Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients
Neuron-specific enolase (NSE) is a glycolytic enzyme present almost exclusively in neurons and neuroendocrine cells. NSE levels in cerebrospinal fluid (CSF) are assumed to be useful to estimate neuronal injury and clinical outcome of patients with serious clinical manifestations such as those observ...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2004-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100003 |
| _version_ | 1818513844829421568 |
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| author | J.E. Lima O.M. Takayanagui L.V. Garcia J.P. Leite |
| author_facet | J.E. Lima O.M. Takayanagui L.V. Garcia J.P. Leite |
| author_sort | J.E. Lima |
| collection | DOAJ |
| description | Neuron-specific enolase (NSE) is a glycolytic enzyme present almost exclusively in neurons and neuroendocrine cells. NSE levels in cerebrospinal fluid (CSF) are assumed to be useful to estimate neuronal injury and clinical outcome of patients with serious clinical manifestations such as those observed in stroke, head injury, anoxic encephalopathy, encephalitis, brain metastasis, and status epilepticus. We compared levels of NSE in serum (sNSE) and in CSF (cNSE) among four groups: patients with meningitis (N = 11), patients with encephalic injuries associated with impairment of consciousness (ENC, N = 7), patients with neurocysticercosis (N = 25), and normal subjects (N = 8). Albumin was determined in serum and CSF samples, and the albumin quotient was used to estimate blood-brain barrier permeability. The Glasgow Coma Scale score was calculated at the time of lumbar puncture and the Glasgow Outcome Scale (GOS) score was calculated at the time of patient discharge or death. The ENC group had significantly higher cNSE (P = 0.01) and albumin quotient (P = 0.005), but not sNSE (P = 0.14), levels than the other groups (Kruskal-Wallis test). Patients with lower GOS scores had higher cNSE levels (P = 0.035) than patients with favorable outcomes. Our findings indicate that sNSE is not sensitive enough to detect neuronal damage, but cNSE seems to be reliable for assessing patients with considerable neurological insult and cases with adverse outcome. However, one should be cautious about estimating the severity of neurological status as well as outcome based exclusively on cNSE in a single patient. |
| first_indexed | 2024-12-11T00:07:08Z |
| format | Article |
| id | doaj.art-9f7d2abfdea941f89027f1ae098c55b0 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-11T00:07:08Z |
| publishDate | 2004-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-9f7d2abfdea941f89027f1ae098c55b02022-12-22T01:28:17ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2004-01-01371192610.1590/S0100-879X2004000100003Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patientsJ.E. LimaO.M. TakayanaguiL.V. GarciaJ.P. LeiteNeuron-specific enolase (NSE) is a glycolytic enzyme present almost exclusively in neurons and neuroendocrine cells. NSE levels in cerebrospinal fluid (CSF) are assumed to be useful to estimate neuronal injury and clinical outcome of patients with serious clinical manifestations such as those observed in stroke, head injury, anoxic encephalopathy, encephalitis, brain metastasis, and status epilepticus. We compared levels of NSE in serum (sNSE) and in CSF (cNSE) among four groups: patients with meningitis (N = 11), patients with encephalic injuries associated with impairment of consciousness (ENC, N = 7), patients with neurocysticercosis (N = 25), and normal subjects (N = 8). Albumin was determined in serum and CSF samples, and the albumin quotient was used to estimate blood-brain barrier permeability. The Glasgow Coma Scale score was calculated at the time of lumbar puncture and the Glasgow Outcome Scale (GOS) score was calculated at the time of patient discharge or death. The ENC group had significantly higher cNSE (P = 0.01) and albumin quotient (P = 0.005), but not sNSE (P = 0.14), levels than the other groups (Kruskal-Wallis test). Patients with lower GOS scores had higher cNSE levels (P = 0.035) than patients with favorable outcomes. Our findings indicate that sNSE is not sensitive enough to detect neuronal damage, but cNSE seems to be reliable for assessing patients with considerable neurological insult and cases with adverse outcome. However, one should be cautious about estimating the severity of neurological status as well as outcome based exclusively on cNSE in a single patient.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100003Neuronal damageNeuron-specific enolaseCerebrospinal fluidAlbumin quotient |
| spellingShingle | J.E. Lima O.M. Takayanagui L.V. Garcia J.P. Leite Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients Brazilian Journal of Medical and Biological Research Neuronal damage Neuron-specific enolase Cerebrospinal fluid Albumin quotient |
| title | Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients |
| title_full | Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients |
| title_fullStr | Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients |
| title_full_unstemmed | Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients |
| title_short | Use of neuron-specific enolase for assessing the severity and outcome of neurological disorders in patients |
| title_sort | use of neuron specific enolase for assessing the severity and outcome of neurological disorders in patients |
| topic | Neuronal damage Neuron-specific enolase Cerebrospinal fluid Albumin quotient |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100003 |
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