Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patterns
Abstract Background The clinical profiles of recurrent retroperitoneal liposarcoma (RLS) need to be explored. The recurrence patterns of RLS are controversial and ambiguous. Methods A total of 138 patients with recurrent RLS were finally recruited in the study. The analysis of overall survival (OS)...
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| Format: | Article |
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BMC
2023-11-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11586-8 |
| _version_ | 1797630182125731840 |
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| author | Huan Deng Jingwang Gao Xingming Xu Guibin Liu Liqiang Song Yisheng Pan Bo Wei |
| author_facet | Huan Deng Jingwang Gao Xingming Xu Guibin Liu Liqiang Song Yisheng Pan Bo Wei |
| author_sort | Huan Deng |
| collection | DOAJ |
| description | Abstract Background The clinical profiles of recurrent retroperitoneal liposarcoma (RLS) need to be explored. The recurrence patterns of RLS are controversial and ambiguous. Methods A total of 138 patients with recurrent RLS were finally recruited in the study. The analysis of overall survival (OS) and recurrence-free survival (RFS) was performed by Kaplan‒Meier analysis. To identify independent prognostic factors, all significant variables on univariate Cox regression analysis (P ≤ 0.05) were subjected to multivariate Cox regression analysis. The corresponding nomogram model was further built to predict the survival status of patients. Results Among patients, the 1-, 3-, and 5-year OS rates were 70.7%, 35.9% and 30.9%, respectively. The 1-, 3- and 5-year RFS rates of the 55 patients who underwent R0 resection were 76.1%, 50.8% and 34.4%, respectively. The multivariate analysis revealed that resection method, tumor size, status of pathological differentiation, pathological subtypes and recurrence pattern were independent risk factors for OS or RFS. Patients with distant recurrence (DR) pattern usually had multifocal tumors (90.5% vs. 74.7%, P < 0.05); they were prone to experience changes of pathological differentiation (69.9% vs. 33.3%, P < 0.05) and had a better prognosis than those with local recurrence (LR) pattern. R0 resection and combined organ resection favored the survival of patients with DR pattern in some cases. Conclusions Patients with DR pattern had better prognosis, and they may benefit more from aggressive combined resection than those with LR pattern. Classifying the recurrence patterns of RLS provides guidance for individualized clinical management of recurrent RLS. |
| first_indexed | 2024-03-11T11:04:33Z |
| format | Article |
| id | doaj.art-9f8da5affc9b4ed5a3540e140432ea8e |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-11T11:04:33Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9f8da5affc9b4ed5a3540e140432ea8e2023-11-12T12:20:15ZengBMCBMC Cancer1471-24072023-11-0123111510.1186/s12885-023-11586-8Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patternsHuan Deng0Jingwang Gao1Xingming Xu2Guibin Liu3Liqiang Song4Yisheng Pan5Bo Wei6Department of Gastrointestinal Surgery, Peking University First HospitalDepartment of General Surgery, the First Medical Center, Chinese People’s Liberation Army General HospitalDepartment of General Surgery, the First Medical Center, Chinese People’s Liberation Army General HospitalDepartment of General Surgery, the First Medical Center, Chinese People’s Liberation Army General HospitalDepartment of General Surgery, the First Medical Center, Chinese People’s Liberation Army General HospitalDepartment of Gastrointestinal Surgery, Peking University First HospitalDepartment of General Surgery, the First Medical Center, Chinese People’s Liberation Army General HospitalAbstract Background The clinical profiles of recurrent retroperitoneal liposarcoma (RLS) need to be explored. The recurrence patterns of RLS are controversial and ambiguous. Methods A total of 138 patients with recurrent RLS were finally recruited in the study. The analysis of overall survival (OS) and recurrence-free survival (RFS) was performed by Kaplan‒Meier analysis. To identify independent prognostic factors, all significant variables on univariate Cox regression analysis (P ≤ 0.05) were subjected to multivariate Cox regression analysis. The corresponding nomogram model was further built to predict the survival status of patients. Results Among patients, the 1-, 3-, and 5-year OS rates were 70.7%, 35.9% and 30.9%, respectively. The 1-, 3- and 5-year RFS rates of the 55 patients who underwent R0 resection were 76.1%, 50.8% and 34.4%, respectively. The multivariate analysis revealed that resection method, tumor size, status of pathological differentiation, pathological subtypes and recurrence pattern were independent risk factors for OS or RFS. Patients with distant recurrence (DR) pattern usually had multifocal tumors (90.5% vs. 74.7%, P < 0.05); they were prone to experience changes of pathological differentiation (69.9% vs. 33.3%, P < 0.05) and had a better prognosis than those with local recurrence (LR) pattern. R0 resection and combined organ resection favored the survival of patients with DR pattern in some cases. Conclusions Patients with DR pattern had better prognosis, and they may benefit more from aggressive combined resection than those with LR pattern. Classifying the recurrence patterns of RLS provides guidance for individualized clinical management of recurrent RLS.https://doi.org/10.1186/s12885-023-11586-8Retroperitoneal liposarcomaRecurrence patternPrognosisDistant recurrenceLocal recurrence |
| spellingShingle | Huan Deng Jingwang Gao Xingming Xu Guibin Liu Liqiang Song Yisheng Pan Bo Wei Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patterns BMC Cancer Retroperitoneal liposarcoma Recurrence pattern Prognosis Distant recurrence Local recurrence |
| title | Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patterns |
| title_full | Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patterns |
| title_fullStr | Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patterns |
| title_full_unstemmed | Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patterns |
| title_short | Predictors and outcomes of recurrent retroperitoneal liposarcoma: new insights into its recurrence patterns |
| title_sort | predictors and outcomes of recurrent retroperitoneal liposarcoma new insights into its recurrence patterns |
| topic | Retroperitoneal liposarcoma Recurrence pattern Prognosis Distant recurrence Local recurrence |
| url | https://doi.org/10.1186/s12885-023-11586-8 |
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