Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis
BackgroundProbiotics has been reported as an effective supplement for Helicobacter pylori eradication. However, knowledge of their comparative efficacy is still lacking.AimIn this study, we used network meta-analysis of current probiotics supplement used in standard triple therapy to assess and rank...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1120789/full |
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| author | Yue Wang Xue Wang Xue-Yan Cao Han-Long Zhu Lin Miao |
| author_facet | Yue Wang Xue Wang Xue-Yan Cao Han-Long Zhu Lin Miao |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | BackgroundProbiotics has been reported as an effective supplement for Helicobacter pylori eradication. However, knowledge of their comparative efficacy is still lacking.AimIn this study, we used network meta-analysis of current probiotics supplement used in standard triple therapy to assess and rank their comparative effectiveness.MethodsAll randomized controlled trials from three main databases (PubMed, Embase and Cochrane Library) up to April 2022 were collected and filtered to meet our criterion. We used Bayesian network meta-analysis to evaluate the eligible randomized controlled trials and gave a rank for the efficiency and incidence of side effects of each probiotics supplement. The ranking probability for each therapy was assessed by means of surfaces under cumulative ranking values. Subgroup analysis was conducted to evaluate other possible influencing factors.Results34 eligible randomized controlled trials entered the following meta-analysis, including 9,004 patients randomized to 10 kinds of therapies. Result showed that most probiotics added therapies had better outcomes than triple therapy, among which Bifidobacterium-Lactobacillus and Bifidobacterium-Lactobacillus-Saccharomyces adjuvant therapy could obtain comprehensive benefit with high eradication rate (78.3% and 88.2% respectively), and cause few side effects. Combination of different probiotics, adding probiotics before or after triple therapy and longer duration of probiotics can improve therapeutic effect in H.pylori infected individuals.ConclusionFor triple therapy of H.pylori infection, adding probiotics can increase eradication rate and bring protective effect. Considering the overall influence, Bifidobacterium-Lactobacillus or Bifidobacterium-Lactobacillus-Saccharomyces therapy can be a better choice in improving H.pylori eradication process. |
| first_indexed | 2024-04-09T12:38:55Z |
| format | Article |
| id | doaj.art-9f87f95f720644e2ac9d5ea047b736d4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T12:38:55Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-9f87f95f720644e2ac9d5ea047b736d42023-05-15T04:45:47ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-05-011310.3389/fcimb.2023.11207891120789Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysisYue Wang0Xue Wang1Xue-Yan Cao2Han-Long Zhu3Lin Miao4Medical Centre for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaMedical Centre for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaMedical Centre for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Gastroenterology and Hepatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, ChinaMedical Centre for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaBackgroundProbiotics has been reported as an effective supplement for Helicobacter pylori eradication. However, knowledge of their comparative efficacy is still lacking.AimIn this study, we used network meta-analysis of current probiotics supplement used in standard triple therapy to assess and rank their comparative effectiveness.MethodsAll randomized controlled trials from three main databases (PubMed, Embase and Cochrane Library) up to April 2022 were collected and filtered to meet our criterion. We used Bayesian network meta-analysis to evaluate the eligible randomized controlled trials and gave a rank for the efficiency and incidence of side effects of each probiotics supplement. The ranking probability for each therapy was assessed by means of surfaces under cumulative ranking values. Subgroup analysis was conducted to evaluate other possible influencing factors.Results34 eligible randomized controlled trials entered the following meta-analysis, including 9,004 patients randomized to 10 kinds of therapies. Result showed that most probiotics added therapies had better outcomes than triple therapy, among which Bifidobacterium-Lactobacillus and Bifidobacterium-Lactobacillus-Saccharomyces adjuvant therapy could obtain comprehensive benefit with high eradication rate (78.3% and 88.2% respectively), and cause few side effects. Combination of different probiotics, adding probiotics before or after triple therapy and longer duration of probiotics can improve therapeutic effect in H.pylori infected individuals.ConclusionFor triple therapy of H.pylori infection, adding probiotics can increase eradication rate and bring protective effect. Considering the overall influence, Bifidobacterium-Lactobacillus or Bifidobacterium-Lactobacillus-Saccharomyces therapy can be a better choice in improving H.pylori eradication process.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1120789/fullhelicobacter pyloritreatmentprobioticsefficacy and safetynetwork meta-analysis |
| spellingShingle | Yue Wang Xue Wang Xue-Yan Cao Han-Long Zhu Lin Miao Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis Frontiers in Cellular and Infection Microbiology helicobacter pylori treatment probiotics efficacy and safety network meta-analysis |
| title | Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis |
| title_full | Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis |
| title_fullStr | Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis |
| title_full_unstemmed | Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis |
| title_short | Comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication: a network meta-analysis |
| title_sort | comparative effectiveness of different probiotics supplements for triple helicobacter pylori eradication a network meta analysis |
| topic | helicobacter pylori treatment probiotics efficacy and safety network meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1120789/full |
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