Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-9f6e1cbf270c4f6cb65616aa859b36292022-12-22T01:38:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122014-06-01510.3389/fphar.2014.0013489794Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programmingCarlos Alonso Escudero0James M Roberts1Leslie eMyatt2Igor eFeoktistov3Universidad del Bío-BíoMagee Women Research InstituteUniversity of Texas Health Science Center San AntonioVanderbilt UniversityPreeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is also characterized by impaired blood flow through the utero-placental circulation and relative placental ischemia, which in turn, may generate feto-placental endothelial dysfunction. Endothelial dysfunction in offspring born from preeclamptic pregnancies has been associated with an increased risk of cardiovascular disease, including hypertension, later in life. Interestingly, diminished endothelial function, manifested by low angiogenic capacity, leads to hypertension in animal studies. Recently, we have shown that the adenosine receptor A2A/nitric oxide/vascular endothelial growth factor axis is reduced in human umbilical vein endothelial cells derived from preeclamptic pregnancies, an effect correlated with gestational age at onset of preeclampsia. We and others suggested that impaired vascular function might be associated with high cardiovascular risk in offspring exposed to pregnancy diseases. However, we are not aware of any studies that examine impaired adenosine-mediated angiogenesis as a possible link to hypertension in offspring born from preeclamptic pregnancies. In this review, we present evidence supporting the hypothesis that reduced adenosine-mediated angiogenesis during preeclamptic pregnancies might be associated with development of hypertension in the offspring.http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00134/fullPlacentaPre-EclampsiaAngiogenesisprogrammingadenosine receptors |
| spellingShingle | Carlos Alonso Escudero James M Roberts Leslie eMyatt Igor eFeoktistov Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming Frontiers in Pharmacology Placenta Pre-Eclampsia Angiogenesis programming adenosine receptors |
| title | Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming |
| title_full | Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming |
| title_fullStr | Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming |
| title_full_unstemmed | Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming |
| title_short | Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming |
| title_sort | impaired adenosine mediated angiogenesis in preeclampsia potential implications for fetal programming |
| topic | Placenta Pre-Eclampsia Angiogenesis programming adenosine receptors |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00134/full |
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