P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment
Gliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals and immunomodulatory pathways, which increase the tumor’s aggressiveness. In response to hypoxia and glioma therapy, the am...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/20/6146 |
| _version_ | 1797513703718912000 |
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| author | Fernanda Bueno Morrone Pedro Vargas Liliana Rockenbach Thamiris Becker Scheffel |
| author_facet | Fernanda Bueno Morrone Pedro Vargas Liliana Rockenbach Thamiris Becker Scheffel |
| author_sort | Fernanda Bueno Morrone |
| collection | DOAJ |
| description | Gliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals and immunomodulatory pathways, which increase the tumor’s aggressiveness. In response to hypoxia and glioma therapy, the amounts of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) strongly increase in the extracellular space, and the purinergic signaling is triggered by nucleotides’ interaction in P2 receptors. Several cell types are present in the tumor microenvironment and can facilitate tumor growth. In fact, tumor cells can activate platelets by the ADP-P2Y<sub>12</sub> engagement, which plays an essential role in the cancer context, protecting tumors from the immune attack and providing molecules that contribute to the growth and maintenance of a rich environment to sustain the protumor cycle. Besides platelets, the P2Y<sub>12</sub> receptor is expressed by some tumors, such as renal carcinoma, colon carcinoma, and gliomas, being related to tumor progression. In this context, this review aims to depict the glioma microenvironment, focusing on the relationship between platelets and tumor malignancy. |
| first_indexed | 2024-03-10T06:21:17Z |
| format | Article |
| id | doaj.art-9f798d62b3cf422a8047a5fadc2dfe97 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:21:17Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9f798d62b3cf422a8047a5fadc2dfe972023-11-22T19:18:45ZengMDPI AGMolecules1420-30492021-10-012620614610.3390/molecules26206146P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma MicroenvironmentFernanda Bueno Morrone0Pedro Vargas1Liliana Rockenbach2Thamiris Becker Scheffel3Laboratório de Farmacologia Aplicada, Escola de Ciências da Saúde e da Vida, PUCRS, Porto Alegre 90610-001, RS, BrazilLaboratório de Farmacologia Aplicada, Escola de Ciências da Saúde e da Vida, PUCRS, Porto Alegre 90610-001, RS, BrazilLaboratório de Farmacologia Aplicada, Escola de Ciências da Saúde e da Vida, PUCRS, Porto Alegre 90610-001, RS, BrazilLaboratório de Farmacologia Aplicada, Escola de Ciências da Saúde e da Vida, PUCRS, Porto Alegre 90610-001, RS, BrazilGliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals and immunomodulatory pathways, which increase the tumor’s aggressiveness. In response to hypoxia and glioma therapy, the amounts of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) strongly increase in the extracellular space, and the purinergic signaling is triggered by nucleotides’ interaction in P2 receptors. Several cell types are present in the tumor microenvironment and can facilitate tumor growth. In fact, tumor cells can activate platelets by the ADP-P2Y<sub>12</sub> engagement, which plays an essential role in the cancer context, protecting tumors from the immune attack and providing molecules that contribute to the growth and maintenance of a rich environment to sustain the protumor cycle. Besides platelets, the P2Y<sub>12</sub> receptor is expressed by some tumors, such as renal carcinoma, colon carcinoma, and gliomas, being related to tumor progression. In this context, this review aims to depict the glioma microenvironment, focusing on the relationship between platelets and tumor malignancy.https://www.mdpi.com/1420-3049/26/20/6146purinergic signalingP2Y<sub>12</sub>gliomatumor microenvironmentplatelets |
| spellingShingle | Fernanda Bueno Morrone Pedro Vargas Liliana Rockenbach Thamiris Becker Scheffel P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment Molecules purinergic signaling P2Y<sub>12</sub> glioma tumor microenvironment platelets |
| title | P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment |
| title_full | P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment |
| title_fullStr | P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment |
| title_full_unstemmed | P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment |
| title_short | P2Y<sub>12</sub> Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment |
| title_sort | p2y sub 12 sub purinergic receptor and brain tumors implications on glioma microenvironment |
| topic | purinergic signaling P2Y<sub>12</sub> glioma tumor microenvironment platelets |
| url | https://www.mdpi.com/1420-3049/26/20/6146 |
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