Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma
Qiao Yang,1 Yue Hua Nie,1 Man Bo Cai,1 Zhi Min Li,1 Hong Bo Zhu,2 Ye Ru Tan2 1Department of Oncology Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of China; 2Department of Medical Oncology, The First Affiliated Ho...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-04-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/gemcitabine-combined-with-cisplatin-has-a-better-effect-in-the-treatme-peer-reviewed-fulltext-article-DDDT |
| _version_ | 1818276174382497792 |
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| author | Yang Q Nie YH Cai MB Li ZM Zhu HB Tan YR |
| author_facet | Yang Q Nie YH Cai MB Li ZM Zhu HB Tan YR |
| author_sort | Yang Q |
| collection | DOAJ |
| description | Qiao Yang,1 Yue Hua Nie,1 Man Bo Cai,1 Zhi Min Li,1 Hong Bo Zhu,2 Ye Ru Tan2 1Department of Oncology Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of China; 2Department of Medical Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of ChinaCorrespondence: Ye Ru Tan, Department of Medical Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of China, Tel +86 0734-8578759, Email tanyeru@163.comObjective: To explore the efficacy and safety of gemcitabine (GEM) combined with cisplatin (DDP) in the treatment of recurrent/metastatic nasopharyngeal carcinoma (NPC).Methods: A total of 100 patients with recurrent/metastatic NPC treated in the First Affiliated Hospital, Hengyang Medical School, University of South China from January 2018 to March 2020 were retrospectively enrolled. Based on different chemotherapy schemes, they were assigned to an observation (Obs) group (DDP + GEM, n = 55) and a control (Con) group [DDP + FU (fluorouracil), n = 45]. The two groups were compared regarding the following items: therapeutic efficacy; serum levels of platelet-derived growth factor-BB (PDGF-BB), soluble epithelial cadherin (SE-CAD), and inflammation-related factors before and after treatment; toxic and side effects; 1-year survival rate; and quality of life (QOL) 6 months after treatment.Results: The Obs group outperformed the Con group in therapeutic efficacy (P < 0.05). There were no significant differences in the levels of PDGF-BB, SE-CAD, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α between the two groups before treatment (P > 0.05). After treatment, better improvements in PDGF-BB, SE-CAD and inflammatory factors were observed in the Obs group (P < 0.05). The toxic and side effects were significantly lower and the 1-year survival rate and patients’ QOL after 6 months of treatment were significantly higher in the Obs group compared with the Con group (P < 0.05).Conclusion: GEM combined with DDP can provide more clinical benefits for patients with recurrent/metastatic advanced NPC, with less side effects, high tolerance and significant efficacy, which can be further promoted in clinical use.Keywords: gemcitabine, cisplatin, recurrent/metastatic nasopharyngeal carcinoma, efficacy, safety |
| first_indexed | 2024-12-12T22:41:27Z |
| format | Article |
| id | doaj.art-9f7e2e3281b34f47b4a94ced4b11ce9b |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-12T22:41:27Z |
| publishDate | 2022-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-9f7e2e3281b34f47b4a94ced4b11ce9b2022-12-22T00:09:19ZengDove Medical PressDrug Design, Development and Therapy1177-88812022-04-01Volume 161191119874800Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal CarcinomaYang QNie YHCai MBLi ZMZhu HBTan YRQiao Yang,1 Yue Hua Nie,1 Man Bo Cai,1 Zhi Min Li,1 Hong Bo Zhu,2 Ye Ru Tan2 1Department of Oncology Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of China; 2Department of Medical Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of ChinaCorrespondence: Ye Ru Tan, Department of Medical Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of China, Tel +86 0734-8578759, Email tanyeru@163.comObjective: To explore the efficacy and safety of gemcitabine (GEM) combined with cisplatin (DDP) in the treatment of recurrent/metastatic nasopharyngeal carcinoma (NPC).Methods: A total of 100 patients with recurrent/metastatic NPC treated in the First Affiliated Hospital, Hengyang Medical School, University of South China from January 2018 to March 2020 were retrospectively enrolled. Based on different chemotherapy schemes, they were assigned to an observation (Obs) group (DDP + GEM, n = 55) and a control (Con) group [DDP + FU (fluorouracil), n = 45]. The two groups were compared regarding the following items: therapeutic efficacy; serum levels of platelet-derived growth factor-BB (PDGF-BB), soluble epithelial cadherin (SE-CAD), and inflammation-related factors before and after treatment; toxic and side effects; 1-year survival rate; and quality of life (QOL) 6 months after treatment.Results: The Obs group outperformed the Con group in therapeutic efficacy (P < 0.05). There were no significant differences in the levels of PDGF-BB, SE-CAD, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α between the two groups before treatment (P > 0.05). After treatment, better improvements in PDGF-BB, SE-CAD and inflammatory factors were observed in the Obs group (P < 0.05). The toxic and side effects were significantly lower and the 1-year survival rate and patients’ QOL after 6 months of treatment were significantly higher in the Obs group compared with the Con group (P < 0.05).Conclusion: GEM combined with DDP can provide more clinical benefits for patients with recurrent/metastatic advanced NPC, with less side effects, high tolerance and significant efficacy, which can be further promoted in clinical use.Keywords: gemcitabine, cisplatin, recurrent/metastatic nasopharyngeal carcinoma, efficacy, safetyhttps://www.dovepress.com/gemcitabine-combined-with-cisplatin-has-a-better-effect-in-the-treatme-peer-reviewed-fulltext-article-DDDTgemcitabinecisplatinrecurrent/metastatic nasopharyngeal carcinomaefficacysafety. |
| spellingShingle | Yang Q Nie YH Cai MB Li ZM Zhu HB Tan YR Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma Drug Design, Development and Therapy gemcitabine cisplatin recurrent/metastatic nasopharyngeal carcinoma efficacy safety. |
| title | Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma |
| title_full | Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma |
| title_fullStr | Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma |
| title_full_unstemmed | Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma |
| title_short | Gemcitabine Combined with Cisplatin Has a Better Effect in the Treatment of Recurrent/Metastatic Advanced Nasopharyngeal Carcinoma |
| title_sort | gemcitabine combined with cisplatin has a better effect in the treatment of recurrent metastatic advanced nasopharyngeal carcinoma |
| topic | gemcitabine cisplatin recurrent/metastatic nasopharyngeal carcinoma efficacy safety. |
| url | https://www.dovepress.com/gemcitabine-combined-with-cisplatin-has-a-better-effect-in-the-treatme-peer-reviewed-fulltext-article-DDDT |
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