A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide
A new fluorescent sensor for the detection of CN<sup>−</sup> was developed based on the conjugation of phenothiazine fluorophore and benzofuran unit. By the nucleophilic attacking of CN<sup>−</sup> to the fluoroacetylamino group in the sensor, the additional reaction of CN<...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/14/1/51 |
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| author | Yulei Li Chen Zhou Jiaxin Li Jing Sun |
| author_facet | Yulei Li Chen Zhou Jiaxin Li Jing Sun |
| author_sort | Yulei Li |
| collection | DOAJ |
| description | A new fluorescent sensor for the detection of CN<sup>−</sup> was developed based on the conjugation of phenothiazine fluorophore and benzofuran unit. By the nucleophilic attacking of CN<sup>−</sup> to the fluoroacetylamino group in the sensor, the additional reaction of CN<sup>−</sup> and carbonyl group induced the ICT (intramolecular charge transfer) effect in the molecule and caused the fluorescence quenching sensor. The titration experiments show that the sensor has good sensitivity, selectivity and quick response for CN<sup>−</sup>. In addition, the fluorescent detection of CN<sup>−</sup> in the living cell and zebrafish experiments demonstrated the value of the sensor in tracing the CN<sup>−</sup> in biological systems. |
| first_indexed | 2024-03-08T11:03:31Z |
| format | Article |
| id | doaj.art-9f7b5654ca834ba2aac6fe26d92bb090 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-08T11:03:31Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-9f7b5654ca834ba2aac6fe26d92bb0902024-01-26T15:23:22ZengMDPI AGBiosensors2079-63742024-01-011415110.3390/bios14010051A New Phenothiazine-Based Fluorescent Sensor for Detection of CyanideYulei Li0Chen Zhou1Jiaxin Li2Jing Sun3School of Chemistry & Environmental Engineering, Jilin Provincial International Joint Research Center of Photo-Functional Materials and Chemistry, Changchun University of Science and Technology, Changchun 130022, ChinaSchool of Chemistry & Environmental Engineering, Jilin Provincial International Joint Research Center of Photo-Functional Materials and Chemistry, Changchun University of Science and Technology, Changchun 130022, ChinaSchool of Chemistry & Environmental Engineering, Jilin Provincial International Joint Research Center of Photo-Functional Materials and Chemistry, Changchun University of Science and Technology, Changchun 130022, ChinaSchool of Chemistry & Environmental Engineering, Jilin Provincial International Joint Research Center of Photo-Functional Materials and Chemistry, Changchun University of Science and Technology, Changchun 130022, ChinaA new fluorescent sensor for the detection of CN<sup>−</sup> was developed based on the conjugation of phenothiazine fluorophore and benzofuran unit. By the nucleophilic attacking of CN<sup>−</sup> to the fluoroacetylamino group in the sensor, the additional reaction of CN<sup>−</sup> and carbonyl group induced the ICT (intramolecular charge transfer) effect in the molecule and caused the fluorescence quenching sensor. The titration experiments show that the sensor has good sensitivity, selectivity and quick response for CN<sup>−</sup>. In addition, the fluorescent detection of CN<sup>−</sup> in the living cell and zebrafish experiments demonstrated the value of the sensor in tracing the CN<sup>−</sup> in biological systems.https://www.mdpi.com/2079-6374/14/1/51cyanidefluorescent sensorphenothiazine |
| spellingShingle | Yulei Li Chen Zhou Jiaxin Li Jing Sun A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide Biosensors cyanide fluorescent sensor phenothiazine |
| title | A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide |
| title_full | A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide |
| title_fullStr | A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide |
| title_full_unstemmed | A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide |
| title_short | A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide |
| title_sort | new phenothiazine based fluorescent sensor for detection of cyanide |
| topic | cyanide fluorescent sensor phenothiazine |
| url | https://www.mdpi.com/2079-6374/14/1/51 |
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