Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumors
PURPOSEWe aimed to explore the influence of tube voltage, current and iterative reconstruction (IR) in computed tomography perfusion imaging (CTPI) and to compare CTPI parameters with microvessel density (MVD).METHODSHepatic CTPI with three CTPI protocols (protocol A, tube voltage/current 80 kV/40 m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2020-07-01
|
| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/nfluence-of-tube-voltage-tube-current-and-newer-it/54713
|
| _version_ | 1797691295664177152 |
|---|---|
| author | Jing-Lei Li Wei-Tao Ye Li-Fen Yan Zai-Yi Liu Xi-Ming Cao Chang-hong Liang |
| author_facet | Jing-Lei Li Wei-Tao Ye Li-Fen Yan Zai-Yi Liu Xi-Ming Cao Chang-hong Liang |
| author_sort | Jing-Lei Li |
| collection | DOAJ |
| description | PURPOSEWe aimed to explore the influence of tube voltage, current and iterative reconstruction (IR) in computed tomography perfusion imaging (CTPI) and to compare CTPI parameters with microvessel density (MVD).METHODSHepatic CTPI with three CTPI protocols (protocol A, tube voltage/current 80 kV/40 mAs; protocol B, tube voltage/current 80 kV/80 mAs; protocol C: tube voltage/current 100 kV/80 mAs) were performed in 25 rabbit liver VX2 tumor models, and filtered back projection (FBP) and IR were used for reconstruction of raw data. Hepatic arterial perfusion (HAP), hepatic portal perfusion (HPP), total perfusion (TP), hepatic arterial perfusion index (HPI), blood flow (BF) and blood volume (BV) of VX2 tumor and normal hepatic parenchyma were measured. Image noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were quantified and radiation dose was recorded. MVD was counted using CD34 stain and compared with CTPI parameters.RESULTSThe highest radiation dose was found in protocol C, followed by protocols B and A. IR lowered image noise and improved SNR and CNR in all three protocols. There was no statistical difference between HAP, HPP, TP, HPI, BF and BV of VX2 tumor and normal hepatic parenchyma among the three protocols (P > 0.05) with FBP or IR reconstruction, and no statistical difference between IR and FBP reconstruction (P > 0.05) in either protocol. MVD had a positive linear correlation with HAP, TP, BF, with best correlation observed with HAP; MVD of VX2 tumor showed no or poor correlation with HPI and BV.CONCLUSIONCTPI parameters are not affected by tube voltage, current or reconstruction algorithm; HAP can best reflect MVD, but no correlation exists between BV and MVD. |
| first_indexed | 2024-03-12T02:11:23Z |
| format | Article |
| id | doaj.art-9f8083ae63f74c9fbe0730fc4203154a |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:11:23Z |
| publishDate | 2020-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-9f8083ae63f74c9fbe0730fc4203154a2023-09-06T13:00:27ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122020-07-0126426427010.5152/dir.2019.1914713049054Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumorsJing-Lei Li0Wei-Tao Ye1Li-Fen Yan2Zai-Yi Liu3Xi-Ming Cao4Chang-hong Liang5 Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China PURPOSEWe aimed to explore the influence of tube voltage, current and iterative reconstruction (IR) in computed tomography perfusion imaging (CTPI) and to compare CTPI parameters with microvessel density (MVD).METHODSHepatic CTPI with three CTPI protocols (protocol A, tube voltage/current 80 kV/40 mAs; protocol B, tube voltage/current 80 kV/80 mAs; protocol C: tube voltage/current 100 kV/80 mAs) were performed in 25 rabbit liver VX2 tumor models, and filtered back projection (FBP) and IR were used for reconstruction of raw data. Hepatic arterial perfusion (HAP), hepatic portal perfusion (HPP), total perfusion (TP), hepatic arterial perfusion index (HPI), blood flow (BF) and blood volume (BV) of VX2 tumor and normal hepatic parenchyma were measured. Image noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were quantified and radiation dose was recorded. MVD was counted using CD34 stain and compared with CTPI parameters.RESULTSThe highest radiation dose was found in protocol C, followed by protocols B and A. IR lowered image noise and improved SNR and CNR in all three protocols. There was no statistical difference between HAP, HPP, TP, HPI, BF and BV of VX2 tumor and normal hepatic parenchyma among the three protocols (P > 0.05) with FBP or IR reconstruction, and no statistical difference between IR and FBP reconstruction (P > 0.05) in either protocol. MVD had a positive linear correlation with HAP, TP, BF, with best correlation observed with HAP; MVD of VX2 tumor showed no or poor correlation with HPI and BV.CONCLUSIONCTPI parameters are not affected by tube voltage, current or reconstruction algorithm; HAP can best reflect MVD, but no correlation exists between BV and MVD. http://www.dirjournal.org/archives/archive-detail/article-preview/nfluence-of-tube-voltage-tube-current-and-newer-it/54713 |
| spellingShingle | Jing-Lei Li Wei-Tao Ye Li-Fen Yan Zai-Yi Liu Xi-Ming Cao Chang-hong Liang Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumors Diagnostic and Interventional Radiology |
| title | Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumors |
| title_full | Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumors |
| title_fullStr | Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumors |
| title_full_unstemmed | Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumors |
| title_short | Influence of tube voltage, tube current and newer iterative reconstruction algorithms in CT perfusion imaging in rabbit liver VX2 tumors |
| title_sort | influence of tube voltage tube current and newer iterative reconstruction algorithms in ct perfusion imaging in rabbit liver vx2 tumors |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/nfluence-of-tube-voltage-tube-current-and-newer-it/54713
|
| work_keys_str_mv | AT jingleili influenceoftubevoltagetubecurrentandneweriterativereconstructionalgorithmsinctperfusionimaginginrabbitlivervx2tumors AT weitaoye influenceoftubevoltagetubecurrentandneweriterativereconstructionalgorithmsinctperfusionimaginginrabbitlivervx2tumors AT lifenyan influenceoftubevoltagetubecurrentandneweriterativereconstructionalgorithmsinctperfusionimaginginrabbitlivervx2tumors AT zaiyiliu influenceoftubevoltagetubecurrentandneweriterativereconstructionalgorithmsinctperfusionimaginginrabbitlivervx2tumors AT ximingcao influenceoftubevoltagetubecurrentandneweriterativereconstructionalgorithmsinctperfusionimaginginrabbitlivervx2tumors AT changhongliang influenceoftubevoltagetubecurrentandneweriterativereconstructionalgorithmsinctperfusionimaginginrabbitlivervx2tumors |