Small extracellular vesicles‐based cell‐free strategies for therapy
Abstract Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellular messenger regulating recipient cell function and play a role in disease initiation and...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-03-01
|
| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.57 |
| _version_ | 1818879278750629888 |
|---|---|
| author | Yeye Guo Huaishan Wang Lili Huang Lingling Ou Jinjin Zhu Shujing Liu Xiaowei Xu |
| author_facet | Yeye Guo Huaishan Wang Lili Huang Lingling Ou Jinjin Zhu Shujing Liu Xiaowei Xu |
| author_sort | Yeye Guo |
| collection | DOAJ |
| description | Abstract Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellular messenger regulating recipient cell function and play a role in disease initiation and progression. sEVs derived from certain cells, such as mesenchymal stem cells and immune cells, have the potential for clinical therapy as they possess the characteristics of their parental cells. With better understanding of sEVs biogenesis, their transportation properties, extended circulatory capability, and exceptional biocompatibility, sEVs emerge as a potential therapeutic tool in the clinic. Here, we summarize applications of sEVs‐based therapies in different diseases and current knowledge about the strategies in bioengineered sEVs, as well as the challenges for their use in clinical settings. |
| first_indexed | 2024-12-19T14:27:32Z |
| format | Article |
| id | doaj.art-9f728e75a3fd4693825bffdc587c9758 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-12-19T14:27:32Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-9f728e75a3fd4693825bffdc587c97582022-12-21T20:17:35ZengWileyMedComm2688-26632021-03-0121172610.1002/mco2.57Small extracellular vesicles‐based cell‐free strategies for therapyYeye Guo0Huaishan Wang1Lili Huang2Lingling Ou3Jinjin Zhu4Shujing Liu5Xiaowei Xu6Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USAAbstract Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellular messenger regulating recipient cell function and play a role in disease initiation and progression. sEVs derived from certain cells, such as mesenchymal stem cells and immune cells, have the potential for clinical therapy as they possess the characteristics of their parental cells. With better understanding of sEVs biogenesis, their transportation properties, extended circulatory capability, and exceptional biocompatibility, sEVs emerge as a potential therapeutic tool in the clinic. Here, we summarize applications of sEVs‐based therapies in different diseases and current knowledge about the strategies in bioengineered sEVs, as well as the challenges for their use in clinical settings.https://doi.org/10.1002/mco2.57cancerexosomeextracellular vesicleimmunotherapy |
| spellingShingle | Yeye Guo Huaishan Wang Lili Huang Lingling Ou Jinjin Zhu Shujing Liu Xiaowei Xu Small extracellular vesicles‐based cell‐free strategies for therapy MedComm cancer exosome extracellular vesicle immunotherapy |
| title | Small extracellular vesicles‐based cell‐free strategies for therapy |
| title_full | Small extracellular vesicles‐based cell‐free strategies for therapy |
| title_fullStr | Small extracellular vesicles‐based cell‐free strategies for therapy |
| title_full_unstemmed | Small extracellular vesicles‐based cell‐free strategies for therapy |
| title_short | Small extracellular vesicles‐based cell‐free strategies for therapy |
| title_sort | small extracellular vesicles based cell free strategies for therapy |
| topic | cancer exosome extracellular vesicle immunotherapy |
| url | https://doi.org/10.1002/mco2.57 |
| work_keys_str_mv | AT yeyeguo smallextracellularvesiclesbasedcellfreestrategiesfortherapy AT huaishanwang smallextracellularvesiclesbasedcellfreestrategiesfortherapy AT lilihuang smallextracellularvesiclesbasedcellfreestrategiesfortherapy AT linglingou smallextracellularvesiclesbasedcellfreestrategiesfortherapy AT jinjinzhu smallextracellularvesiclesbasedcellfreestrategiesfortherapy AT shujingliu smallextracellularvesiclesbasedcellfreestrategiesfortherapy AT xiaoweixu smallextracellularvesiclesbasedcellfreestrategiesfortherapy |