The vascular perspective on acute and chronic lung disease
The pulmonary vasculature has been frequently overlooked in acute and chronic lung diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and chronic obstructive pulmonary disease (COPD). The primary emphasis in the management of these parenchymal disorders has largel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2023-08-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI170502 |
| _version_ | 1827768128170360832 |
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| author | Izabela Borek Anna Birnhuber Norbert F. Voelkel Leigh M. Marsh Grazyna Kwapiszewska |
| author_facet | Izabela Borek Anna Birnhuber Norbert F. Voelkel Leigh M. Marsh Grazyna Kwapiszewska |
| author_sort | Izabela Borek |
| collection | DOAJ |
| description | The pulmonary vasculature has been frequently overlooked in acute and chronic lung diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and chronic obstructive pulmonary disease (COPD). The primary emphasis in the management of these parenchymal disorders has largely revolved around the injury and aberrant repair of epithelial cells. However, there is increasing evidence that the vascular endothelium plays an active role in the development of acute and chronic lung diseases. The endothelial cell network in the capillary bed and the arterial and venous vessels provides a metabolically highly active barrier that controls the migration of immune cells, regulates vascular tone and permeability, and participates in the remodeling processes. Phenotypically and functionally altered endothelial cells, and remodeled vessels, can be found in acute and chronic lung diseases, although to different degrees, likely because of disease-specific mechanisms. Since vascular remodeling is associated with pulmonary hypertension, which worsens patient outcomes and survival, it is crucial to understand the underlying vascular alterations. In this Review, we describe the current knowledge regarding the role of the pulmonary vasculature in the development and progression of ARDS, PF, and COPD; we also outline future research directions with the hope of facilitating the development of mechanism-based therapies. |
| first_indexed | 2024-03-11T12:08:00Z |
| format | Article |
| id | doaj.art-9f86419b4baa4a8a9a38e9a7a3558ac3 |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:08:00Z |
| publishDate | 2023-08-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-9f86419b4baa4a8a9a38e9a7a3558ac32023-11-07T16:20:44ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-08-0113316The vascular perspective on acute and chronic lung diseaseIzabela BorekAnna BirnhuberNorbert F. VoelkelLeigh M. MarshGrazyna KwapiszewskaThe pulmonary vasculature has been frequently overlooked in acute and chronic lung diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and chronic obstructive pulmonary disease (COPD). The primary emphasis in the management of these parenchymal disorders has largely revolved around the injury and aberrant repair of epithelial cells. However, there is increasing evidence that the vascular endothelium plays an active role in the development of acute and chronic lung diseases. The endothelial cell network in the capillary bed and the arterial and venous vessels provides a metabolically highly active barrier that controls the migration of immune cells, regulates vascular tone and permeability, and participates in the remodeling processes. Phenotypically and functionally altered endothelial cells, and remodeled vessels, can be found in acute and chronic lung diseases, although to different degrees, likely because of disease-specific mechanisms. Since vascular remodeling is associated with pulmonary hypertension, which worsens patient outcomes and survival, it is crucial to understand the underlying vascular alterations. In this Review, we describe the current knowledge regarding the role of the pulmonary vasculature in the development and progression of ARDS, PF, and COPD; we also outline future research directions with the hope of facilitating the development of mechanism-based therapies.https://doi.org/10.1172/JCI170502 |
| spellingShingle | Izabela Borek Anna Birnhuber Norbert F. Voelkel Leigh M. Marsh Grazyna Kwapiszewska The vascular perspective on acute and chronic lung disease The Journal of Clinical Investigation |
| title | The vascular perspective on acute and chronic lung disease |
| title_full | The vascular perspective on acute and chronic lung disease |
| title_fullStr | The vascular perspective on acute and chronic lung disease |
| title_full_unstemmed | The vascular perspective on acute and chronic lung disease |
| title_short | The vascular perspective on acute and chronic lung disease |
| title_sort | vascular perspective on acute and chronic lung disease |
| url | https://doi.org/10.1172/JCI170502 |
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