Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing
A bioterror event using an infectious bacterium may lead to catastrophic outcomes involving morbidity and mortality as well as social and psychological stress. Moreover, a bioterror event using an antibiotic resistance engineered bacterial agent may raise additional concerns. Thus, preparedness is e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/9/7/1535 |
| _version_ | 1797526545316708352 |
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| author | Shahar Rotem Ida Steinberger-Levy Ofir Israeli Eran Zahavy Ronit Aloni-Grinstein |
| author_facet | Shahar Rotem Ida Steinberger-Levy Ofir Israeli Eran Zahavy Ronit Aloni-Grinstein |
| author_sort | Shahar Rotem |
| collection | DOAJ |
| description | A bioterror event using an infectious bacterium may lead to catastrophic outcomes involving morbidity and mortality as well as social and psychological stress. Moreover, a bioterror event using an antibiotic resistance engineered bacterial agent may raise additional concerns. Thus, preparedness is essential to preclude and control the dissemination of the bacterial agent as well as to appropriately and promptly treat potentially exposed individuals or patients. Rates of morbidity, death, and social anxiety can be drastically reduced if the rapid delivery of antimicrobial agents for post-exposure prophylaxis and treatment is initiated as soon as possible. Availability of rapid antibiotic susceptibility tests that may provide key recommendations to targeted antibiotic treatment is mandatory, yet, such tests are only at the development stage. In this review, we describe the recently published rapid antibiotic susceptibility tests implemented on bioterror bacterial agents and discuss their assimilation in clinical and environmental samples. |
| first_indexed | 2024-03-10T09:31:39Z |
| format | Article |
| id | doaj.art-9f7cb5184bac484ba9807e12b5fde85a |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T09:31:39Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-9f7cb5184bac484ba9807e12b5fde85a2023-11-22T04:27:14ZengMDPI AGMicroorganisms2076-26072021-07-0197153510.3390/microorganisms9071535Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility TestingShahar Rotem0Ida Steinberger-Levy1Ofir Israeli2Eran Zahavy3Ronit Aloni-Grinstein4Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 74100, IsraelDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 74100, IsraelDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 74100, IsraelDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 74100, IsraelDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 74100, IsraelA bioterror event using an infectious bacterium may lead to catastrophic outcomes involving morbidity and mortality as well as social and psychological stress. Moreover, a bioterror event using an antibiotic resistance engineered bacterial agent may raise additional concerns. Thus, preparedness is essential to preclude and control the dissemination of the bacterial agent as well as to appropriately and promptly treat potentially exposed individuals or patients. Rates of morbidity, death, and social anxiety can be drastically reduced if the rapid delivery of antimicrobial agents for post-exposure prophylaxis and treatment is initiated as soon as possible. Availability of rapid antibiotic susceptibility tests that may provide key recommendations to targeted antibiotic treatment is mandatory, yet, such tests are only at the development stage. In this review, we describe the recently published rapid antibiotic susceptibility tests implemented on bioterror bacterial agents and discuss their assimilation in clinical and environmental samples.https://www.mdpi.com/2076-2607/9/7/1535bioterror<i>Bacillus anthracis</i><i>Yersinia pestis</i><i>Francisella tularensis</i>antibioticclinical samples |
| spellingShingle | Shahar Rotem Ida Steinberger-Levy Ofir Israeli Eran Zahavy Ronit Aloni-Grinstein Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing Microorganisms bioterror <i>Bacillus anthracis</i> <i>Yersinia pestis</i> <i>Francisella tularensis</i> antibiotic clinical samples |
| title | Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing |
| title_full | Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing |
| title_fullStr | Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing |
| title_full_unstemmed | Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing |
| title_short | Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing |
| title_sort | beating the bio terror threat with rapid antimicrobial susceptibility testing |
| topic | bioterror <i>Bacillus anthracis</i> <i>Yersinia pestis</i> <i>Francisella tularensis</i> antibiotic clinical samples |
| url | https://www.mdpi.com/2076-2607/9/7/1535 |
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