Genipin crosslinking promotes biomechanical reinforcement and pro-regenerative macrophage polarization in bioartificial tubular substitutes

Genipin crosslinking promotes biomechanical reinforcement and pro-regenerative macrophage polarization in bioartificial tubular substitutes

Traumatic nerve injuries are nowadays a significant clinical challenge and new substitutes with adequate biological and mechanical properties are in need. In this context, fibrin-agarose hydrogels (FA) have shown the possibility to generate tubular scaffolds with promising results for nerve repair....

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Bibliographic Details
Main Authors: Jone Berasain, Paula Ávila-Fernández, Rocío Cárdenas-Pérez, Antoni Ignasi Cànaves-Llabrés, Miguel Etayo-Escanilla, Miguel Alaminos, Víctor Carriel, Óscar Darío García-García, Jesús Chato-Astrain, Fernando Campos
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Peripheral nerve
Fibrin-agarose
Genipin
Biomechanical properties
Macrophage polarization
Anti-inflammatory response
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003330

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http://www.sciencedirect.com/science/article/pii/S0753332224003330

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