Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways
Per- and polyfluoroalkyl substances (PFASs) and perfluoroalkyl ether carboxylic acids (PFECAs) are organic chemicals that are widely used in the manufacture of a wide range of human-made products. Many monitoring findings revealed the presence of PFASs and PFECAs in numerous environmental sources, i...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323005055 |
| _version_ | 1797812816014475264 |
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| author | Hee Joon Yoo Min Cheol Pyo Kyu Hyun Rhee Jae-Min Lim Seon-Ah Yang Min Ki Yoo Kwang-Won Lee |
| author_facet | Hee Joon Yoo Min Cheol Pyo Kyu Hyun Rhee Jae-Min Lim Seon-Ah Yang Min Ki Yoo Kwang-Won Lee |
| author_sort | Hee Joon Yoo |
| collection | DOAJ |
| description | Per- and polyfluoroalkyl substances (PFASs) and perfluoroalkyl ether carboxylic acids (PFECAs) are organic chemicals that are widely used in the manufacture of a wide range of human-made products. Many monitoring findings revealed the presence of PFASs and PFECAs in numerous environmental sources, including water, soil, and air, which drew more attention to both chemicals. Because of their unknown toxicity, the discovery of PFASs and PFECAs in a variety of environmental sources was viewed as a cause for concern. In the present study, male mice were given orally one of the typical PFASs, perfluorooctanoic acid (PFOA), and one of the representative PFECAs, hexafluoropropylene oxide-dimer acid (HFPO-DA). The liver index showing hepatomegaly rose significantly after 90 d of exposure to PFOA and HFPO-DA, respectively. While sharing similar suppressor genes, both chemicals demonstrated unique hepatotoxic mechanisms. In different ways, these two substances altered the expression of hepatic stress-sensing genes as well as the regulation of nuclear receptors. Not only are bile acid metabolism-related genes in the liver altered, but cholesterol metabolism-related genes as well. These results indicate that PFOA and HFPO-DA both cause hepatotoxicity and bile acid metabolism impairment with distinct mechanisms. |
| first_indexed | 2024-03-13T07:43:59Z |
| format | Article |
| id | doaj.art-9f76d84da4b042d1aa0a8513353d3632 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-13T07:43:59Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-9f76d84da4b042d1aa0a8513353d36322023-06-03T04:21:24ZengElsevierEcotoxicology and Environmental Safety0147-65132023-07-01259115001Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathwaysHee Joon Yoo0Min Cheol Pyo1Kyu Hyun Rhee2Jae-Min Lim3Seon-Ah Yang4Min Ki Yoo5Kwang-Won Lee6Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of Korea; Department of Food Bioscience and Technology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of Korea; Corresponding author at: Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Republic of Korea.Per- and polyfluoroalkyl substances (PFASs) and perfluoroalkyl ether carboxylic acids (PFECAs) are organic chemicals that are widely used in the manufacture of a wide range of human-made products. Many monitoring findings revealed the presence of PFASs and PFECAs in numerous environmental sources, including water, soil, and air, which drew more attention to both chemicals. Because of their unknown toxicity, the discovery of PFASs and PFECAs in a variety of environmental sources was viewed as a cause for concern. In the present study, male mice were given orally one of the typical PFASs, perfluorooctanoic acid (PFOA), and one of the representative PFECAs, hexafluoropropylene oxide-dimer acid (HFPO-DA). The liver index showing hepatomegaly rose significantly after 90 d of exposure to PFOA and HFPO-DA, respectively. While sharing similar suppressor genes, both chemicals demonstrated unique hepatotoxic mechanisms. In different ways, these two substances altered the expression of hepatic stress-sensing genes as well as the regulation of nuclear receptors. Not only are bile acid metabolism-related genes in the liver altered, but cholesterol metabolism-related genes as well. These results indicate that PFOA and HFPO-DA both cause hepatotoxicity and bile acid metabolism impairment with distinct mechanisms.http://www.sciencedirect.com/science/article/pii/S0147651323005055Per- and polyfluoroalkyl substancePerfluorooctanoic acidPFOAHexafluoropropylene oxide-dimer acidGenXHepatotoxicity |
| spellingShingle | Hee Joon Yoo Min Cheol Pyo Kyu Hyun Rhee Jae-Min Lim Seon-Ah Yang Min Ki Yoo Kwang-Won Lee Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways Ecotoxicology and Environmental Safety Per- and polyfluoroalkyl substance Perfluorooctanoic acid PFOA Hexafluoropropylene oxide-dimer acid GenX Hepatotoxicity |
| title | Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways |
| title_full | Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways |
| title_fullStr | Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways |
| title_full_unstemmed | Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways |
| title_short | Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways |
| title_sort | perfluorooctanoic acid pfoa and hexafluoropropylene oxide dimer acid genx hepatic stress and bile acid metabolism with different pathways |
| topic | Per- and polyfluoroalkyl substance Perfluorooctanoic acid PFOA Hexafluoropropylene oxide-dimer acid GenX Hepatotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323005055 |
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