Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study
Background Evidence on the associations of carotid intima‐media thickness and carotid plaque characteristics with stroke subtypes and coronary artery disease risks in Asians is limited. This study investigated these associations in the Japanese general population. Methods and Results Maximum intima‐...
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.017020 |
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| author | Saeko Shimoda Akihiko Kitamura Hironori Imano Renzhe Cui Isao Muraki Kazumasa Yamagishi Mitsumasa Umesawa Tomoko Sankai Mina Hayama‐Terada Yasuhiko Kubota Yuji Shimizu Takeo Okada Masahiko Kiyama Hiroyasu Iso |
| author_facet | Saeko Shimoda Akihiko Kitamura Hironori Imano Renzhe Cui Isao Muraki Kazumasa Yamagishi Mitsumasa Umesawa Tomoko Sankai Mina Hayama‐Terada Yasuhiko Kubota Yuji Shimizu Takeo Okada Masahiko Kiyama Hiroyasu Iso |
| author_sort | Saeko Shimoda |
| collection | DOAJ |
| description | Background Evidence on the associations of carotid intima‐media thickness and carotid plaque characteristics with stroke subtypes and coronary artery disease risks in Asians is limited. This study investigated these associations in the Japanese general population. Methods and Results Maximum intima‐media thicknesses of both the common carotid artery and internal carotid artery and carotid plaque characteristics were evaluated in 2943 Japanese subjects aged 40 to 75 years without history of cardiovascular disease. Subjects were followed up for a median of 15.1 years. Using a multivariate Cox proportional hazard model, we found that hazard ratios (HRs) and 95% CIs for the highest (≥1.07 mm) versus lowest (≤0.77 mm) quartiles of maximum intima‐media thicknesses of the common carotid artery were 1.97 (1.26–3.06) for total stroke, 1.52 (0.67–3.41) for hemorrhagic stroke, 2.45 (1.41–4.27) for ischemic stroke, 3.60 (1.64–7.91) for lacunar infarction, 1.53 (0.69–3.41) for nonlacunar cerebral infarction, 2.68 (1.24–5.76) for coronary artery disease, and 2.11 (1.44–3.12) for cardiovascular disease (similar results were found for maximum intima‐media thicknesses of the internal carotid artery). HRs(95% CIs) for heterogeneous plaque versus no plaque were 1.58 (1.09–2.30) for total stroke, 1.25 (0.58–2.70) for hemorrhagic stroke, 1.74 (1.13–2.67) for ischemic stroke, 1.84 (1.03–3.19) for lacunar infarction, 1.58 (0.80–3.11) for nonlacunar cerebral infarction, 2.11 (1.20–3.70) for coronary artery disease, and 1.71 (1.25–2.35) for cardiovascular disease. Conclusions Maximum intima‐media thicknesses of the common carotid artery, maximum intima‐media thicknesses of the internal carotid artery, and heterogeneous plaque were associated with the risks of stroke, lacunar infarction, coronary artery disease, and cardiovascular disease in Asians. |
| first_indexed | 2024-12-22T20:48:34Z |
| format | Article |
| id | doaj.art-9f7b232f55284bf5ab5c7106d3fb9a3f |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T20:48:34Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-9f7b232f55284bf5ab5c7106d3fb9a3f2022-12-21T18:13:09ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-10-0191910.1161/JAHA.120.017020Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities StudySaeko Shimoda0Akihiko Kitamura1Hironori Imano2Renzhe Cui3Isao Muraki4Kazumasa Yamagishi5Mitsumasa Umesawa6Tomoko Sankai7Mina Hayama‐Terada8Yasuhiko Kubota9Yuji Shimizu10Takeo Okada11Masahiko Kiyama12Hiroyasu Iso13Public Health, Department of Social Medicine Osaka University Graduate School of Medicine Osaka JapanPublic Health, Department of Social Medicine Osaka University Graduate School of Medicine Osaka JapanPublic Health, Department of Social Medicine Osaka University Graduate School of Medicine Osaka JapanPublic Health, Department of Social Medicine Osaka University Graduate School of Medicine Osaka JapanPublic Health, Department of Social Medicine Osaka University Graduate School of Medicine Osaka JapanOsaka Center for Cancer and Cardiovascular Disease Prevention Osaka JapanDepartment of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center University of Tsukuba Ibaraki JapanDepartment of Public Health and Nursing, Faculty of Medicine University of Tsukuba Ibaraki JapanOsaka Center for Cancer and Cardiovascular Disease Prevention Osaka JapanOsaka Center for Cancer and Cardiovascular Disease Prevention Osaka JapanOsaka Center for Cancer and Cardiovascular Disease Prevention Osaka JapanOsaka Center for Cancer and Cardiovascular Disease Prevention Osaka JapanOsaka Center for Cancer and Cardiovascular Disease Prevention Osaka JapanPublic Health, Department of Social Medicine Osaka University Graduate School of Medicine Osaka JapanBackground Evidence on the associations of carotid intima‐media thickness and carotid plaque characteristics with stroke subtypes and coronary artery disease risks in Asians is limited. This study investigated these associations in the Japanese general population. Methods and Results Maximum intima‐media thicknesses of both the common carotid artery and internal carotid artery and carotid plaque characteristics were evaluated in 2943 Japanese subjects aged 40 to 75 years without history of cardiovascular disease. Subjects were followed up for a median of 15.1 years. Using a multivariate Cox proportional hazard model, we found that hazard ratios (HRs) and 95% CIs for the highest (≥1.07 mm) versus lowest (≤0.77 mm) quartiles of maximum intima‐media thicknesses of the common carotid artery were 1.97 (1.26–3.06) for total stroke, 1.52 (0.67–3.41) for hemorrhagic stroke, 2.45 (1.41–4.27) for ischemic stroke, 3.60 (1.64–7.91) for lacunar infarction, 1.53 (0.69–3.41) for nonlacunar cerebral infarction, 2.68 (1.24–5.76) for coronary artery disease, and 2.11 (1.44–3.12) for cardiovascular disease (similar results were found for maximum intima‐media thicknesses of the internal carotid artery). HRs(95% CIs) for heterogeneous plaque versus no plaque were 1.58 (1.09–2.30) for total stroke, 1.25 (0.58–2.70) for hemorrhagic stroke, 1.74 (1.13–2.67) for ischemic stroke, 1.84 (1.03–3.19) for lacunar infarction, 1.58 (0.80–3.11) for nonlacunar cerebral infarction, 2.11 (1.20–3.70) for coronary artery disease, and 1.71 (1.25–2.35) for cardiovascular disease. Conclusions Maximum intima‐media thicknesses of the common carotid artery, maximum intima‐media thicknesses of the internal carotid artery, and heterogeneous plaque were associated with the risks of stroke, lacunar infarction, coronary artery disease, and cardiovascular disease in Asians.https://www.ahajournals.org/doi/10.1161/JAHA.120.017020carotid intima‐media thicknesscoronary artery diseaselacunar infarctplaquestroke |
| spellingShingle | Saeko Shimoda Akihiko Kitamura Hironori Imano Renzhe Cui Isao Muraki Kazumasa Yamagishi Mitsumasa Umesawa Tomoko Sankai Mina Hayama‐Terada Yasuhiko Kubota Yuji Shimizu Takeo Okada Masahiko Kiyama Hiroyasu Iso Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease carotid intima‐media thickness coronary artery disease lacunar infarct plaque stroke |
| title | Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study |
| title_full | Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study |
| title_fullStr | Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study |
| title_full_unstemmed | Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study |
| title_short | Associations of Carotid Intima‐Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study |
| title_sort | associations of carotid intima media thickness and plaque heterogeneity with the risks of stroke subtypes and coronary artery disease in the japanese general population the circulatory risk in communities study |
| topic | carotid intima‐media thickness coronary artery disease lacunar infarct plaque stroke |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.017020 |
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