A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines.
Community-acquired bacterial bloodstream infections are caused by diverse pathogens with changing antimicrobial-resistance patterns. In low-middle income countries in Southeast Asia, where dengue fever is endemic and a leading cause of fever, limited information is available about bacterial bloodstr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-05-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0010414 |
| _version_ | 1811290603961450496 |
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| author | Nobuo Saito Rontgene M Solante Ferdinand D Guzman Elizabeth O Telan Dorcas V Umipig Joy P Calayo Carina H Frayco Jezreel C Lazaro Maricel R Ribo Alexis Q Dimapilis Virginia O Dimapilis Annavi M Villanueva Jaira L Mauhay Motoi Suzuki Michio Yasunami Nobuo Koizumi Emi Kitashoji Kentaro Sakashita Ikkoh Yasuda Akira Nishiyama Chris Smith Koya Ariyoshi Christopher M Parry |
| author_facet | Nobuo Saito Rontgene M Solante Ferdinand D Guzman Elizabeth O Telan Dorcas V Umipig Joy P Calayo Carina H Frayco Jezreel C Lazaro Maricel R Ribo Alexis Q Dimapilis Virginia O Dimapilis Annavi M Villanueva Jaira L Mauhay Motoi Suzuki Michio Yasunami Nobuo Koizumi Emi Kitashoji Kentaro Sakashita Ikkoh Yasuda Akira Nishiyama Chris Smith Koya Ariyoshi Christopher M Parry |
| author_sort | Nobuo Saito |
| collection | DOAJ |
| description | Community-acquired bacterial bloodstream infections are caused by diverse pathogens with changing antimicrobial-resistance patterns. In low-middle income countries in Southeast Asia, where dengue fever is endemic and a leading cause of fever, limited information is available about bacterial bloodstream infections due to challenges of implementing a blood culture service. This study describes bacterial bloodstream pathogens and antimicrobial-resistance patterns in Metro Manila, the Philippines. We aimed to identify the proportion of patients with a positive blood culture, the bacteria isolated and their antimicrobial resistance patterns, and the clinical characteristics of these patients, in this dengue endemic area. We conducted a prospective observational study in a single hospital enrolling febrile patients clinically suspected of having a community-acquired bacterial bloodstream infection between 1st July 2015 and 30th June 2019. Each patient had a blood culture and additional diagnostic tests according to their clinical presentation. We enrolled 1315 patients and a significant positive blood culture was found in 77 (5.9%) including Staphylococcus aureus (n = 20), Salmonella enterica Typhi (n = 18), Escherichia coli (n = 16), Streptococcus pneumoniae (n = 3) and Burkholderia pseudomallei (n = 2). Thirty-four patients had meningococcal disease diagnosed by culture (n = 8) or blood PCR (n = 26). Additional confirmed diagnoses included leptospirosis (n = 177), dengue virus infection (n = 159) and respiratory diphtheria (n = 50). There were 79 (6.0%, 95%CI 4.8%-7.4%) patients who died within 28 days of enrollment. Patients with a positive blood culture were significantly more likely to die than patients with negative culture (15.2% vs 4.4%, P<0.01). Among S. aureus isolates, 11/20 (55%) were methicillin-resistant (MRSA) and ST30: USA1100 was dominant sequence type (88.9%). Antimicrobial-susceptibility was well preserved in S. enterica Typhi. Among hospitalized patients with clinically suspected community-acquired bacterial bloodstream infection in Metro Manila, the Philippines, 5.9% had a blood culture confirmed infection of whom 15.6% died. S. aureus, including a significant number of MRSA (USA1100 clones), S. enterica Typhi, E.coli and Neisseria meningitidis were frequently identified pathogens. |
| first_indexed | 2024-04-13T04:15:36Z |
| format | Article |
| id | doaj.art-9f7c6e4400cc4972a956c6bcf20dd6b3 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-13T04:15:36Z |
| publishDate | 2022-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-9f7c6e4400cc4972a956c6bcf20dd6b32022-12-22T03:02:59ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352022-05-01165e001041410.1371/journal.pntd.0010414A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines.Nobuo SaitoRontgene M SolanteFerdinand D GuzmanElizabeth O TelanDorcas V UmipigJoy P CalayoCarina H FraycoJezreel C LazaroMaricel R RiboAlexis Q DimapilisVirginia O DimapilisAnnavi M VillanuevaJaira L MauhayMotoi SuzukiMichio YasunamiNobuo KoizumiEmi KitashojiKentaro SakashitaIkkoh YasudaAkira NishiyamaChris SmithKoya AriyoshiChristopher M ParryCommunity-acquired bacterial bloodstream infections are caused by diverse pathogens with changing antimicrobial-resistance patterns. In low-middle income countries in Southeast Asia, where dengue fever is endemic and a leading cause of fever, limited information is available about bacterial bloodstream infections due to challenges of implementing a blood culture service. This study describes bacterial bloodstream pathogens and antimicrobial-resistance patterns in Metro Manila, the Philippines. We aimed to identify the proportion of patients with a positive blood culture, the bacteria isolated and their antimicrobial resistance patterns, and the clinical characteristics of these patients, in this dengue endemic area. We conducted a prospective observational study in a single hospital enrolling febrile patients clinically suspected of having a community-acquired bacterial bloodstream infection between 1st July 2015 and 30th June 2019. Each patient had a blood culture and additional diagnostic tests according to their clinical presentation. We enrolled 1315 patients and a significant positive blood culture was found in 77 (5.9%) including Staphylococcus aureus (n = 20), Salmonella enterica Typhi (n = 18), Escherichia coli (n = 16), Streptococcus pneumoniae (n = 3) and Burkholderia pseudomallei (n = 2). Thirty-four patients had meningococcal disease diagnosed by culture (n = 8) or blood PCR (n = 26). Additional confirmed diagnoses included leptospirosis (n = 177), dengue virus infection (n = 159) and respiratory diphtheria (n = 50). There were 79 (6.0%, 95%CI 4.8%-7.4%) patients who died within 28 days of enrollment. Patients with a positive blood culture were significantly more likely to die than patients with negative culture (15.2% vs 4.4%, P<0.01). Among S. aureus isolates, 11/20 (55%) were methicillin-resistant (MRSA) and ST30: USA1100 was dominant sequence type (88.9%). Antimicrobial-susceptibility was well preserved in S. enterica Typhi. Among hospitalized patients with clinically suspected community-acquired bacterial bloodstream infection in Metro Manila, the Philippines, 5.9% had a blood culture confirmed infection of whom 15.6% died. S. aureus, including a significant number of MRSA (USA1100 clones), S. enterica Typhi, E.coli and Neisseria meningitidis were frequently identified pathogens.https://doi.org/10.1371/journal.pntd.0010414 |
| spellingShingle | Nobuo Saito Rontgene M Solante Ferdinand D Guzman Elizabeth O Telan Dorcas V Umipig Joy P Calayo Carina H Frayco Jezreel C Lazaro Maricel R Ribo Alexis Q Dimapilis Virginia O Dimapilis Annavi M Villanueva Jaira L Mauhay Motoi Suzuki Michio Yasunami Nobuo Koizumi Emi Kitashoji Kentaro Sakashita Ikkoh Yasuda Akira Nishiyama Chris Smith Koya Ariyoshi Christopher M Parry A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines. PLoS Neglected Tropical Diseases |
| title | A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines. |
| title_full | A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines. |
| title_fullStr | A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines. |
| title_full_unstemmed | A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines. |
| title_short | A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines. |
| title_sort | prospective observational study of community acquired bacterial bloodstream infections in metro manila the philippines |
| url | https://doi.org/10.1371/journal.pntd.0010414 |
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