New insights into Regulatory T cells：exosome and non-coding RNA mediated regulation of homeostasis, and resident regulatory T cells
Regulatory T (Treg) cells are a population of cells that are heterogeneous in origin and in functional activity. Treg cells constitute an essential counterbalance to adaptive immune responses. As key regulators of self-tolerance, Treg cells have been implicated in a number of pathologic processes an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00574/full |
| Summary: | Regulatory T (Treg) cells are a population of cells that are heterogeneous in origin and in functional activity. Treg cells constitute an essential counterbalance to adaptive immune responses. As key regulators of self-tolerance, Treg cells have been implicated in a number of pathologic processes and considered as therapeutic targets. Here, we summarize recent research regarding Treg cell origins and their functional classification, highlight the role of exosomes and non-coding RNA in modulating Treg cell homeostasis, and discuss the current understanding of resident Treg cells. |
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| ISSN: | 1664-3224 |