The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy
Gene regulation: linking enhancers to specific promoters Super-enhancers are regions of DNA that highly activate the expression of specific genes. Research led by H.K.L. and L.H. at the National Institutes of Health, USA, now demonstrate that a super-enhancer is much more effective when operating in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-04-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-0425-x |
| _version_ | 1818972146176622592 |
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| author | Xianke Zeng Hye Kyung Lee Chaochen Wang Precious Achikeh Chengyu Liu Lothar Hennighausen |
| author_facet | Xianke Zeng Hye Kyung Lee Chaochen Wang Precious Achikeh Chengyu Liu Lothar Hennighausen |
| author_sort | Xianke Zeng |
| collection | DOAJ |
| description | Gene regulation: linking enhancers to specific promoters Super-enhancers are regions of DNA that highly activate the expression of specific genes. Research led by H.K.L. and L.H. at the National Institutes of Health, USA, now demonstrate that a super-enhancer is much more effective when operating in synergy with its associated promoter, another gene-controlling element. They investigated super-enhancer and promoter synergy in mouse mammary gland cells. A mammary super-enhancer achieved a 5-fold activation of a gene with a common promoter, in contrast to an 80-fold activation with its own promoter together. The findings reveal that this synergy is critical for gene regulation in the mammary gland during pregnancy and lactation. They also help resolve the general issue of whether super-enhancers act independently or, as found here, can work together with a specific promoters in cell-specific genetic programs. |
| first_indexed | 2024-12-20T15:03:38Z |
| format | Article |
| id | doaj.art-9f8264e5a8fe49ebb0fa9c0925b551ba |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-20T15:03:38Z |
| publishDate | 2020-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-9f8264e5a8fe49ebb0fa9c0925b551ba2022-12-21T19:36:34ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-04-0152468269010.1038/s12276-020-0425-xThe interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancyXianke Zeng0Hye Kyung Lee1Chaochen Wang2Precious Achikeh3Chengyu Liu4Lothar Hennighausen5Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of HealthLaboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of HealthLaboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of HealthLaboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of HealthTransgenic Core, National Heart, Lung, and Blood Institute, US National Institutes of HealthLaboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of HealthGene regulation: linking enhancers to specific promoters Super-enhancers are regions of DNA that highly activate the expression of specific genes. Research led by H.K.L. and L.H. at the National Institutes of Health, USA, now demonstrate that a super-enhancer is much more effective when operating in synergy with its associated promoter, another gene-controlling element. They investigated super-enhancer and promoter synergy in mouse mammary gland cells. A mammary super-enhancer achieved a 5-fold activation of a gene with a common promoter, in contrast to an 80-fold activation with its own promoter together. The findings reveal that this synergy is critical for gene regulation in the mammary gland during pregnancy and lactation. They also help resolve the general issue of whether super-enhancers act independently or, as found here, can work together with a specific promoters in cell-specific genetic programs.https://doi.org/10.1038/s12276-020-0425-x |
| spellingShingle | Xianke Zeng Hye Kyung Lee Chaochen Wang Precious Achikeh Chengyu Liu Lothar Hennighausen The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy Experimental and Molecular Medicine |
| title | The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy |
| title_full | The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy |
| title_fullStr | The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy |
| title_full_unstemmed | The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy |
| title_short | The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy |
| title_sort | interdependence of mammary specific super enhancers and their native promoters facilitates gene activation during pregnancy |
| url | https://doi.org/10.1038/s12276-020-0425-x |
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