Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humans
Electronic cigarettes (ECs), considered a healthier alternative to traditional cigarettes (TCs), vaporize e-liquid, which may produce harmful by-products due to thermal decomposition and metal transfer. These by-products' deposition in the respiratory tract is largely determined by particle siz...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of Hazardous Materials Letters |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266691102300014X |
| _version_ | 1827687023328100352 |
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| author | Li-Ti Chou Tsai-Ling Chen Kai-Chien Yang Hsiao-Chi Chuang Ying-Jiun Chen Ching-Huang Lai Ta-Chih Hsiao |
| author_facet | Li-Ti Chou Tsai-Ling Chen Kai-Chien Yang Hsiao-Chi Chuang Ying-Jiun Chen Ching-Huang Lai Ta-Chih Hsiao |
| author_sort | Li-Ti Chou |
| collection | DOAJ |
| description | Electronic cigarettes (ECs), considered a healthier alternative to traditional cigarettes (TCs), vaporize e-liquid, which may produce harmful by-products due to thermal decomposition and metal transfer. These by-products' deposition in the respiratory tract is largely determined by particle size distribution (PSD). We employ the Multiple-Path Particle Dosimetry (MPPD) model to assess particle deposition within the human and mouse respiratory tracts. Leveraging the known connection between TC smoke inhalation and atherosclerosis, we used human aortic endothelial cells (HAECs) and ApoE-/- mice to explore the potential effects of EC aerosol inhalation on atherosclerosis. Our findings reveal that TCs exhibit a highly variable PSD, with mean diameters of approximately 300 nm for mainstream (MS) smoke and 120 nm for side stream (SS) smoke. Conversely, ECs demonstrate a more stable PSD. Combined with MPPD, the deposition fraction in the human respiratory system and mice is mainly deposited in the pulmonary region and head airway. For the Apoe-/- mice exposure experiment, preliminary findings suggest a potential impact on atherosclerosis, although not statistically significant, likely due to the limited sample size and exposure duration. This study highlights the importance of considering PSD, exposure dosage, and species-specific differences in risk assessments of EC aerosols. |
| first_indexed | 2024-03-10T09:26:48Z |
| format | Article |
| id | doaj.art-9f8b6e7a53e542bdac0e708a67ce0ad4 |
| institution | Directory Open Access Journal |
| issn | 2666-9110 |
| language | English |
| last_indexed | 2024-03-10T09:26:48Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Hazardous Materials Letters |
| spelling | doaj.art-9f8b6e7a53e542bdac0e708a67ce0ad42023-11-22T04:48:51ZengElsevierJournal of Hazardous Materials Letters2666-91102023-11-014100088Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humansLi-Ti Chou0Tsai-Ling Chen1Kai-Chien Yang2Hsiao-Chi Chuang3Ying-Jiun Chen4Ching-Huang Lai5Ta-Chih Hsiao6Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, TaiwanGraduate Institute of Environmental Engineering, National Taiwan University, Taipei, TaiwanDepartment and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan; National Heart and Lung Institute, Imperial College London, London, UK; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanGraduate Institute of Environmental Engineering, National Central University, Taoyuan City, TaiwanSchool of Public Health, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan; Research Centre for Environmental Changes, Academia Sinica, Taipei, Taiwan; Corresponding author at: Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan.Electronic cigarettes (ECs), considered a healthier alternative to traditional cigarettes (TCs), vaporize e-liquid, which may produce harmful by-products due to thermal decomposition and metal transfer. These by-products' deposition in the respiratory tract is largely determined by particle size distribution (PSD). We employ the Multiple-Path Particle Dosimetry (MPPD) model to assess particle deposition within the human and mouse respiratory tracts. Leveraging the known connection between TC smoke inhalation and atherosclerosis, we used human aortic endothelial cells (HAECs) and ApoE-/- mice to explore the potential effects of EC aerosol inhalation on atherosclerosis. Our findings reveal that TCs exhibit a highly variable PSD, with mean diameters of approximately 300 nm for mainstream (MS) smoke and 120 nm for side stream (SS) smoke. Conversely, ECs demonstrate a more stable PSD. Combined with MPPD, the deposition fraction in the human respiratory system and mice is mainly deposited in the pulmonary region and head airway. For the Apoe-/- mice exposure experiment, preliminary findings suggest a potential impact on atherosclerosis, although not statistically significant, likely due to the limited sample size and exposure duration. This study highlights the importance of considering PSD, exposure dosage, and species-specific differences in risk assessments of EC aerosols.http://www.sciencedirect.com/science/article/pii/S266691102300014XE-cigaretteTobacco cigarettesPSDMPPDAtherosclerosis |
| spellingShingle | Li-Ti Chou Tsai-Ling Chen Kai-Chien Yang Hsiao-Chi Chuang Ying-Jiun Chen Ching-Huang Lai Ta-Chih Hsiao Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humans Journal of Hazardous Materials Letters E-cigarette Tobacco cigarettes PSD MPPD Atherosclerosis |
| title | Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humans |
| title_full | Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humans |
| title_fullStr | Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humans |
| title_full_unstemmed | Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humans |
| title_short | Particle size matters: Discrepancies in the health risks posed by traditional cigarettes and e-cigarettes in mice and humans |
| title_sort | particle size matters discrepancies in the health risks posed by traditional cigarettes and e cigarettes in mice and humans |
| topic | E-cigarette Tobacco cigarettes PSD MPPD Atherosclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S266691102300014X |
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