Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19
Abstract Background We experienced that some hemodialysis (HD) patients with coronavirus disease 2019 (COVID-19) exacerbated hypoxemia during HD. Though HD-induced hypoxemia has been reported, there have been no reports of HD-induced hypoxemia in patients with COVID-19 and its effect on prognosis of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Renal Replacement Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41100-022-00408-5 |
| _version_ | 1811339910362169344 |
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| author | Masataro Toda Ayumi Yoshifuji Kentaro Fujii Motoaki Komatsu Ai Kato Ikue Tamura Wataru Sugi Munekazu Ryuzaki |
| author_facet | Masataro Toda Ayumi Yoshifuji Kentaro Fujii Motoaki Komatsu Ai Kato Ikue Tamura Wataru Sugi Munekazu Ryuzaki |
| author_sort | Masataro Toda |
| collection | DOAJ |
| description | Abstract Background We experienced that some hemodialysis (HD) patients with coronavirus disease 2019 (COVID-19) exacerbated hypoxemia during HD. Though HD-induced hypoxemia has been reported, there have been no reports of HD-induced hypoxemia in patients with COVID-19 and its effect on prognosis of COVID-19. Methods Eleven HD patients admitted with COVID-19 from August 2020 to April 2021 were classified into the patients whose oxygen demand increased by more than 3 L/min with mask during HD (worsened group, n = 5) and others (not-worsened group, n = 6). The background, laboratory findings, severity of COVID-19 and prognosis were compared between the two groups. In addition, blood gases were measured before and after dialysis among HD patients admitted with COVID-19 on April 2021 (n = 3). Results There were no significant differences in backgrounds, except for a higher proportion of diabetes mellitus in worsened group (p = 0.04). Although laboratory findings were not significantly different on admission day, albumin and LDH levels 7 days after admission were significantly lower and higher in worsened group, respectively (p = 0.03 and < 0.01). The severity of COVID-19 and survival rate were significantly worse in worsened group (p = 0.01 and 0.03). The alveolar-arterial oxygen pressure difference (Aa-DO2) opened during HD in a patient with HD-induced hypoxemia, but did not open in patients without HD-induced hypoxemia. Conclusions There is a close relationship among HD-induced hypoxemia and poor prognosis of COVID-19. The HD-induced hypoxemia of patients with COVID-19 may be caused by ventilation/perfusion mismatching. |
| first_indexed | 2024-04-13T18:33:25Z |
| format | Article |
| id | doaj.art-9f7c47cab00f42458f1a3548b8dd26c2 |
| institution | Directory Open Access Journal |
| issn | 2059-1381 |
| language | English |
| last_indexed | 2024-04-13T18:33:25Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Renal Replacement Therapy |
| spelling | doaj.art-9f7c47cab00f42458f1a3548b8dd26c22022-12-22T02:34:58ZengBMCRenal Replacement Therapy2059-13812022-05-01811710.1186/s41100-022-00408-5Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19Masataro Toda0Ayumi Yoshifuji1Kentaro Fujii2Motoaki Komatsu3Ai Kato4Ikue Tamura5Wataru Sugi6Munekazu Ryuzaki7Department of Nephrology, Tokyo Saiseikai Central HospitalDepartment of Nephrology, Tokyo Saiseikai Central HospitalDepartment of Nephrology, Tokyo Saiseikai Central HospitalDepartment of Nephrology, Tokyo Saiseikai Central HospitalDepartment of Nephrology, Tokyo Saiseikai Central HospitalDepartment of Nephrology, Tokyo Saiseikai Central HospitalDepartment of Nephrology, Tokyo Saiseikai Central HospitalDepartment of Nephrology, Tokyo Saiseikai Central HospitalAbstract Background We experienced that some hemodialysis (HD) patients with coronavirus disease 2019 (COVID-19) exacerbated hypoxemia during HD. Though HD-induced hypoxemia has been reported, there have been no reports of HD-induced hypoxemia in patients with COVID-19 and its effect on prognosis of COVID-19. Methods Eleven HD patients admitted with COVID-19 from August 2020 to April 2021 were classified into the patients whose oxygen demand increased by more than 3 L/min with mask during HD (worsened group, n = 5) and others (not-worsened group, n = 6). The background, laboratory findings, severity of COVID-19 and prognosis were compared between the two groups. In addition, blood gases were measured before and after dialysis among HD patients admitted with COVID-19 on April 2021 (n = 3). Results There were no significant differences in backgrounds, except for a higher proportion of diabetes mellitus in worsened group (p = 0.04). Although laboratory findings were not significantly different on admission day, albumin and LDH levels 7 days after admission were significantly lower and higher in worsened group, respectively (p = 0.03 and < 0.01). The severity of COVID-19 and survival rate were significantly worse in worsened group (p = 0.01 and 0.03). The alveolar-arterial oxygen pressure difference (Aa-DO2) opened during HD in a patient with HD-induced hypoxemia, but did not open in patients without HD-induced hypoxemia. Conclusions There is a close relationship among HD-induced hypoxemia and poor prognosis of COVID-19. The HD-induced hypoxemia of patients with COVID-19 may be caused by ventilation/perfusion mismatching.https://doi.org/10.1186/s41100-022-00408-5COVID-19HemodialysisHypoxemiaCytokine storm |
| spellingShingle | Masataro Toda Ayumi Yoshifuji Kentaro Fujii Motoaki Komatsu Ai Kato Ikue Tamura Wataru Sugi Munekazu Ryuzaki Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19 Renal Replacement Therapy COVID-19 Hemodialysis Hypoxemia Cytokine storm |
| title | Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19 |
| title_full | Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19 |
| title_fullStr | Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19 |
| title_full_unstemmed | Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19 |
| title_short | Patients with hemodialysis-induced hypoxemia had a poor prognosis of COVID-19 |
| title_sort | patients with hemodialysis induced hypoxemia had a poor prognosis of covid 19 |
| topic | COVID-19 Hemodialysis Hypoxemia Cytokine storm |
| url | https://doi.org/10.1186/s41100-022-00408-5 |
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