Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia
Abstract Introduction It remains unclear whether COVID-19 which is an infectious disease caused by the SARS-CoV-2 virus is associated with the deterioration of cognitive function among patients with schizophrenia. This study aimed to evaluate changes in cognitive function before and after COVID-19 a...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Annals of General Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12991-023-00435-4 |
| _version_ | 1797863960998838272 |
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| author | Chadia Haddad Angela Chamoun Hala Sacre Souheil Hallit Pascale Salameh Benjamin Calvet |
| author_facet | Chadia Haddad Angela Chamoun Hala Sacre Souheil Hallit Pascale Salameh Benjamin Calvet |
| author_sort | Chadia Haddad |
| collection | DOAJ |
| description | Abstract Introduction It remains unclear whether COVID-19 which is an infectious disease caused by the SARS-CoV-2 virus is associated with the deterioration of cognitive function among patients with schizophrenia. This study aimed to evaluate changes in cognitive function before and after COVID-19 and associated factors among patients with schizophrenia at the Psychiatric Hospital of the Cross (HPC). Methods A prospective cohort study was conducted among 95 patients with schizophrenia followed from mid-2019 until June 2021 at the Psychiatric Hospital of the Cross (HPC). This cohort was divided into a group diagnosed with COVID-19 (n = 71) and another not diagnosed with COVID-19 (n = 24). The questionnaire included the Brief Assessment of Cognition in Schizophrenia (BACS), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), and Activities of Daily Living (ADL). Results The repeated-measures ANOVA showed no significant effect of time and the interaction between time and being diagnosed or not with COVID-19 on cognition. However, being diagnosed or not with COVID-19 had a significant effect on global cognitive function (p = 0.046), verbal memory (p = 0.046), and working memory (p = 0.047). The interaction between being diagnosed with COVID-19 and cognitive impairment at baseline was significantly associated with a higher cognitive deficit (Beta = 0.81; p = 0.005). Clinical symptoms, autonomy, and depression were not associated with the cognition (p > 0.05 for all). Conclusion COVID-19 disease affected global cognition and memory: patients diagnosed with COVID-19 had more deficits in these domains than those without COVID-19. Further studies are necessary to clarify the variation of cognitive function among schizophrenic patients with COVID-19. |
| first_indexed | 2024-04-09T22:44:00Z |
| format | Article |
| id | doaj.art-9f92cde73429424084109a0cdb1c3dba |
| institution | Directory Open Access Journal |
| issn | 1744-859X |
| language | English |
| last_indexed | 2024-04-09T22:44:00Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of General Psychiatry |
| spelling | doaj.art-9f92cde73429424084109a0cdb1c3dba2023-03-22T11:59:11ZengBMCAnnals of General Psychiatry1744-859X2023-03-0122111210.1186/s12991-023-00435-4Cognitive function in recovered COVID-19 Lebanese patients with schizophreniaChadia Haddad0Angela Chamoun1Hala Sacre2Souheil Hallit3Pascale Salameh4Benjamin Calvet5Research Department, Psychiatric Hospital of the CrossFaculty of Sciences, Lebanese UniversityInstitut National de Santé Publique, d’Épidémiologie Clinique et de Toxicologie-Liban (INSPECT-LB)Research Department, Psychiatric Hospital of the CrossInstitut National de Santé Publique, d’Épidémiologie Clinique et de Toxicologie-Liban (INSPECT-LB)Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealthAbstract Introduction It remains unclear whether COVID-19 which is an infectious disease caused by the SARS-CoV-2 virus is associated with the deterioration of cognitive function among patients with schizophrenia. This study aimed to evaluate changes in cognitive function before and after COVID-19 and associated factors among patients with schizophrenia at the Psychiatric Hospital of the Cross (HPC). Methods A prospective cohort study was conducted among 95 patients with schizophrenia followed from mid-2019 until June 2021 at the Psychiatric Hospital of the Cross (HPC). This cohort was divided into a group diagnosed with COVID-19 (n = 71) and another not diagnosed with COVID-19 (n = 24). The questionnaire included the Brief Assessment of Cognition in Schizophrenia (BACS), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), and Activities of Daily Living (ADL). Results The repeated-measures ANOVA showed no significant effect of time and the interaction between time and being diagnosed or not with COVID-19 on cognition. However, being diagnosed or not with COVID-19 had a significant effect on global cognitive function (p = 0.046), verbal memory (p = 0.046), and working memory (p = 0.047). The interaction between being diagnosed with COVID-19 and cognitive impairment at baseline was significantly associated with a higher cognitive deficit (Beta = 0.81; p = 0.005). Clinical symptoms, autonomy, and depression were not associated with the cognition (p > 0.05 for all). Conclusion COVID-19 disease affected global cognition and memory: patients diagnosed with COVID-19 had more deficits in these domains than those without COVID-19. Further studies are necessary to clarify the variation of cognitive function among schizophrenic patients with COVID-19.https://doi.org/10.1186/s12991-023-00435-4CognitionCOVID-19SchizophreniaInfectionDisease |
| spellingShingle | Chadia Haddad Angela Chamoun Hala Sacre Souheil Hallit Pascale Salameh Benjamin Calvet Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia Annals of General Psychiatry Cognition COVID-19 Schizophrenia Infection Disease |
| title | Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia |
| title_full | Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia |
| title_fullStr | Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia |
| title_full_unstemmed | Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia |
| title_short | Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia |
| title_sort | cognitive function in recovered covid 19 lebanese patients with schizophrenia |
| topic | Cognition COVID-19 Schizophrenia Infection Disease |
| url | https://doi.org/10.1186/s12991-023-00435-4 |
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