Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia?
Objectives : The aim of the study was to explore the putative significance of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and its correlation with the lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Materials and Methods : ACE I/D polymorphi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Indian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.indianjurol.com/article.asp?issn=0970-1591;year=2010;volume=26;issue=4;spage=497;epage=501;aulast=Bid |
| _version_ | 1818145130348019712 |
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| author | Hemant Kumar Bid Parmeet Kaur Manchanda Rituraj Konwar Kasif Hanif V Laxman Nayak Vishwajeet Singh |
| author_facet | Hemant Kumar Bid Parmeet Kaur Manchanda Rituraj Konwar Kasif Hanif V Laxman Nayak Vishwajeet Singh |
| author_sort | Hemant Kumar Bid |
| collection | DOAJ |
| description | Objectives : The aim of the study was to explore the putative significance of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and its correlation with the lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH).
Materials and Methods : ACE I/D polymorphisms were determined by polymerase chain reaction (PCR) in 200 patients with moderate to severe LUTS due to BPH and 200 patients of same age group without the LUTS having normal size prostate. ACE levels were estimated by spectrophotometer method. Logistic regression models were used to determine the genetic effects using SPSS statistical software (version 12.0).
Results and Conclusions : The distribution of genotypes along with allelic frequency and carriage rate did not significantly differ between study and control groups. This study suggests that I/D polymorphisms within the ACE gene are not associated with the presence of LUTS in BPH patients. Future studies in large cohorts are needed that may reveal the spectrum of cellular mechanism mediated by ACE relevant to pathophysiology of BPH and effect of ethnic differences. |
| first_indexed | 2024-12-11T11:58:34Z |
| format | Article |
| id | doaj.art-9f8c297353184c9089c6930bd8b09bea |
| institution | Directory Open Access Journal |
| issn | 0970-1591 1998-3824 |
| language | English |
| last_indexed | 2024-12-11T11:58:34Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Urology |
| spelling | doaj.art-9f8c297353184c9089c6930bd8b09bea2022-12-22T01:08:07ZengWolters Kluwer Medknow PublicationsIndian Journal of Urology0970-15911998-38242010-01-0126449750110.4103/0970-1591.74438Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia?Hemant Kumar BidParmeet Kaur ManchandaRituraj KonwarKasif HanifV Laxman NayakVishwajeet SinghObjectives : The aim of the study was to explore the putative significance of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and its correlation with the lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Materials and Methods : ACE I/D polymorphisms were determined by polymerase chain reaction (PCR) in 200 patients with moderate to severe LUTS due to BPH and 200 patients of same age group without the LUTS having normal size prostate. ACE levels were estimated by spectrophotometer method. Logistic regression models were used to determine the genetic effects using SPSS statistical software (version 12.0). Results and Conclusions : The distribution of genotypes along with allelic frequency and carriage rate did not significantly differ between study and control groups. This study suggests that I/D polymorphisms within the ACE gene are not associated with the presence of LUTS in BPH patients. Future studies in large cohorts are needed that may reveal the spectrum of cellular mechanism mediated by ACE relevant to pathophysiology of BPH and effect of ethnic differences.http://www.indianjurol.com/article.asp?issn=0970-1591;year=2010;volume=26;issue=4;spage=497;epage=501;aulast=Bidangiotensin-converting enzyme polymorphismpolymerase chain reaction-RFLPbenign prostatic hyperplasia |
| spellingShingle | Hemant Kumar Bid Parmeet Kaur Manchanda Rituraj Konwar Kasif Hanif V Laxman Nayak Vishwajeet Singh Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? Indian Journal of Urology angiotensin-converting enzyme polymorphism polymerase chain reaction-RFLP benign prostatic hyperplasia |
| title | Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? |
| title_full | Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? |
| title_fullStr | Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? |
| title_full_unstemmed | Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? |
| title_short | Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? |
| title_sort | does angiotensin converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia |
| topic | angiotensin-converting enzyme polymorphism polymerase chain reaction-RFLP benign prostatic hyperplasia |
| url | http://www.indianjurol.com/article.asp?issn=0970-1591;year=2010;volume=26;issue=4;spage=497;epage=501;aulast=Bid |
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