Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women
BackgroundDepression is a heterogenous disorder with both cognitive and somatic symptom dimensions that may differentially relate to systemic inflammation. Diet, which has the potential to modulate both inflammation levels and mood, is yet to be studied within the context of individual depression di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.822466/full |
| _version_ | 1811233806584119296 |
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| author | Danielle Belden Hazeltine Danielle Belden Hazeltine Ashley Rose Polokowski Ashley Rose Polokowski Ashley Rose Polokowski Laura Christine Reigada Laura Christine Reigada |
| author_facet | Danielle Belden Hazeltine Danielle Belden Hazeltine Ashley Rose Polokowski Ashley Rose Polokowski Ashley Rose Polokowski Laura Christine Reigada Laura Christine Reigada |
| author_sort | Danielle Belden Hazeltine |
| collection | DOAJ |
| description | BackgroundDepression is a heterogenous disorder with both cognitive and somatic symptom dimensions that may differentially relate to systemic inflammation. Diet, which has the potential to modulate both inflammation levels and mood, is yet to be studied within the context of individual depression dimensions. This study examined the associations between inflammatory cytokines and dietary patterns with depressive symptom dimension profiles among a sample of women recruited in a non-clinical setting.MethodsInflammatory cytokines (IL-6 and TNF-α), inflammatory diet (Diet Inflammatory Index; DII), and depressive symptoms (Beck Depression Inventory-II; BDI-II) were measured in 136 females (Mage = 22.01 ± 4.02, range 18–59 years). Multiple linear regressions were used to investigate the relationships between inflammatory cytokines and diet with self-reported cognitive, somatic, and total depressive symptoms, adjusting for demographic factors.ResultsFindings showed that increased somatic dimension scores were positively associated with IL-6 (ß = 0.273, p = 0.002) and TNF-α (ß = 0.215, p = 0.017), but not inflammatory diet (p = 0.300). Total BDI-II scores were only positively associated with IL-6 (ß = 0.221, p = 0.012), and cognitive dimension scores were not associated with any inflammation measures.ConclusionsThese findings contribute to existing evidence that inflammatory cytokines are associated with the somatic symptoms of depression. Inflammatory diet index was not associated with depression measures. |
| first_indexed | 2024-04-12T11:26:43Z |
| format | Article |
| id | doaj.art-9f8db2c3252247ac97ec69458634ae70 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T11:26:43Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-9f8db2c3252247ac97ec69458634ae702022-12-22T03:35:13ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-05-011310.3389/fpsyt.2022.822466822466Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of WomenDanielle Belden Hazeltine0Danielle Belden Hazeltine1Ashley Rose Polokowski2Ashley Rose Polokowski3Ashley Rose Polokowski4Laura Christine Reigada5Laura Christine Reigada6Department of Psychology, Brooklyn College, City University of New York, New York, NY, United StatesProgram in Psychology, The Graduate Center, City University of New York, New York, NY, United StatesDepartment of Psychology, Brooklyn College, City University of New York, New York, NY, United StatesProgram in Psychology, The Graduate Center, City University of New York, New York, NY, United StatesPsycho-Oncology, Monter Cancer Center, Northwell Health Cancer Institute, New York, NY, United StatesDepartment of Psychology, Brooklyn College, City University of New York, New York, NY, United StatesProgram in Psychology, The Graduate Center, City University of New York, New York, NY, United StatesBackgroundDepression is a heterogenous disorder with both cognitive and somatic symptom dimensions that may differentially relate to systemic inflammation. Diet, which has the potential to modulate both inflammation levels and mood, is yet to be studied within the context of individual depression dimensions. This study examined the associations between inflammatory cytokines and dietary patterns with depressive symptom dimension profiles among a sample of women recruited in a non-clinical setting.MethodsInflammatory cytokines (IL-6 and TNF-α), inflammatory diet (Diet Inflammatory Index; DII), and depressive symptoms (Beck Depression Inventory-II; BDI-II) were measured in 136 females (Mage = 22.01 ± 4.02, range 18–59 years). Multiple linear regressions were used to investigate the relationships between inflammatory cytokines and diet with self-reported cognitive, somatic, and total depressive symptoms, adjusting for demographic factors.ResultsFindings showed that increased somatic dimension scores were positively associated with IL-6 (ß = 0.273, p = 0.002) and TNF-α (ß = 0.215, p = 0.017), but not inflammatory diet (p = 0.300). Total BDI-II scores were only positively associated with IL-6 (ß = 0.221, p = 0.012), and cognitive dimension scores were not associated with any inflammation measures.ConclusionsThese findings contribute to existing evidence that inflammatory cytokines are associated with the somatic symptoms of depression. Inflammatory diet index was not associated with depression measures.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.822466/fulldepressioninflammationdietcytokinessomaticneurovegetative |
| spellingShingle | Danielle Belden Hazeltine Danielle Belden Hazeltine Ashley Rose Polokowski Ashley Rose Polokowski Ashley Rose Polokowski Laura Christine Reigada Laura Christine Reigada Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women Frontiers in Psychiatry depression inflammation diet cytokines somatic neurovegetative |
| title | Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women |
| title_full | Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women |
| title_fullStr | Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women |
| title_full_unstemmed | Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women |
| title_short | Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women |
| title_sort | inflammatory cytokines but not dietary patterns are related to somatic symptoms of depression in a sample of women |
| topic | depression inflammation diet cytokines somatic neurovegetative |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.822466/full |
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