Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report
<p>Abstract</p> <p>Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder that presents with hemolytic anemia, marrow failure and thrombophilia. During acute attacks, corticosteroid can alleviate the hemolytic paroxysm, but the prolonged administration induces serious toxic...
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
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| Online Access: | http://www.ann-clinmicrob.com/content/11/1/12 |
| _version_ | 1811260247553081344 |
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| author | Lee Jihyun Gong Soojung Lee Byounghoon Lee Soyoung Lee Jungae Kim Naeyu |
| author_facet | Lee Jihyun Gong Soojung Lee Byounghoon Lee Soyoung Lee Jungae Kim Naeyu |
| author_sort | Lee Jihyun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder that presents with hemolytic anemia, marrow failure and thrombophilia. During acute attacks, corticosteroid can alleviate the hemolytic paroxysm, but the prolonged administration induces serious toxicity including immunosuppression. So American thoracic society (ATS) for tuberculosis (TB) recommends prophylactic anti-TB medication in patients with a long-term steroid therapy. However, in the patient who was treated for active TB in the past, there are no guidelines of the test for determining patients who have latent TB infection (LTBI) and no recommendations of TB prophylaxis if there is no evidence of reactivation at present. A 40-year-old male patient presented with fever and aggravated weakness for a week. He was diagnosed with PNH a month ago and took corticosteroid for 3 weeks. In the past, he was diagnosed with pulmonary TB and completely cured after treatment. According to guideline, he was not indicated with TB prophylaxis. However, he caught miliary TB, progressed to acute respiratory distress syndrome. We experience this embarrassing case, and emphasize the need to investigate multicentral TB prevalence and to make the guidelines of anti-TB medication in subgroups of hematologic diseases including PNH.</p> |
| first_indexed | 2024-04-12T18:44:32Z |
| format | Article |
| id | doaj.art-9f816409745f48d9908f490be47cbdc2 |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-04-12T18:44:32Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-9f816409745f48d9908f490be47cbdc22022-12-22T03:20:40ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112012-05-011111210.1186/1476-0711-11-12Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case reportLee JihyunGong SoojungLee ByounghoonLee SoyoungLee JungaeKim Naeyu<p>Abstract</p> <p>Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder that presents with hemolytic anemia, marrow failure and thrombophilia. During acute attacks, corticosteroid can alleviate the hemolytic paroxysm, but the prolonged administration induces serious toxicity including immunosuppression. So American thoracic society (ATS) for tuberculosis (TB) recommends prophylactic anti-TB medication in patients with a long-term steroid therapy. However, in the patient who was treated for active TB in the past, there are no guidelines of the test for determining patients who have latent TB infection (LTBI) and no recommendations of TB prophylaxis if there is no evidence of reactivation at present. A 40-year-old male patient presented with fever and aggravated weakness for a week. He was diagnosed with PNH a month ago and took corticosteroid for 3 weeks. In the past, he was diagnosed with pulmonary TB and completely cured after treatment. According to guideline, he was not indicated with TB prophylaxis. However, he caught miliary TB, progressed to acute respiratory distress syndrome. We experience this embarrassing case, and emphasize the need to investigate multicentral TB prevalence and to make the guidelines of anti-TB medication in subgroups of hematologic diseases including PNH.</p>http://www.ann-clinmicrob.com/content/11/1/12Paroxysmal nocturnal hemoglobinuriaMiliary tuberculosis (TB)Tuberculosis (TB) prophylaxis |
| spellingShingle | Lee Jihyun Gong Soojung Lee Byounghoon Lee Soyoung Lee Jungae Kim Naeyu Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report Annals of Clinical Microbiology and Antimicrobials Paroxysmal nocturnal hemoglobinuria Miliary tuberculosis (TB) Tuberculosis (TB) prophylaxis |
| title | Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report |
| title_full | Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report |
| title_fullStr | Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report |
| title_full_unstemmed | Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report |
| title_short | Miliary tuberculosis occurred after immunosuppressive drug in PNH patient with completely cured tuberculosis; a case report |
| title_sort | miliary tuberculosis occurred after immunosuppressive drug in pnh patient with completely cured tuberculosis a case report |
| topic | Paroxysmal nocturnal hemoglobinuria Miliary tuberculosis (TB) Tuberculosis (TB) prophylaxis |
| url | http://www.ann-clinmicrob.com/content/11/1/12 |
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