Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice
The protective effects of ‘ofada’ rice koji (ORK, fermented ofada rice) and ascorbic acid (AA) against lead (Pb)-induced toxicity in the blood, liver and kidney tissues of male Wistar rats was investigated. The animals were divided into four treatment groups (A – D, n = 5). Groups B, C and D were in...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Turkish Science and Technology Publishing (TURSTEP)
2015-10-01
|
| Series: | Turkish Journal of Agriculture: Food Science and Technology |
| Subjects: | |
| Online Access: | http://www.agrifoodscience.com/index.php/TURJAF/article/view/436 |
| _version_ | 1797909703232061440 |
|---|---|
| author | Eferhire Aganbi Oghenetega Jonathan Avwioroko Emmanuel Rex Enabulele Onyeka Joshua Osagu Chinedu Kennis Uwandu Assumpta Ike Aaron Akpede Prince Eferusuoa |
| author_facet | Eferhire Aganbi Oghenetega Jonathan Avwioroko Emmanuel Rex Enabulele Onyeka Joshua Osagu Chinedu Kennis Uwandu Assumpta Ike Aaron Akpede Prince Eferusuoa |
| author_sort | Eferhire Aganbi |
| collection | DOAJ |
| description | The protective effects of ‘ofada’ rice koji (ORK, fermented ofada rice) and ascorbic acid (AA) against lead (Pb)-induced toxicity in the blood, liver and kidney tissues of male Wistar rats was investigated. The animals were divided into four treatment groups (A – D, n = 5). Groups B, C and D were intoxified by intra-peritoneal injection of 75 mg lead acetate/kg body weight. Groups C and D only had their feed mixed with ORK and AA, respectively. The results showed no significant difference in % packed cell volume (PCV) and Pb concentrations. Feeding with ORK and AA significantly decreased alanine aminotransferase activities (36.50 ± 3.54 and 34.02 ± 0.05 UL-1 respectively) compared to Pb-only treated group (85.50 ± 3.25 UL-1). The ferric reducing antioxidant power (FRAP) for organs increased significantly following intake of feeds mixed with ORK and AA; increases in FRAP was higher for ORK-treated group possibly due to increased total flavonoids concentration following fermentation. Furthermore, Pb-induced high plasma creatinine levels decreased upon treatment with feeds mixed with ORK and ascorbic acid. These findings strongly indicated that feed supplementation with ORK by 45% may be more effective at ameliorating the effects of Pb-induced toxicity in tissues compared to supplementation with AA by 2%. |
| first_indexed | 2024-04-10T11:12:44Z |
| format | Article |
| id | doaj.art-9f79aaec47ce45daa6465c899e0bf078 |
| institution | Directory Open Access Journal |
| issn | 2148-127X |
| language | English |
| last_indexed | 2024-04-10T11:12:44Z |
| publishDate | 2015-10-01 |
| publisher | Turkish Science and Technology Publishing (TURSTEP) |
| record_format | Article |
| series | Turkish Journal of Agriculture: Food Science and Technology |
| spelling | doaj.art-9f79aaec47ce45daa6465c899e0bf0782023-02-15T16:19:00ZengTurkish Science and Technology Publishing (TURSTEP)Turkish Journal of Agriculture: Food Science and Technology2148-127X2015-10-013975475910.24925/turjaf.v3i9.754-759.436216Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada RiceEferhire Aganbi0Oghenetega Jonathan Avwioroko1Emmanuel Rex Enabulele2Onyeka Joshua Osagu3Chinedu Kennis Uwandu4Assumpta Ike5Aaron Akpede6Prince Eferusuoa7Department of Biochemistry, Faculty of Science, P.M.B 1 Delta State University AbrakaAfrican Research Laboratories Otorho-Agbon, Delta State NigeriaDepartment of Biochemistry Delta State UniversityDepartment of Biochemistry Delta State UniversityBiochemistry, Delta State UniversityBiochemistry, Delta State UniversityBiochemistry, Delta State UniversityBiochemistry, Delta State UniversityThe protective effects of ‘ofada’ rice koji (ORK, fermented ofada rice) and ascorbic acid (AA) against lead (Pb)-induced toxicity in the blood, liver and kidney tissues of male Wistar rats was investigated. The animals were divided into four treatment groups (A – D, n = 5). Groups B, C and D were intoxified by intra-peritoneal injection of 75 mg lead acetate/kg body weight. Groups C and D only had their feed mixed with ORK and AA, respectively. The results showed no significant difference in % packed cell volume (PCV) and Pb concentrations. Feeding with ORK and AA significantly decreased alanine aminotransferase activities (36.50 ± 3.54 and 34.02 ± 0.05 UL-1 respectively) compared to Pb-only treated group (85.50 ± 3.25 UL-1). The ferric reducing antioxidant power (FRAP) for organs increased significantly following intake of feeds mixed with ORK and AA; increases in FRAP was higher for ORK-treated group possibly due to increased total flavonoids concentration following fermentation. Furthermore, Pb-induced high plasma creatinine levels decreased upon treatment with feeds mixed with ORK and ascorbic acid. These findings strongly indicated that feed supplementation with ORK by 45% may be more effective at ameliorating the effects of Pb-induced toxicity in tissues compared to supplementation with AA by 2%.http://www.agrifoodscience.com/index.php/TURJAF/article/view/436Ofada riceLead-induced toxicityTotal flavonoidsAntioxidants FRAP assay |
| spellingShingle | Eferhire Aganbi Oghenetega Jonathan Avwioroko Emmanuel Rex Enabulele Onyeka Joshua Osagu Chinedu Kennis Uwandu Assumpta Ike Aaron Akpede Prince Eferusuoa Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice Turkish Journal of Agriculture: Food Science and Technology Ofada rice Lead-induced toxicity Total flavonoids Antioxidants FRAP assay |
| title | Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice |
| title_full | Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice |
| title_fullStr | Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice |
| title_full_unstemmed | Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice |
| title_short | Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice |
| title_sort | amelioration of lead induced toxicity in blood liver and kidney tissues of male wistar rats by fermented ofada rice |
| topic | Ofada rice Lead-induced toxicity Total flavonoids Antioxidants FRAP assay |
| url | http://www.agrifoodscience.com/index.php/TURJAF/article/view/436 |
| work_keys_str_mv | AT eferhireaganbi ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice AT oghenetegajonathanavwioroko ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice AT emmanuelrexenabulele ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice AT onyekajoshuaosagu ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice AT chinedukennisuwandu ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice AT assumptaike ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice AT aaronakpede ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice AT princeeferusuoa ameliorationofleadinducedtoxicityinbloodliverandkidneytissuesofmalewistarratsbyfermentedofadarice |