Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

Abstract Background Rhinoviruses (RVs) cause more than half of common colds and, in some cases, more severe diseases. Functional genomics analyses of RVs using siRNA or genome-wide CRISPR screen uncovered a limited set of host factors, few of which have proven clinical relevance. Results Herein, we...

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Bibliographic Details
Main Authors: Hong Mei, Zhao Zha, Wei Wang, Yusang Xie, Yuege Huang, Wenping Li, Dong Wei, Xinxin Zhang, Jieming Qu, Jia Liu
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Genome Biology
Subjects:
CRISPR
Genome-wide screen
Surfaceome screen
Rhinovirus
OLFML3
Online Access:https://doi.org/10.1186/s13059-021-02513-w

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