Neural activation associated with outgroup helping in adolescent rats
Summary: Prosocial behavior, helping others in need in particular, occurs preferentially in response to the perceived distress of one’s own group members or ingroup. To investigate the development of ingroup bias, neural activity during a helping test was analyzed in adolescent and adult rats. Altho...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222006836 |
| _version_ | 1818236852765720576 |
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| author | Jocelyn M. Breton Jordan S. Eisner Vaidehi S. Gandhi Natalie Musick Aileen Zhang Kimberly L.P. Long Olga S. Perloff Kelsey Y. Hu Chau M. Pham Pooja Lalchandani Matthew K. Barraza Ben Kantor Daniela Kaufer Inbal Ben-Ami Bartal |
| author_facet | Jocelyn M. Breton Jordan S. Eisner Vaidehi S. Gandhi Natalie Musick Aileen Zhang Kimberly L.P. Long Olga S. Perloff Kelsey Y. Hu Chau M. Pham Pooja Lalchandani Matthew K. Barraza Ben Kantor Daniela Kaufer Inbal Ben-Ami Bartal |
| author_sort | Jocelyn M. Breton |
| collection | DOAJ |
| description | Summary: Prosocial behavior, helping others in need in particular, occurs preferentially in response to the perceived distress of one’s own group members or ingroup. To investigate the development of ingroup bias, neural activity during a helping test was analyzed in adolescent and adult rats. Although adults selectively released trapped ingroup members, adolescent rats helped both ingroup and outgroup members, suggesting that ingroup bias emerges in adulthood. Analysis of brain-wide neural activity, indexed by expression of the early-immediate gene c-Fos, revealed increased activity for ingroup members across a broad set of regions previously associated with empathy. Adolescents showed reduced hippocampal and insular activity and increased orbitofrontal cortex activity compared to adults. Non-helper adolescents demonstrated increased amygdala connectivity. These findings demonstrate that biases for group-dependent prosocial behavior develop with age in rats and suggest that specific brain regions contribute to prosocial selectivity, pointing to possible targets for the functional modulation of ingroup bias. |
| first_indexed | 2024-12-12T12:16:27Z |
| format | Article |
| id | doaj.art-9f8dfb623a2649288d2d0f86e2fb1466 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-12T12:16:27Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-9f8dfb623a2649288d2d0f86e2fb14662022-12-22T00:24:46ZengElsevieriScience2589-00422022-06-01256104412Neural activation associated with outgroup helping in adolescent ratsJocelyn M. Breton0Jordan S. Eisner1Vaidehi S. Gandhi2Natalie Musick3Aileen Zhang4Kimberly L.P. Long5Olga S. Perloff6Kelsey Y. Hu7Chau M. Pham8Pooja Lalchandani9Matthew K. Barraza10Ben Kantor11Daniela Kaufer12Inbal Ben-Ami Bartal13Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USAMolecular and Cellular Biology, University of California Berkeley, Berkeley, CA 94720, USAMolecular and Cellular Biology, University of California Berkeley, Berkeley, CA 94720, USAIntegrative Biology, University of California Berkeley, Berkeley, CA 94720, USAIntegrative Biology, University of California Berkeley, Berkeley, CA 94720, USAHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USAIntegrative Biology, University of California Berkeley, Berkeley, CA 94720, USAMolecular and Cellular Biology, University of California Berkeley, Berkeley, CA 94720, USAIntegrative Biology, University of California Berkeley, Berkeley, CA 94720, USAIntegrative Biology, University of California Berkeley, Berkeley, CA 94720, USAMolecular and Cellular Biology, University of California Berkeley, Berkeley, CA 94720, USASchool of Psychological Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv-Yafo, Israel, 6997801Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA; Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA; Canadian Institute for Advanced Research, Toronto, ON M5G1M1, CanadaSchool of Psychological Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv-Yafo, Israel, 6997801; Corresponding authorSummary: Prosocial behavior, helping others in need in particular, occurs preferentially in response to the perceived distress of one’s own group members or ingroup. To investigate the development of ingroup bias, neural activity during a helping test was analyzed in adolescent and adult rats. Although adults selectively released trapped ingroup members, adolescent rats helped both ingroup and outgroup members, suggesting that ingroup bias emerges in adulthood. Analysis of brain-wide neural activity, indexed by expression of the early-immediate gene c-Fos, revealed increased activity for ingroup members across a broad set of regions previously associated with empathy. Adolescents showed reduced hippocampal and insular activity and increased orbitofrontal cortex activity compared to adults. Non-helper adolescents demonstrated increased amygdala connectivity. These findings demonstrate that biases for group-dependent prosocial behavior develop with age in rats and suggest that specific brain regions contribute to prosocial selectivity, pointing to possible targets for the functional modulation of ingroup bias.http://www.sciencedirect.com/science/article/pii/S2589004222006836Behavioral neuroscienceCellular neuroscience |
| spellingShingle | Jocelyn M. Breton Jordan S. Eisner Vaidehi S. Gandhi Natalie Musick Aileen Zhang Kimberly L.P. Long Olga S. Perloff Kelsey Y. Hu Chau M. Pham Pooja Lalchandani Matthew K. Barraza Ben Kantor Daniela Kaufer Inbal Ben-Ami Bartal Neural activation associated with outgroup helping in adolescent rats iScience Behavioral neuroscience Cellular neuroscience |
| title | Neural activation associated with outgroup helping in adolescent rats |
| title_full | Neural activation associated with outgroup helping in adolescent rats |
| title_fullStr | Neural activation associated with outgroup helping in adolescent rats |
| title_full_unstemmed | Neural activation associated with outgroup helping in adolescent rats |
| title_short | Neural activation associated with outgroup helping in adolescent rats |
| title_sort | neural activation associated with outgroup helping in adolescent rats |
| topic | Behavioral neuroscience Cellular neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222006836 |
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