Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery
The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only all...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/8/1151 |
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| author | Lu Tang Jing Li Qingqing Zhao Ting Pan Hui Zhong Wei Wang |
| author_facet | Lu Tang Jing Li Qingqing Zhao Ting Pan Hui Zhong Wei Wang |
| author_sort | Lu Tang |
| collection | DOAJ |
| description | The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only allow cancer-specific drug delivery by inherent passive targeting phenomena and adopting active targeting strategies, but also improve the pharmacokinetics and bioavailability of the loaded drugs, leading to enhanced therapeutic efficacy and safety compared to conventional treatment modalities. Small molecule drugs are the most widely used anticancer agents at present, while biological macromolecules, such as therapeutic antibodies, peptides and genes, have gained increasing attention. Therefore, this review focuses on the recent achievements of novel nano-encapsulation in targeted drug delivery. A comprehensive introduction of intelligent delivery strategies based on various nanocarriers to encapsulate small molecule chemotherapeutic drugs and biological macromolecule drugs in cancer treatment will also be highlighted. |
| first_indexed | 2024-03-10T08:29:28Z |
| format | Article |
| id | doaj.art-9f8ab3df17a44a7f8ca0b663b3c084f6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:29:28Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9f8ab3df17a44a7f8ca0b663b3c084f62023-11-22T09:13:24ZengMDPI AGPharmaceutics1999-49232021-07-01138115110.3390/pharmaceutics13081151Advanced and Innovative Nano-Systems for Anticancer Targeted Drug DeliveryLu Tang0Jing Li1Qingqing Zhao2Ting Pan3Hui Zhong4Wei Wang5State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaState Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaThe encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only allow cancer-specific drug delivery by inherent passive targeting phenomena and adopting active targeting strategies, but also improve the pharmacokinetics and bioavailability of the loaded drugs, leading to enhanced therapeutic efficacy and safety compared to conventional treatment modalities. Small molecule drugs are the most widely used anticancer agents at present, while biological macromolecules, such as therapeutic antibodies, peptides and genes, have gained increasing attention. Therefore, this review focuses on the recent achievements of novel nano-encapsulation in targeted drug delivery. A comprehensive introduction of intelligent delivery strategies based on various nanocarriers to encapsulate small molecule chemotherapeutic drugs and biological macromolecule drugs in cancer treatment will also be highlighted.https://www.mdpi.com/1999-4923/13/8/1151nanotechnologyencapsulation strategytargeted drug deliverycancer therapychemotherapeuticsbiopharmaceutics |
| spellingShingle | Lu Tang Jing Li Qingqing Zhao Ting Pan Hui Zhong Wei Wang Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery Pharmaceutics nanotechnology encapsulation strategy targeted drug delivery cancer therapy chemotherapeutics biopharmaceutics |
| title | Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery |
| title_full | Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery |
| title_fullStr | Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery |
| title_full_unstemmed | Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery |
| title_short | Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery |
| title_sort | advanced and innovative nano systems for anticancer targeted drug delivery |
| topic | nanotechnology encapsulation strategy targeted drug delivery cancer therapy chemotherapeutics biopharmaceutics |
| url | https://www.mdpi.com/1999-4923/13/8/1151 |
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