Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial
Abstract Individuals with multi-domain amnestic mild cognitive impairment (md-aMCI) have an elevated risk of dementia and need interventions that may retain or remediate cognitive function. In a feasibility pilot study, 30 older adults aged 60–80 years with md-aMCI were randomized to 8 sessions of t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34582-1 |
| _version_ | 1827948138356277248 |
|---|---|
| author | Kevin T. Jones Avery E. Ostrand Adam Gazzaley Theodore P. Zanto |
| author_facet | Kevin T. Jones Avery E. Ostrand Adam Gazzaley Theodore P. Zanto |
| author_sort | Kevin T. Jones |
| collection | DOAJ |
| description | Abstract Individuals with multi-domain amnestic mild cognitive impairment (md-aMCI) have an elevated risk of dementia and need interventions that may retain or remediate cognitive function. In a feasibility pilot study, 30 older adults aged 60–80 years with md-aMCI were randomized to 8 sessions of transcranial alternating current stimulation (tACS) with simultaneous cognitive control training (CCT). The intervention took place within the participant’s home without direct researcher assistance. Half of the participants received prefrontal theta tACS during CCT and the other half received control tACS. We observed high tolerability and adherence for at-home tACS + CCT. Within 1-week, only those who received theta tACS exhibited improved attentional abilities. Neuromodulation is feasible for in-home settings, which can be conducted by the patient, thereby enabling treatment in difficult to reach populations. TACS with CCT may facilitate cognitive control abilities in md-aMCI, but research in a larger population is needed to validate efficacy. |
| first_indexed | 2024-04-09T12:50:42Z |
| format | Article |
| id | doaj.art-9f8206b9f0e444d589580b5afc3f07b5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T12:50:42Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9f8206b9f0e444d589580b5afc3f07b52023-05-14T11:15:16ZengNature PortfolioScientific Reports2045-23222023-05-0113111110.1038/s41598-023-34582-1Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trialKevin T. Jones0Avery E. Ostrand1Adam Gazzaley2Theodore P. Zanto3Department of Neurology, University of California-San FranciscoDepartment of Neurology, University of California-San FranciscoDepartment of Neurology, University of California-San FranciscoDepartment of Neurology, University of California-San FranciscoAbstract Individuals with multi-domain amnestic mild cognitive impairment (md-aMCI) have an elevated risk of dementia and need interventions that may retain or remediate cognitive function. In a feasibility pilot study, 30 older adults aged 60–80 years with md-aMCI were randomized to 8 sessions of transcranial alternating current stimulation (tACS) with simultaneous cognitive control training (CCT). The intervention took place within the participant’s home without direct researcher assistance. Half of the participants received prefrontal theta tACS during CCT and the other half received control tACS. We observed high tolerability and adherence for at-home tACS + CCT. Within 1-week, only those who received theta tACS exhibited improved attentional abilities. Neuromodulation is feasible for in-home settings, which can be conducted by the patient, thereby enabling treatment in difficult to reach populations. TACS with CCT may facilitate cognitive control abilities in md-aMCI, but research in a larger population is needed to validate efficacy.https://doi.org/10.1038/s41598-023-34582-1 |
| spellingShingle | Kevin T. Jones Avery E. Ostrand Adam Gazzaley Theodore P. Zanto Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial Scientific Reports |
| title | Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial |
| title_full | Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial |
| title_fullStr | Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial |
| title_full_unstemmed | Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial |
| title_short | Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial |
| title_sort | enhancing cognitive control in amnestic mild cognitive impairment via at home non invasive neuromodulation in a randomized trial |
| url | https://doi.org/10.1038/s41598-023-34582-1 |
| work_keys_str_mv | AT kevintjones enhancingcognitivecontrolinamnesticmildcognitiveimpairmentviaathomenoninvasiveneuromodulationinarandomizedtrial AT averyeostrand enhancingcognitivecontrolinamnesticmildcognitiveimpairmentviaathomenoninvasiveneuromodulationinarandomizedtrial AT adamgazzaley enhancingcognitivecontrolinamnesticmildcognitiveimpairmentviaathomenoninvasiveneuromodulationinarandomizedtrial AT theodorepzanto enhancingcognitivecontrolinamnesticmildcognitiveimpairmentviaathomenoninvasiveneuromodulationinarandomizedtrial |