Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation
Summary: Background/Objective: The neutrophil-to-lymphocyte ratio (NLR) is a simple index that represents systemic inflammatory change. The number of platelets is also known to reflect both post-transplant graft regeneration and dysfunction. Thus, we aimed to investigate the usefulness of NLR and p...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-07-01
|
| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958416304973 |
| _version_ | 1811232399580725248 |
|---|---|
| author | Hironori Hayashi Hiroyuki Takamura Yoshinao Ohbatake Shinichi Nakanuma Hidehiro Tajima Sachio Fushida Ichiro Onishi Takashi Tani Koichi Shimizu Tetsuo Ohta |
| author_facet | Hironori Hayashi Hiroyuki Takamura Yoshinao Ohbatake Shinichi Nakanuma Hidehiro Tajima Sachio Fushida Ichiro Onishi Takashi Tani Koichi Shimizu Tetsuo Ohta |
| author_sort | Hironori Hayashi |
| collection | DOAJ |
| description | Summary: Background/Objective: The neutrophil-to-lymphocyte ratio (NLR) is a simple index that represents systemic inflammatory change. The number of platelets is also known to reflect both post-transplant graft regeneration and dysfunction. Thus, we aimed to investigate the usefulness of NLR and platelet number in predicting the clinical course after adult-to-adult living donor liver transplantation (AA-LDLT) in the acute postoperative period in recipients. Methods: Between January 1999 and December 2013, 61 patients underwent their first AA-LDLT at our institute. We retrospectively analyzed their clinical data, including NLR and number of platelets, until postoperative day 14, and evaluated their ability to predict prognosis after AA-LDLT. Results: The optimal cutoff values of postoperative maximum NLR and maximum platelets to predict prognosis were 50 and 80 × 103/μL, respectively. The 1- and 5-year survival rates were 87.5% and 79.1% in the normal maximum NLR group, respectively, and 46.2% for both in the high maximum NLR group (p = 0.0033). The 1- and 5-year survival rates, respectively, were 90.9% and 84.1% in the high maximum platelets group and 47.1% and 41.2% in the low maximum platelets group (p < 0.0001). In multivariate analysis, maximum NLR ≥ 50 and maximum platelets < 80 × 103/μL were independently associated with 1-year mortality. Conclusion: A high NLR and a low platelet count during acute postoperative period might correlate with poor prognosis after AA-LDLT. Keywords: complete blood count, neutropenia, postoperative complications, thrombocytopenia |
| first_indexed | 2024-04-12T11:02:33Z |
| format | Article |
| id | doaj.art-9f752eae914d4a24a334186f721857c8 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-04-12T11:02:33Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-9f752eae914d4a24a334186f721857c82022-12-22T03:35:53ZengElsevierAsian Journal of Surgery1015-95842018-07-01414341348Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantationHironori Hayashi0Hiroyuki Takamura1Yoshinao Ohbatake2Shinichi Nakanuma3Hidehiro Tajima4Sachio Fushida5Ichiro Onishi6Takashi Tani7Koichi Shimizu8Tetsuo Ohta9Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan; Corresponding author. Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan.Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Surgery, National Hospital Organization Kanazawa Medical Center, 1-1 Shimoishibiki-machi, Kanazawa, Ishikawa 920-8650, JapanDepartment of Surgery, Public Central Hospital of Matto Ishikawa, 3-8 Kuramitsu, Hakusan, Ishikawa 924-0865, JapanDepartment of Surgery, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama, Toyama 930-8550, JapanDepartment of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanSummary: Background/Objective: The neutrophil-to-lymphocyte ratio (NLR) is a simple index that represents systemic inflammatory change. The number of platelets is also known to reflect both post-transplant graft regeneration and dysfunction. Thus, we aimed to investigate the usefulness of NLR and platelet number in predicting the clinical course after adult-to-adult living donor liver transplantation (AA-LDLT) in the acute postoperative period in recipients. Methods: Between January 1999 and December 2013, 61 patients underwent their first AA-LDLT at our institute. We retrospectively analyzed their clinical data, including NLR and number of platelets, until postoperative day 14, and evaluated their ability to predict prognosis after AA-LDLT. Results: The optimal cutoff values of postoperative maximum NLR and maximum platelets to predict prognosis were 50 and 80 × 103/μL, respectively. The 1- and 5-year survival rates were 87.5% and 79.1% in the normal maximum NLR group, respectively, and 46.2% for both in the high maximum NLR group (p = 0.0033). The 1- and 5-year survival rates, respectively, were 90.9% and 84.1% in the high maximum platelets group and 47.1% and 41.2% in the low maximum platelets group (p < 0.0001). In multivariate analysis, maximum NLR ≥ 50 and maximum platelets < 80 × 103/μL were independently associated with 1-year mortality. Conclusion: A high NLR and a low platelet count during acute postoperative period might correlate with poor prognosis after AA-LDLT. Keywords: complete blood count, neutropenia, postoperative complications, thrombocytopeniahttp://www.sciencedirect.com/science/article/pii/S1015958416304973 |
| spellingShingle | Hironori Hayashi Hiroyuki Takamura Yoshinao Ohbatake Shinichi Nakanuma Hidehiro Tajima Sachio Fushida Ichiro Onishi Takashi Tani Koichi Shimizu Tetsuo Ohta Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation Asian Journal of Surgery |
| title | Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation |
| title_full | Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation |
| title_fullStr | Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation |
| title_full_unstemmed | Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation |
| title_short | Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: A simple prognostic predictor for adult-to-adult living donor liver transplantation |
| title_sort | postoperative changes in neutrophil to lymphocyte ratio and platelet count a simple prognostic predictor for adult to adult living donor liver transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S1015958416304973 |
| work_keys_str_mv | AT hironorihayashi postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT hiroyukitakamura postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT yoshinaoohbatake postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT shinichinakanuma postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT hidehirotajima postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT sachiofushida postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT ichiroonishi postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT takashitani postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT koichishimizu postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation AT tetsuoohta postoperativechangesinneutrophiltolymphocyteratioandplateletcountasimpleprognosticpredictorforadulttoadultlivingdonorlivertransplantation |